Cancer Guidelines Database

Access quality cancer guidelines from a single Canadian source

We've listed 568 guidelines under your selection of "Continuum of care". The most recent guidelines are first.

Early Detection for Colorectal Cancer: ASCO Resource-Stratified Guideline

Year: 2019
AGREE II score: Available
Developer organization: American Society of Clinical Oncology
This clinical practice guideline focuses on the early detection of colorectal cancer and the management of polyps found during colorectal cancer screening among those at average risk, as well as the workup and diagnosis of colorectal cancer. The guideline discusses the optimal strategies for population-level early detection of colorectal cancer in high-incidence and resource-constrained settings, the optimal reflex testing strategy for people with positive screening results, the optimal strategy for people with premalignant polyps or other abnormal screening results, and the optimal methods for diagnosing patients who have signs and symptoms of early colorectal cancer. Recommendations are resource-stratified and are tailored to basic, limited, enhanced and maximal resource settings.

Neuroendocrine and Adrenal Tumours, Version 4.2018

Year: 2019
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with neuroendocrine or adrenal tumours. The guideline discusses the diagnosis, staging, treatment, and follow-up of patients with sporadic neuroendocrine tumours, originating from organs such as the lungs, thymus, and gastrointestinal (GI) tract. The guideline also examines the role of the genetic syndrome, multiple endocrine neoplasia (MEN), in developing parathyroid, pituitary, and pancreatic tumours.

Treatment of Multiple Myeloma: ASCO and CCO Joint Clinical Practice Guideline

Year: 2019
AGREE II score: Available
Developer organization: American Society of Clinical Oncology
This is a clinical practice guideline for patients with multiple myeloma. The guideline provides recommendations for the treatment of both newly diagnosed and relapsed patients. Outcomes of interest include overall survival, progression-free survival, response rate, and quality of life.

Evidenced-Based Guideline for Colorectal Cancer

Year: 2019
AGREE II score: Available
Developer organization: German Guideline Program in Oncology
This is a clinical practice guideline for physicians who work on the prevention and treatment of colorectal cancer in the ambulatory and inpatient sector. The guideline provides recommendations for prevention, screening in asymptomatic populations as well as high risk populations, the role of endoscopy in the diagnosis of polyps and colorectal cancer, pre-operative diagnostics and surgery, adjuvant and neoadjuvant therapy, management of patients with metastases, palliative care and follow-up care.

Referral of Suspected Lung Cancer by Family Physicians and Other Primary Care Providers

Year: 2019
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for patients presenting to primary care services with signs and/or symptoms of lung cancer. The guideline examines the referral process for this patient population. Topics of interest include factors that have been shown to increase the risk of lung cancer, symptoms that should be present in a person before referral, indications for chest computed tomography (CT) scan, and follow-up to diagnostic investigations.

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 5.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with chronic lymphocytic leukemia, or small lymphocytic lymphoma. The guideline examines the diagnosis, staging, treatment, and follow-up of these patients. Prognosis and treatment algorithms are presented based on patient characteristics such as age, and genetic profile.

Bladder Cancer, Version 4.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with bladder cancer. Non-muscle-invasive urothelial bladder cancer, muscle-invasive urothelial bladder cancer, metastatic (Stage IVB) urothelial bladder cancer, non-urothelial carcinomas of the bladder, upper tract urothelial carcinoma (UTUC), urothelial carcinomas of the prostate, and primary carcinomas of the urethra are all specifically discussed. The guideline provides algorithms for diagnosis, staging, treatment, and follow-up.

Primary Cutaneous Lymphomas, Version 2.2019

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
A clinical practice guideline on the diagnosis, workup, and treatment of patients who have been diagnosed with or are suspected of having primary cutaneous B-cell lymphomas (PCBCLs). The guideline focuses on the three main types of PCBCLs: primary cutaneous marginal zone lymphoma (PCMZL), primary cutaneous follicle-center lymphoma (PCFCL), and primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL, leg type). Recommendations for treatment are provided based on lymphoma type and whether treatment is for initial, relapsed, or refractory disease.

Hepatobiliary Cancers, Version 1.2019

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for hepatobiliary cancers. The guideline examines the clinical management of patients with hepatocellular carcinoma (HCC), gallbladder cancer, as well as intrahepatic and extrahepatic cholangiocarcinoma. Risk factors, diagnosis, staging and prognosis, and treatment are discussed for the different conditions.

Cervical Cancer, Version 3.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for women with cervical cancer. The guideline examines the initial diagnosis and workup, staging, primary and adjuvant treatment, surveillance, and therapy following relapse for these patients. Treatment for metastatic disease is also discussed, as are the topics of incidental cervical cancer and the occurrence of cervical cancer in pregnant women.

Evaluating Susceptibility to Pancreatic Cancer: ASCO Provisional Clinical Opinion

Year: 2018
AGREE II score: Available
Developer organization: American Society of Clinical Oncology
This provisional clinical opinion addresses identification and management of patients and family members with possible predisposition to pancreatic adenocarcinoma. Recommendations are provided around the appropriate methods for determining patients' susceptibility to developing pancreatic cancer, which individuals should undergo genetic testing, and the surveillance strategies that should be used for individuals with predispositions to pancreatic ductal adenocarcinoma to screen for pancreatic and other cancers.

Pancreatic Adenocarcinoma, Version 1.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with pancreatic adenocarcinoma. The guideline examines risk factors and genetic predisposition, pancreatic cancer screening, diagnosis and staging, systemic therapy approaches, radiation and chemoradiation approaches, surveillance of patients with resected disease, as well as palliative and supportive care. Management of metastatic disease, locally advanced disease, resectable and borderline resectable disease, and recurrent disease after resection is also considered.

Myelodysplastic Syndromes, Version 2.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with myelodysplastic syndromes (MDS). The guideline discusses diagnostic classification, evaluation, prognostic stratification, therapeutic options, and recommended treatment approaches for MDS. There is a particular focus on supportive care, and the guideline also provides recommendations for the management of thrombocytopenia and iron overload, the treatment of related anemia, the use of low-intensity therapy (i.e. hypomethylating agents or biologic response modifiers and immunosuppressive therapy), and high-intensity therapy.

Multiple Myeloma, Version 4.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with multiple myeloma. The guideline examines the primary therapy and surveillance/follow-up tests for both solitary plasmacytoma and smoldering (asymptomatic) myeloma, and the primary therapy and monitoring for active (symptomatic) myeloma. Stem cell transplants (SCT), including autologous SCT, tandem SCT, and allogeneic SCT, as well as follow-up after stem cell transplants, are also discussed. In addition, the guideline considers diagnostic tests, response criteria, maintenance therapy, treatment of progressive or relapsed myeloma, and supportive care treatment.

Hodgkin Lymphoma Version, 3.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for adults with classical Hodgkin lymphoma (CHL) and nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). The guideline discusses the clinical management of patients with CHL and NLPHL, focusing on patients who do not have serious intercurrent disease. Treatment options examined include chemotherapy, high dose therapy and autologous stem cell rescue (HDT/ASCR), and involved site radiation therapy (ISRT).

Hairy Cell Leukemia, Version 2.2019

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with hairy cell leukemia. The guideline provides recommendations regarding diagnosis, initial treatment, response assessment and additional therapy, second-line therapy for relapsed/refractory or progressive disease, and supportive care. The impact of infections, such as hepatitis B (HBV) is also discussed.

Human Papillomavirus Testing in Head and Neck Carcinomas: ASCO Clinical Practice Guideline Endorsement of the College of American Pathologists Guideline

Year: 2018
AGREE II score: Available
Developer organization: American Society of Clinical Oncology
This clinical practice guideline is an endorsement of the College of American Pathologists' 2018 guideline titled Human Papillomavirus Testing in Head and Neck Carcinomas. The guideline examines the optimal way to test, apply, interpret, and report HPV and surrogate marker tests in head and neck carcinomas. Specific types of cancer discussed include oropharyngeal squamous cell carcinoma (OPSCC), oropharyngeal non-squamous cell carcinoma, and cervical nodal metastatic carcinomas of unknown primary site.

Endoscopic Eradication Therapy for Patients With Barrett’s Esophagus–Associated Dysplasia and Intramucosal Cancer

Year: 2018
AGREE II score: Available
Developer organization: American Society for Gastrointestinal Endoscopy
This is a clinical practice guideline for patients with Barrett's esophagus (BE), which is the only identifiable premalignant condition for esophageal adenocarcinoma (EAC). The guideline examines endoscopic eradication therapy (EET) and its role in the management of BE-related neoplasia. Outcomes of interest include progression to cancer, cancer-specific and all-cause mortality, adverse events, and recurrence rates.

Brain Tumours (Primary) and Brain Metastases in Adults

Year: 2018
AGREE II score: Available
Developer organization: National Institute for Health and Care Excellence
This is a clinical practice guideline for patients aged 16 or older who have primary brain tumours or brain metastases. Specifically, the guideline examines the diagnoses and management of radiologically identified glioma, meningioma, and brain metastases. Follow-up care after treatment and supportive care are also discussed, and additional recommendations are provided on the referral of adults with primary brain tumours or brain metastases for neurological rehabilitation assessment.

Guidelines for the Diagnosis and Management of Primary Central Nervous System Diffuse Large B-Cell Lymphoma

Year: 2018
AGREE II score: Available
Developer organization: British Society for Haematology
This is a clinical practice guideline for patients who have or are suspected of having primary central nervous system diffuse large B-cell lymphoma (PCNSL) located in the brain, spinal cord, cranial nerves, eyes or meninges. Specific topics discussed include diagnosis and imaging, treatment of primary CNS lymphoma, remission induction, consolidation treatment, follow-up, relapsed and refractory PCNSL, and neuropsychological assessments.

Gallium-68 PET Imaging in Neuroendocrine Tumours

Year: 2018
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adult and pediatric patients with suspected or diagnosed well-differentiated neuroendocrine tumours (NETs). The guideline discusses the clinical utility of Gallium-68 positron emission tomography (PET) compared with PET / computed tomography imaging for the initial diagnosis, staging, re-staging, response evaluation, and routine surveillance of patients with NETs.

Adolescent and Young Adult (AYA) Oncology, Version 1.2019

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for adolescents and young adults with cancer. The guideline discusses risk factors, screening, diagnosis, management, follow-up, supportive care, and palliative care for patients between 15 and 39 years of age. Unique issues discussed include adherence to treatment, the impact of cancer and its treatment on fertility, management of cancer during pregnancy, relationship management, and socioeconomic issues.

Non-Small Cell Lung Cancer, Version 2.2019

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with non-small cell lung cancer. The guideline examines the risk factors, classification factors, diagnostic evaluation, pathologic evaluation, staging, predictive and prognostic biomarkers, treatment, and surveillance of lung cancer. Treatment approaches considered include surgery, radiation therapy, and combined modality therapy. The discussion on initial therapy is stratified by disease stage.

Colon Cancer, Version 4.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for the management of colon cancer. Recommendations are made for diagnosis, pathologic staging, surgical management, perioperative treatment, surveillance, and management of recurrence. Principles for the management of metastatic disease are also provided.

AIDS-Related Kaposi Sarcoma, Version 2.2019

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with AIDS-related Kaposi sarcoma. The guideline examines diagnosis, staging, treatment, and follow-up, while also providing recommendations on HIV screening and HIV therapy during cancer treatment. Antiretroviral therapy (ART), topical therapies, intralesional chemotherapy, local incisions, radiation therapy, and systemic therapy are all discussed as treatment options.

Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology / College of American Pathologists Clinical Practice Guideline Focused Update

Year: 2018
AGREE II score: Available
Developer organization: American Society of Clinical Oncology
This clinical practice guideline is a focused update of the American Society of Clinical Oncology / College of American Pathologists 2013 guideline on human epidermal growth factor receptor 2 (HER2) testing in breast cancer. Recommendations are provided around what the most appropriate definition is for immunohistochemistry (IHC) 2+, whether HER2 testing should be repeated on surgical specimens if initial core biopsy results are negative, and which invasive cancers should be considered in situ hybridization (ISH) positive. In addition, appropriate diagnostic workup is discussed for invasive cancers based on the HER2 signals present.

The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for Anal Squamous Cell Cancers (Revised 2018)

Year: 2018
AGREE II score: Unavailable
Developer organization: American Society of Colon and Rectal Surgeons
This is a clinical practice guideline for patients with squamous cell cancers (SCC) of the anal canal and perianal region. The guideline specifically examines management options for premalignant and malignant squamous neoplasms of the anus and perianal region. Recommendations are provided regarding screening options, primary treatment, and surveillance for SCC and perianal squamous cell cancers.

British Thoracic Society Guideline for the Investigation and Management of Malignant Pleural Mesothelioma

Year: 2018
AGREE II score: Available
Developer organization: British Thoracic Society
This is a clinical practice guideline for patients with malignant pleural mesothelioma (MPM). The guideline provides recommendations on the investigation of suspected MPM, and the subsequent care and management of individuals with proven MPM. Topics of interest include the preferred investigation pathway of suspected cases of MPM, biomarkers, and the role of different treatments including chemotherapy.

Early and Locally Advanced Breast Cancer: Diagnosis and Management

Year: 2018
AGREE II score: Available
Developer organization: National Institute for Health and Care Excellence
This is a clinical practice guideline for the diagnosis and management of early and locally advanced breast cancer. The guideline provides recommendations on referral, diagnosis, preoperative assessment, genetic testing, surgical procedures, breast reconstruction, psychological support, and adjuvant therapies such as endocrine therapy and bisphosphonate therapy.

Chronic Lymphocytic Leukemia

Year: 2018
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients with chronic lymphocytic leukemia. The guideline examines the diagnostic and staging criteria, treatment strategies, and follow-up and supportive care practices for these patients. First and second line treatment options are discussed for newly diagnosed, relapsed, and refractory disease.

Acute Myeloid Leukemia

Year: 2018
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients with acute myeloid leukemia (AML). The guideline examines the diagnostic criteria and prognostic markers of acute myeloid leukemias. Different management options for acute myeloid leukemia are discussed, including chemotherapy, hematopoietic stem cell transplantation, and palliation.

Thyroid Carcinoma, Version 1.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with diagnosed or suspected thyroid carcinoma. The guideline discusses the initial workup, diagnosis, staging, treatment, and follow up of patients with differentiated, papillary, follicular, medullary, and anaplastic thyroid carcinoma, as well as Hürthle cell carcinoma. Surgery, radiation therapy, and systemic therapy are discussed as treatment options.

Small Cell Lung Cancer, Version 2.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with small cell lung cancer. The guideline examines the diagnosis, staging, prognostic factors, treatment, and surveillance of these patients. Treatment options discussed include systemic therapy, radiotherapy, and surgical resection. Systemic therapy is further examined in elderly patients, and as a second-line (and beyond) treatment. Radiotherapy treatments considered include thoracic radiotherapy, prophylactic cranial irradiation, and palliative radiotherapy.

Penile Cancer, Version 2.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for the management of squamous cell carcinoma (SCC) of the penis. The guideline examines the diagnosis, treatment, and follow-up for patients with this form of cancer. Outcomes of interest include optimizing therapeutic efficacy and minimizing treatment-related morbidity.

Ovarian Cancer Including Fallopian Tube Cancer and Primary Peritoneal Cancer, Version 2.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for adult patients with ovarian cancer, fallopian tube cancer, or primary peritoneal cancer. Recommendations are provided for screening, staging, diagnosis, treatment, and follow-up. Treatment options discussed include debulking surgery, chemotherapy, and radiation therapy. Management of drug reactions is also discussed.

T-Cell Lymphomas, Version 4.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with T-cell lymphoma. The guideline examines the diagnostic workup, staging, treatment, follow-up, and supportive care for the most common subtypes of T-cell lymphoma. These subtypes include peripheral T-cell lymphomas (PTCLs), breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), mycosis fungoides (MF) and Sézary syndrome (SS), primary cutaneous CD30+ T-cell lymphoproliferative disorders, T-cell large granular lymphocytic leukemia (TGLL), adult T-cell leukemia/lymphoma (ATLL), T-cell prolymphocytic leukemia (TPLL), and extranodal NK/T-cell lymphomas (ENKL), nasal type.

B-Cell Lymphomas, Version 4.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
A clinical practice guideline on the diagnosis, workup, treatment and surveillance of B-cell lymphoma (BCL) in pediatric and adult patients. The guideline focuses on the most common B-cell lymphomas: follicular lymphoma (FL), marginal zone lymphomas (MZL), nodal MZL, splenic MZL, gastric MALT lymphoma, mantle cell lymphoma (MCL), diffuse large B-cell lymphoma (DLBCL), Burkitt lymphoma (BL), AIDS-related B-cell lymphoma, post-transplant lymphoproliferative disorders, and Castleman's disease. Additional consideration is paid to the classification systems used in NHL, the role of PET scans in assessment and staging, principles of radiation therapy, and supportive care considerations.

Colon Cancer, Version 2.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for the management of colon cancer. Recommendations are made for diagnosis, pathologic staging, surgical management, perioperative treatment, surveillance, and management of recurrence. Principles for the management of metastatic disease are also provided.

Acute Lymphoblastic Leukemia, Version 1.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for adolescent, young adult (AYA), and adult patients with acute lymphoblastic leukemia (ALL). The guideline reviews the classification of ALL subtypes based on immunophenotype and cytogenetic/molecular markers, and provides recommendations on risk assessment and stratification for risk-adapted therapy, as well as treatment strategies for Philadelphia chromosome (Ph)-positive and Ph-negative ALL. The guideline also provides recommendations for supportive care.

Thyroid Carcinoma, Version 3.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with diagnosed or suspected thyroid carcinoma. The guideline discusses the initial workup, diagnosis, staging, treatment, and follow up of patients with differentiated, papillary, follicular, medullary, and anaplastic thyroid carcinoma, as well as Hurthle cell carcinoma. Surgery, radiation therapy, and systemic therapy are discussed as treatment options.

Soft Tissue Sarcoma, Version 1.2019

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for the management of soft tissue sarcoma (STS) in adult patients. The guideline pertains to the following five subtypes of STS: (1) STS of extremity, superficial/trunk, or head and neck, (2) retroperitoneal or intra-abdominal STS, (3) gastrointestinal stromal tumours (GISTs), (4) desmoid tumours, and (5) rhabdomyosarcoma (RMS). The guideline provides recommendations for diagnosis, staging, treatment, palliative care, and surveillance. Surgery, chemotherapy, and radiotherapy are all examined as treatment options.

Penile Cancer, Version 1.2019

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for the management of squamous cell carcinoma (SCC) of the penis. The guideline examines the diagnosis, treatment, and follow-up for patients with this form of cancer. Outcomes of interest include optimizing therapeutic efficacy and minimizing treatment-related morbidity.

Occult Primary (Cancer of Unknown Primary [CUP]), Version 1.2019

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with epithelial occult primary cancer. The guideline provides recommendations for the evaluation, workup, management, and follow-up of two pathologic diagnoses in patients with epithelial occult primary cancer: adenocarcinoma, or carcinoma not otherwise specified (NOS), and squamous cell carcinoma (SCC). Management options considered include, chemotherapy, radiation therapy, locoregional therapeutic options, and specialized approaches, as well as supportive care and management of psychosocial distress.

Multiple Myeloma, Version 2.2019

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with multiple myeloma. The guideline examines the primary therapy and surveillance/follow-up tests for both solitary plasmacytoma and smoldering (asymptomatic) myeloma, and the primary therapy and monitoring for active (symptomatic) myeloma. Stem cell transplants (SCT), including autologous SCT, tandem SCT, and allogeneic SCT, as well as follow-up after stem cell transplants, are also discussed. In addition, the guideline considers diagnostic tests, response criteria, maintenance therapy, treatment of progressive or relapsed myeloma, and supportive care treatment.

Kidney Cancer, Version 2.2019

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with renal cell carcinoma (RCC). The guideline specifically examines the initial evaluation, staging, diagnosis, clinical management options, and follow-up of patients with clear cell carcinoma and non-clear cell carcinoma. Pharmacologic agents discussed include pazopanib, sunitinib, and nivolumab.

Acute Myeloid Leukemia, Version 3.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with acute myeloid leukemia (AML), including those with acute promyelocytic leukemia (APL). The guideline examines the initial evaluation of AML, risk stratification based on cytogenetics and molecular markers, management options, as well as supportive care. Management strategies are separated based on whether patients are above or below sixty years of age.

Treatment of Malignant Pleural Mesothelioma: American Society of Clinical Oncology Clinical Practice Guideline

Year: 2018
AGREE II score: Available
Developer organization: American Society of Clinical Oncology
This is a clinical practice guideline for patients who have been diagnosed with or are suspected of having malignant pleural mesothelioma. Recommendations are provided on diagnosis, staging, chemotherapy, surgical cytoreduction, radiation therapy, and multimodal therapy. Outcomes of interest include overall survival, progression-free survival, response rate, toxicity, quality of life (QoL), surgical complications, and diagnostic accuracy.

Human Papillomavirus Testing in Head and Neck Carcinomas

Year: 2018
AGREE II score: Available
Developer organization: College of American Pathologists
This is a clinical practice guideline on the testing for human papillomavirus (HPV) in patients with head and neck carcinomas. The guideline provides recommendations on the types of head and neck cancer that warrant HPV testing, testing methodologies, and how to report test results. Testing methodologies discussed include immunohistochemistry p16, polymerase chain reaction, and in situ hybridization. Outcomes of interest include negative predictive value and positive predictive value.

Lymphoma

Year: 2018
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients who have been diagnosed with or are suspected of having lymphoma. The guideline discusses Hodgkin lymphoma, as well as the most common non-Hodgkin lymphomas (T-cell and B-cell). Recommendations are provided on diagnosis, staging, treatment, management, and follow up care.

Prostate Cancer Early Detection, Version 2.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline developed for adult men who have elected to participate in an early prostate cancer detection program. The guideline provides a set of sequential recommendations detailing screening and evaluation strategies for maximizing the detection of prostate cancer that is effectively treatable and that, if left undetected, represents a risk to the patient. Several techniques designed to improve the identification of significant cancer, while avoiding the detection of indolent disease, are highlighted, including imaging, biomarker testing, and biopsy.

Prostate Cancer, Version 2.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with prostate cancer. The guideline examines various treatment options including active surveillance, radical prostatectomy, radiation therapy, other local therapies, androgen deprivation therapy, chemotherapy, and immunotherapy. It also discusses risk stratification, imaging, and estimates of life expectancy. Recommendations are provided for the initial diagnosis, clinical assessment, and staging evaluation, as well as for treatment, which are based on both the level of risk, and specific disease present.

Hepatobiliary Cancers, Version 2.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for hepatobiliary cancers. The guideline examines the clinical management of patients with hepatocellular carcinoma (HCC), gallbladder cancer, as well as intrahepatic and extrahepatic cholangiocarcinoma. Risk factors, diagnosis, staging and prognosis, and treatment are discussed for the different conditions.

Small Cell Lung Cancer, Version 1.2019

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with small cell lung cancer. The guideline examines the diagnosis, staging, prognostic factors, treatment, and surveillance of these patients. Treatment options discussed include systemic therapy, radiotherapy, and surgical resection. Systemic therapy is further examined in elderly patients, and as a second-line (and beyond) treatment. Radiotherapy treatments considered include thoracic radiotherapy, prophylactic cranial irradiation, and palliative radiotherapy.

Initial Diagnostic Work-Up of Acute Leukemia: ASCO Clinical Practice Guideline Endorsement of the College of American Pathologists and American Society of Hematology Guideline

Year: 2018
AGREE II score: Available
Developer organization: American Society of Clinical Oncology
This clinical practice guideline is an endorsement of the 2016 guideline titled Initial Diagnostic Work-up of Acute Leukemia: Guideline from the College of American Pathologists and the American Society of Hematology. The guideline examines the initial diagnostic work-up of acute leukemia (AL). Topics of interest include providing relevant clinical data or ensuring that they are readily accessible by the pathologist, providing relevant physical examination and imaging findings, and obtaining a fresh bone marrow (BM) aspirate for all patients suspected of AL.

A Guideline for the Diagnosis and Management of Polycythemia Vera

Year: 2018
AGREE II score: Available
Developer organization: British Society for Haematology
This is a clinical practice guideline for patients with polycythemia vera (PV). The guideline provides recommendations on diagnosis, risk stratification and management of PV. Specific topics discussed include the initial assessment, stage 1 investigations, considerations based on erythropoietin (EPO) levels, gene sequencing for congenital erythrocytosis, and cytoreductive therapy.

Breast Cancer Screening and Diagnosis, Version 3.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for women who have been diagnosed with or are at risk of developing breast cancer. The guideline examines the different methods of diagnosis and screening for breast cancer that will facilitate clinical decision-making. The guideline provides a consistent framework for screening and evaluating a spectrum of clinical breast lesions and takes into consideration different imaging modalities and screening recommendations for women at different levels of risk.

Vulvar Cancer (Squamous Cell Carcinoma), Version 2.2019

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for women with vulvar cancer, and particularly those with squamous cell carcinoma (SCC) of the vulva. The guideline examines diagnosis and workup, as well as primary treatment, adjuvant radiotherapy and chemotherapy, and surveillance of these patients. Treatment options are discussed for early-stage disease, locally advanced disease, and metastases beyond the pelvis.

Systemic Mastocytosis, Version 2.2019

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with systemic mastocytosis (SM). The guideline provides recommendations on the diagnostic criteria for variants of SM, as well as for treatment and follow-up. Specific variants discussed include indolent SM, smoldering SM, aggressive SM, and SM with an associated hematological neoplasm.

Myeloproliferative Neoplasms, Version 2.2019

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with myeloproliferative neoplasms. The guideline specifically examines the diagnosis, risk-stratification, treatment, and supportive care for patients with polycythemia vera (PV), essential thrombocythemia (ET) and myelofibrosis (MF). Risk-stratified treatment algorithms are provided for each disorder.

Myelodysplastic Syndromes, Version 2.2019

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with myelodysplastic syndromes (MDS). The guideline discusses diagnostic classification, evaluation, prognostic stratification, therapeutic options, and recommended treatment approaches for MDS. There is a particular focus on supportive care, and the guideline also provides recommendations for the management of thrombocytopenia and iron overload, the treatment of related anemia, the use of low-intensity therapy (i.e. hypomethylating agents or biologic response modifiers and immunosuppressive therapy), and high-intensity therapy.

Waldenström Macroglobulinemia/Lymphoplasmacytic Lymphoma, Version 2.2019

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with Waldenström's macroglobulinemia or lymphoplasmacytic lymphoma. The guideline examines the diagnosis, workup, primary treatment regimens, assessment of response to primary treatment, and follow-up after primary treatment. Regimens not toxic to stem cells and regimens with potential or unknown toxicity to stem cells are considered. Treatment of Immunoglobulin M (IgM) related peripheral neuropathy, maintenance therapy, and therapy for previously treated Waldenström's macroglobulinemia are also discussed.

Rectal Cancer, Version 3.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for the management of rectal cancer. The guideline provides recommendations regarding diagnosis, pathologic staging, surgical management, perioperative treatment, management of recurrent and metastatic disease, and patient surveillance. Outcomes of interest include safety and efficacy of treatment, adverse outcomes, and overall survival.

Bladder Cancer, Version 1.2019

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with bladder cancer. Non-muscle-invasive urothelial bladder cancer, muscle-invasive urothelial bladder cancer, metastatic (Stage IVB) urothelial bladder cancer, non-urothelial carcinomas of the bladder, upper tract urothelial carcinoma (UTUC), urothelial carcinomas of the prostate, and primary carcinomas of the urethra are all specifically discussed. The guideline provides algorithms for diagnosis, staging, treatment, and follow-up.

Chronic Myeloid Leukemia, Version 4.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with chronic myeloid leukemia (CML). The guideline discusses diagnosis and workup, staging, and management options for these patients, and includes specific considerations for children with CML. The guideline separates treatment options based on characteristics such as genetic profile, and phase (i.e. chronic phase, accelerated phase, and blast phase). Topics discussed include toxicities and response milestones for different treatment options.

T-Cell Lymphomas, Version 2.2019

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with T-cell lymphoma. The guideline examines the diagnostic workup, staging, treatment, follow-up, and supportive care for the most common subtypes of T-cell lymphoma. These subtypes include peripheral T-cell lymphomas (PTCLs), breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), mycosis fungoides (MF) and Sezary syndrome (SS), primary cutaneous CD30+ T-cell lymphoproliferative disorders, T-cell large granular lymphocytic leukemia (TGLL), adult T-cell leukemia/lymphoma (ATLL), T-cell prolymphocytic leukemia (TPLL), and extranodal NK/T-cell lymphomas (ENKL), nasal type.

Testicular Cancer, Version 2.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with testicular germ cell tumours (GCTs). The guideline examines the clinical presentation, workup, primary treatment, and pathologic diagnoses of these patients. Separate recommendations are provided for different stages of pure seminomas and nonseminomas, and the guideline also discusses second-line and subsequent therapies for metastatic GCTs.

Non-Small Cell Lung Cancer, Version 5.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with non-small cell lung cancer. The guideline examines the risk factors, classification factors, diagnostic evaluation, pathologic evaluation, staging, predictive and prognostic biomarkers, treatment, and surveillance of lung cancer. Treatment approaches considered include surgery, radiation therapy, and combined modality therapy. The discussion on initial therapy is stratified by disease stage.

Genetic/Familial High-Risk Assessment: Breast and Ovarian, Version 2.2019

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients who may be at high-risk for developing breast and ovarian cancer due to genetic/familial predispositions. The guideline provides recommendations on genetic risk assessment and genetic counseling, and specifically discusses the management of individuals with hereditary breast or breast/ovarian syndromes, including BRCA-related breast/ovarian cancer syndrome, Li-Fraumeni syndrome, and Cowden syndrome.

Prostate Cancer, Version 4.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with prostate cancer. The guideline examines various treatment options including active surveillance, radical prostatectomy, radiation therapy, other local therapies, androgen deprivation therapy, chemotherapy, and immunotherapy. It also discusses risk stratification, imaging, and estimates of life expectancy. Recommendations are provided for the initial diagnosis, clinical assessment, and staging evaluation, as well as for treatment, which are based on both the level of risk, and specific disease present.

Pancreatic Adenocarcinoma, Version 1.2019

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with pancreatic adenocarcinoma. The guideline examines risk factors and genetic predisposition, pancreatic cancer screening, diagnosis and staging, systemic therapy approaches, radiation and chemoradiation approaches, surveillance of patients with resected disease, as well as palliative and supportive care. Management of metastatic disease, locally advanced disease, resectable and borderline resectable disease, and recurrent disease after resection is also considered.

Merkel Cell Carcinoma, Version 1.2019

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with Merkel cell carcinoma. The guideline provides recommendations on diagnosis, workup, staging, radiation therapy, chemotherapy, follow-up, and recurrence. Specific recommendations are provided for the postoperative management of primary tumours, management of the draining nodal basin, and treatment of distant metastatic disease.

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 2.2019

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with chronic lymphocytic leukemia, or small lymphocytic lymphoma. The guideline examines the diagnosis, staging, treatment, and follow-up of these patients. Prognosis and treatment algorithms are presented based on patient characteristics such as age, and genetic profile.

Chronic Myeloid Leukemia, Version 1.2019

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with chronic myeloid leukemia (CML). The guideline discusses diagnosis and workup, staging, and management options for these patients, and includes specific considerations for children with CML. The guideline separates treatment options based on characteristics such as genetic profile, and phase (i.e. chronic phase, accelerated phase, and blast phase). Topics discussed include toxicities and response milestones for different treatment options.

Bone Cancer, Version 1.2019

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with bone cancer. The guideline focuses on chordoma, chondrosarcoma, Ewing sarcoma, osteosarcoma, and provides recommendations for treating giant cell tumour of the bone (GCTB). Workup, treatment, surveillance, and relapsed disease are discussed for each of the types of bone cancer mentioned. Staging, high-grade undifferentiated pleomorphic sarcoma of bone, and immunotherapy for bone cancer are also considered.

Pancreatic Cancer in Adults: Diagnosis and Management

Year: 2018
AGREE II score: Available
Developer organization: National Institute for Health and Care Excellence
This is a clinical practice guideline for adults with suspected pancreatic cancer, or those with newly diagnosed or recurrent pancreatic ductal adenocarcinoma. The guideline provides recommendations for the monitoring of people with an inherited high risk of pancreatic cancer. Recommendations are also made for diagnosis, staging, psychological support, pain and nutrition management, as well as management for resectable, borderline resectable, and unresectable cancer.

Diagnosis, Assessment and Management of Constipation in Advanced Cancer: ESMO Clinical Practice Guidelines

Year: 2018
AGREE II score: Unavailable
Developer organization: European Society for Medical Oncology
This is a clinical practice guideline for adult patients with advanced cancer who are experiencing constipation due to diagnosis or treatment. The guideline discusses the assessment, diagnosis, and management of constipation in these patients. Specific recommendations are provided for managing constipation in older adults with cancer, opioid-induced constipation, and fecal impaction. Management options considered include prevention and self-care, laxatives, suppositories, and enemas.

Delirium in Adult Cancer Patients: ESMO Clinical Practice Guidelines

Year: 2018
AGREE II score: Available
Developer organization: European Society for Medical Oncology
This is a clinical practice guideline for adults with cancer who are at risk for, or have been diagnosed with, delirium. The guideline provides recommendations regarding delirium prevention, diagnosis, screening, treatment and experiential impact. Pharmacological and non-pharmacological interventions are discussed. Guidance is also provided on education and support for the healthcare team and family members.

Guidelines for the Investigation and Management of Transient Leukaemia of Down Syndrome

Year: 2018
AGREE II score: Available
Developer organization: British Society for Haematology
This is a clinical practice guideline for children with suspected or confirmed transient leukemia of Down syndrome (TL-DS). The guideline examines the clinical features and diagnosis of TL-DS, outcomes, risk factors for early death, and treatment of TL-DS, as well as monitoring for resolution of TL-DS and development of myeloid leukemia of Down syndrome (MI-DS). Fetal TL-DS, silent TL-DS and screening for mutations in the hematopoietic transcription factor gene GATA1 are also discussed.

Soft Tissue Sarcoma, Version 2.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for the management of soft tissue sarcoma (STS) in adult patients. The guideline pertains to the following five subtypes of STS: (1) STS of extremity, superficial/trunk, or head and neck, (2) retroperitoneal or intra-abdominal STS, (3) gastrointestinal stromal tumours (GISTs), (4) desmoid tumours, and (5) rhabdomyosarcoma (RMS). The guideline provides recommendations for diagnosis, staging, treatment, palliative care, and surveillance. Surgery, chemotherapy, and radiotherapy are all examined as treatment options.

Primary Cutaneous B-Cell Lymphomas, Version 2.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
A clinical practice guideline on the diagnosis, work-up, and treatment of patients who have been diagnosed with or are suspected of having primary cutaneous B-cell lymphomas (PCBCLs). The guideline focuses on the three main types of PCBCLs: primary cutaneous marginal zone lymphoma (PCMZL), primary cutaneous follicle-center lymphoma (PCFCL), and primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL, leg type). Recommendations for treatment are provided based on lymphoma type and whether treatment is for initial, relapsed, or refractory disease.

Neuroendocrine and Adrenal Tumors, Version 2.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with neuroendocrine or adrenal tumours. The guideline discusses the diagnosis, staging, treatment, and follow-up of patients with sporadic neuroendocrine tumours, originating from organs such as the lungs, thymus, and gastrointestinal (GI) tract. The guideline also examines the role of the genetic syndrome, multiple endocrine neoplasia (MEN), in developing parathyroid, pituitary, and pancreatic tumours.

Malignant Pleural Mesothelioma, Version 2.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for malignant pleural mesothelioma (MPM). The guideline examines the clinical management options for these patients, which include surgery, radiation therapy (RT), and chemotherapy. The potential for multimodal therapy is also addressed.

Kidney Cancer, Version 4.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with renal cell carcinoma (RCC). The guideline specifically examines the initial evaluation, staging, diagnosis, clinical management options, and follow-up of patients with clear cell carcinoma and non-clear cell carcinoma. Pharmacologic agents discussed include pazopanib, sunitinib, and nivolumab.

Testicular Cancer, Version 1.2019

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with testicular germ cell tumours (GCTs). The guideline examines the clinical presentation, workup, primary treatment, and pathologic diagnoses of these patients. Separate recommendations are provided for different stages of pure seminomas and nonseminomas, and the guideline also discusses second-line and subsequent therapies for metastatic GCTs.

European Society of Endocrinology Clinical Practice Guidelines for the Management of Aggressive Pituitary Tumours and Carcinomas

Year: 2018
AGREE II score: Available
Developer organization: European Society of Endocrinology
This is a clinical practice guideline for patients with aggressive pituitary tumours and carcinomas, which provides recommendations on diagnosis, treatment, and follow-up. Treatment options such as surgery, radiotherapy, and temozolomide are examined. Further guidance on dosing regimens, adverse effects, discontinuation, and combination chemotherapies is provided for temozolomide. Recurrence, non-responders, and systemic metastasis are also discussed.

European Society of Endocrinology Clinical Practice Guidelines on the Management of Adrenocortical Carcinoma in Adults, in Collaboration With the European Network for the Study of Adrenal Tumours

Year: 2018
AGREE II score: Available
Developer organization: European Society of Endocrinology
This is a clinical practice guideline for patients with adrenocortical carcinoma (ACC). The guideline examines the diagnostic criteria and management options for ACC. Topics of interest include a discussion of the best prognostic markers for ACC, treatment options including mitotane treatment, and supportive therapies.

AASLD Guidelines for the Treatment of Hepatocellular Carcinoma

Year: 2018
AGREE II score: Available
Developer organization: American Association for the Study of Liver Diseases
This is a clinical practice guideline for hepatocellular carcinoma (HCC) occurring in adult patients with cirrhosis. The guideline examines techniques for surveillance and screening, diagnostic evaluation methods, and the various therapeutic options for the treatment of HCC. Outcomes of interest include the sensitivity and specific of screening tests, as well as morbidity, recurrence, and survival.

Gastric Cancer, Version 2.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for adults and children with gastric cancer. The guideline examines the pathology, initial workup, staging, treatment, follow-up, and supportive care of these patients. Treatment options discussed include lymph node dissection, laparoscopic resection, endoscopy, radiation therapy, combined modality therapy, chemotherapy (preoperative, perioperative, and postoperative), and targeted therapies.

Esophageal and Esophagogastric Junction Cancers, Version 2.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for adults with esophageal or esophagogastric junction cancer. The guideline examines the initial workup, histological staging, primary treatment, and follow-up of both squamous cell carcinoma and adenocarcinoma. Treatment modalities discussed include surgery, radiation therapy, combined modality therapy, chemotherapy, and targeted therapies.

Rectal Cancer, Version 2.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for the management of rectal cancer. The guideline provides recommendations regarding diagnosis, pathologic staging, surgical management, perioperative treatment, management of recurrent and metastatic disease, and patient surveillance. Outcomes of interest include safety and efficacy of treatment, adverse outcomes, and overall survival.

Acute Myeloid Leukemia, Version 1.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with acute myeloid leukemia (AML), including those with acute promyelocytic leukemia (APL). The guideline examines the initial evaluation of AML, risk stratifications based on cytogenetics and molecular markers, management options, as well as supportive care. Management strategies are separated based on whether patients are above or below sixty years of age.

Initial Diagnostic Workup of Acute Leukemia: Guideline from the College of American Pathologists and the American Society of Hematology

Year: 2017
AGREE II score: Available
Developer organization: College of American Pathologists
This is a clinical practice guideline for adults and children with acute leukemia (AL). The guideline examines laboratory testing for the initial workup of these patients, proper diagnosis, determination of prognostic factors, and possible future monitoring of ALs including acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), and acute leukemias of ambiguous lineage. Specific topics addressed include the clinical and laboratory information that should be available during the initial evaluation, the appropriate specimens and sample types used, the types of tests that should be performed for all patients as well as for subsets of patients, the location of laboratory testing, and how test results and diagnosis should be correlated and reported.

Evidence-Based Clinical Practice Guideline for the Evaluation of Potentially Malignant Disorders in the Oral Cavity: A Report of the American Dental Association

Year: 2017
AGREE II score: Available
Developer organization: American Dental Association
This is a clinical practice guideline that informs primary care clinicians about the potential use of adjuncts to the conventional visual and tactile examination (CVTE) for the evaluation of lesions, including potentially malignant disorders (PMDs), in the oral cavity. The guideline examines the diagnostic test accuracy of cytologic testing, autofluorescence, tissue reflectance, vital staining, and salivary adjuncts. Outcomes of interest include incidence of oral cancer, oral cancer survival, and quality of life.

Referral of Patients With Suspected Colorectal Cancer by Family Physicians and Other Primary Care Providers

Year: 2017
AGREE II score: Unavailable
Developer organization: Cancer Care Ontario
This clinical practice guideline provides recommendations on the referral of patients with signs and/or symptoms of colorectal cancer (CRC) by family physicians and other primary care providers. The guideline reviews signs, symptoms, and other clinical features that may be indicative of CRC and that warrant additional investigation. Referral wait time recommendations are provided, along with recommendations to reduce diagnostic delay. Additionally, known risk factors that increase the likelihood of CRC in patients with signs and/or symptoms of CRC are reviewed.

ACR Appropriateness Criteria Ovarian Cancer Screening

Year: 2017
AGREE II score: Available
Developer organization: American College of Radiology
This is a clinical practice guideline for women with average risk and high risk for ovarian cancer. The guideline examines the role of imaging during ovarian cancer screening, and its effectiveness in detecting ovarian cancer at an early stage, in order to potentially improve survival. Variations of procedures, including ultrasound (US), computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography using fluorine-18-2-fluoro-2-deoxy-D-glucose (FDG-PET), are discussed, as is their appropriateness in different clinical situations.

ACR Appropriateness Criteria Hematospermia

Year: 2017
AGREE II score: Available
Developer organization: American College of Radiology
This is a clinical practice guideline for men and adolescents with hematospermia or hemospermia. The guideline discusses imaging techniques such as transrectal ultrasound (TRUS) and magnetic resonance imaging (MRI), and their use in the identification of hematospermia's etiology. The guideline examines the appropriateness of different imaging techniques based on patient age, severity of bleeding, and presence of other relevant symptoms.

Hepatocellular Carcinoma

Year: 2017
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adults with hepatocellular carcinoma (HCC). The guideline examines the goals of therapy, and provides recommendations for the treatment of patients with different stages of HCC, from very early stages to terminal stage. Outcomes of interest include rendering the patient free of disease, preventing recurrence, and improving quality of life.

Vulvar Cancer (Squamous Cell Carcinoma), Version 1.2018

Year: 2017
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for women with vulvar cancer, and particularly those with squamous cell carcinoma (SCC) of the vulva. The guideline examines diagnosis and workup, as well as primary treatment, adjuvant radiotherapy and chemotherapy, and surveillance of these patients. Treatment options are discussed for early-stage disease, locally advanced disease, and metastases beyond the pelvis.

Guidelines for Diagnosis, Prevention and Management of Central Nervous System Involvement in Diffuse Large B-cell Lymphoma Patients by the Spanish Lymphoma Group (GELTAMO)

Year: 2017
AGREE II score: Unavailable
Developer organization: Spanish Lymphoma Group
This is a clinical practice guideline for patients with central nervous system (CNS) diffuse large B-cell lymphoma who have or at risk of developing leptomeningeal and/or brain parenchyma lymphoma relapse. The guideline examines the treatment of central nervous system involvement of lymphoma using whole-brain radiotherapy, systemic chemotherapy, intensification chemotherapy and autologous hematopoietic stem cell transplantation, and intrathecal therapy. Risk factors, diagnostic screening, and CNS prophylaxis are also discussed.

Clinical Practice Guidelines for the Management of Inherited Polyposis Syndromes

Year: 2017
AGREE II score: Unavailable
Developer organization: American Society of Colon and Rectal Surgeons
This is a clinical practice guideline for men and women with inherited polyposis syndromes. The guideline examines the identification and management of familial adenomatosis polyposis (FAP), attenuated FAP, MutY homologue-associated polyposis (MAP), and polyposis without an identified genotype. Extraintestinal manifestations included in the adenomatous polyposis syndromes are also discussed.

Diagnosis and Empirical Treatment of Fever of Unknown Origin (FUO) in Adult Neutropenic Patients: Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society Of Hematology and Medical Oncology (DGHO)

Year: 2017
AGREE II score: Unavailable
Developer organization: German Society of Hematology and Medical Oncology (DGHO)
This is a clinical practice guideline for fever of unknown origin (FUO) in adult neutropenic patients. The guideline updates recommendations for diagnosis and empirical therapy of these patients in light of the challenges of antimicrobial stewardship. Specific recommendations are provided for taking down patient history and performing a physical examination, ordering chest radiograph, and taking nasal/pharyngeal (MRSA) or rectal (VRE) swabs.

Guidelines for the Management of Febrile Neutropenia in Children

Year: 2017
AGREE II score: Unavailable
Developer organization: Atlantic Provinces Pediatric Hematology Oncology Network
This is a clinical practice guideline for the management of febrile neutropenia in children, including those with cancer, and/or those who are undergoing hematopoietic stem cell transplantation (HSCT). The guideline examines the signs and symptoms of febrile neutropenia, as well as the evaluation of affected patients. Antibiotic selection and dose are recommended based on factors related to patient's condition, including stability on presentation, presence of penicillin allergy, and current treatment. Continued management of inpatients and management based on culture results are also discussed.

EAU Guidelines on Muscle-Invasive and Metastatic Bladder Cancer

Year: 2017
AGREE II score: Available
Developer organization: European Association of Urology
This is a clinical practice guideline for the management of muscle-invasive and metastatic bladder cancer. The guideline provides recommendations on prevention, staging, imaging, diagnosis, treatment, and follow-up. Treatment options such as neoadjuvant chemotherapy, radiotherapy, and radical surgery are discussed. Other topics of interest include risk factors, comorbidities, quality of life, and pelvic organ preservation techniques.

Desmoid Tumours

Year: 2017
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients with desmoid tumours. The guideline provides recommendations for diagnosis, staging procedures, treatment, and follow-up. Treatment options including active surveillance, surgery, radiation therapy, and chemotherapy are examined. Topics of interest include desmoid tumours occurring during pregnancy, pain management, and rehabilitation.

Guidelines of Care for the Management of Cutaneous Squamous Cell Carcinoma

Year: 2017
AGREE II score: Available
Developer organization: American Academy of Dermatology
This is a clinical practice guideline for patients with cutaneous squamous cell carcinoma (cSCC). The guideline provides recommendations for the evaluation and management of patients with cSCC. Topics of interest include biopsy techniques and histopathologic assessment, tumour staging, surgical and non-surgical management, follow-up and prevention of recurrence, and management of advanced disease.

Indications for Use of Breast Magnetic Resonance Imaging (MRI)

Year: 2017
AGREE II score: Unavailable
Developer organization: Eastern Health
This is a clinical practice guideline for the appropriate use of breast magnetic resonance imaging (MRI). The guideline examines indications for breast MRI use, such as for the screening of high risk individuals, for problem solving when mammographic, sonographic or clinical findings are suspicious but inconclusive, for the assessment of positive margins following breast cancer surgery or neoadjuvant chemotherapy, and for the assessment of breast implant integrity.

3rd ESO–ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 3)

Year: 2017
AGREE II score: Unavailable
Developer organization: European School of Oncology
This is a clinical practice guideline for the management of patients with advanced breast cancer (ABC), including those with locally advanced breast cancer (LABC) and metastatic breast cancer (MBC). The guideline provides recommendations for the management of these patients, and specifically discusses the use of chemotherapy, management of bone metastases, management of cancer related fatigue, as well as supportive and palliative care.

Guidelines of Care for the Management of Basal Cell Carcinoma

Year: 2017
AGREE II score: Available
Developer organization: American Academy of Dermatology
This is a clinical practice guideline for adults who have been diagnosed with or are suspected of having basal cell carcinoma (BCC). The main focus of the guideline is on the most common approaches for the treatment of primary BCC, but it also includes recommendations on the treatment of recurrent tumours, appropriate biopsy techniques, staging, follow-up, and prevention of BCC.

EANO–ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-up of Patients with Leptomeningeal Metastasis from Solid Tumours

Year: 2017
AGREE II score: Available
Developer organization: European Society for Medical Oncology
This is a clinical practice guideline for patients with leptomeningeal metastases from solid tumours. The guideline discusses the diagnosis, treatment, and follow-up of these patients, and a treatment algorithm is presented based on life expectancy. Treatment options examined include systemic pharmacotherapy, intra-cerebrospinal fluid pharmacotherapy, focal radiotherapy (RT), and whole brain radiotherapy (WBRT).

EAU Guidelines on Urothelial Carcinoma of the Upper Urinary Tract

Year: 2017
AGREE II score: Available
Developer organization: European Association of Urology
This is a clinical practice guideline for the management of urothelial carcinoma of the upper urinary tract (UTUC). The guideline provides recommendations on diagnosis, staging, treatment, and follow-up. Prognostic factors, predictors of survival and recurrence, as well as risk stratification are also discussed. Outcomes of interest include diagnostic accuracy, overall survival, recurrence rates, and adverse effects.

Genetic/Familial High-Risk Assessment: Colorectal

Year: 2017
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for the assessment of patients who are at high risk for colorectal cancer due to genetic or familial factors. The guideline provides recommendations for the management of patients with high-risk syndromes, including Lynch syndrome, familial adenomatous polyposis (FAP), Peutz-Jeghers syndrome (PJS), Juvenile Polyposis Syndrome (JPS), Serrated Polyposis Syndrome (SPS), and other high-risk syndromes associated with colorectal cancer risk.

Early Stage Colon Cancer

Year: 2017
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients with early stage colon cancer. The guideline discusses diagnostic work-up, staging, and treatment options. Recommendations for adjuvant chemotherapy are presented, based on cancer stage.

Waldenström’s Macroglobulinemia/Lymphoplasmacytic Lymphoma, Version 1.2018

Year: 2017
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with Waldenström's macroglobulinemia or lymphoplasmacytic lymphoma. The guideline examines the diagnosis, workup, primary treatment regimens, assessment of response to primary treatment, and follow-up after primary treatment. Regimens not toxic to stem cells and regimens with potential or unknown toxicity to stem cells are considered. Treatment of Immunoglobulin M (IgM) related peripheral neuropathy, maintenance therapy, and therapy for previously treated Waldenstrom's macroglobulinemia are also discussed.

Hairy Cell Leukemia, Version 2.2018

Year: 2017
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with hairy cell leukemia. The guideline provides recommendations regarding diagnosis, initial treatment, response assessment and additional therapy, second-line therapy for relapsed/refractory or progressive disease, and supportive care. The impact of infections, such as hepatitis B (HBV) is also discussed.

Cancer Care Ontario Thyroid Cancer Guideline: An Endorsement of the 2015 American Thyroid Association Management Guidelines for Adult Patients With Thyroid Nodules and Differentiated Thyroid Cancer

Year: 2017
AGREE II score: Unavailable
Developer organization: Cancer Care Ontario
This clinical practice guideline is an endorsement of the American Thyroid Association's 2015 guideline titled Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer. The guideline provides recommendations on management of patients thyroid nodules and differentiated thyroid cancers. Topics include evaluation of thyroid nodules to determine the presence of malignancy, and management of differentiated thyroid cancer including surgery, radioactive iodine (RAI) therapy, hormonal therapy, external beam radiation therapy (EBRT), and systemic treatment.

ACR Appropriateness Criteria Evaluation of Nipple Discharge

Year: 2017
AGREE II score: Available
Developer organization: American College of Radiology
This is a clinical practice guideline for women and men of all ages who are experiencing nipple discharge. The guideline discusses different imaging modalities used to identify the causes of nipple discharge, such as mammography, digital breast tomosynthesis, ultrasound (US), magnetic resonance imaging (MRI) with or without intravenous (IV) contrast, fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission mammography (FDG-PEM), Tc-99m sestamibi molecular breast imaging (MBI), and ductography. In addition, image-guided core biopsy and image-guided fine needle aspiration are discussed as options for histologic diagnosis once suspicious lesions are identified. The guideline examines the appropriateness of these techniques for five clinical situations that are based on sex, age, and whether or not discharge is physiologic or pathologic.

Squamous Cell Skin Cancer – Version 1.2017

Year: 2017
AGREE II score: Unavailable
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for squamous cell skin cancer. Basal cell and squamous cell skin cancers, collectively known as non-melanoma skin cancers (NMSCs), are the most common cancer in the United States. The guideline provides recommendations related to clinical presentation and workup, local treatment, recurrence and metastasis, and follow-up. The guideline also provides a discussion about risk stratification and common risk factors including age, degree of differentiation, and site of prior radiotherapy.

Recommendations on Surveillance and Management of Biallelic Mismatch Repair Deficiency (BMMRD) Syndrome: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer

Year: 2017
AGREE II score: Unavailable
Developer organization: The US Multi-Society Task Force on Colorectal Cancer
This is a consensus statement providing recommendations to assist health care providers with the appropriate management of patients with biallelic mismatch repair deficiency (BMMRD) syndrome, also called constitutional mismatch repair deficiency syndrome. The guideline outlines what is known about BMMRD, the unique genetic and clinical aspects of the disease, and reviews the current management approaches taken.

Guidelines for the Use of Imaging in the Management of Patients With Myeloma

Year: 2017
AGREE II score: Available
Developer organization: British Society for Haematology
This is a clinical practice guideline for adults with myeloma. The guideline examines the use and technical application of the latest imaging modalities at diagnosis and in the follow-up of patients with myeloma and plasmacytoma. Plain X-rays, whole body low-dose computed tomography (WBLDCT), and whole body magnetic resonance imaging (WB-MRI) are imaging techniques that are focused on.

Provincial Differentiated Thyroid Cancer (DTC) Treatment Guidelines

Year: 2017
AGREE II score: Unavailable
Developer organization: Saskatchewan Cancer Agency
This is a clinical practice guideline for patients with thyroid cancer. The guideline examines the diagnosis, treatment, management, and follow-up of these patients. Topics of interest include a shift towards a standardized ultrasound/cytologic concordance system to guide investigation and management of thyroid nodules, acceptance of thyroid lobectomy as an option for many low risk thyroid cancers, acceptance of either no or lower dose radio-iodine treatment for many low risk thyroid cancers, and dynamic risk stratified follow-up for thyroid cancer.

Genetic/Familial High-Risk Assessment: Breast and Ovarian, Version 1.2018

Year: 2017
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients who may be at high-risk for developing breast and ovarian cancer due to genetic/familial predispositions. The guideline provides recommendations on genetic risk assessment and genetic counseling, and specifically discusses the management of individuals with hereditary breast or breast/ovarian syndromes, including BRCA-related breast/ovarian cancer syndrome, Li-Fraumeni syndrome, and Cowden syndrome.

Cervical Cancer, Version 1.2018

Year: 2017
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for women with cervical cancer. The guideline examines the initial diagnosis and workup, staging, primary and adjuvant treatment, surveillance, and therapy following relapse for these patients. Treatment for metastatic disease is also discussed, as are the topics of incidental cervical cancer and the occurrence of cervical cancer in pregnant women.

AIDS-Related Kaposi Sarcoma, Version 1.2018

Year: 2017
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with AIDS-related Kaposi sarcoma. The guideline examines diagnosis, staging, treatment, and follow-up, while also providing recommendations on HIV screening and HIV therapy during cancer treatment. Antiretroviral therapy (ART), topical therapies, intralesional chemotherapy, local incisions, radiation therapy, and systemic therapy are all discussed as treatment options.

Sentinel Lymph Node Biopsy and Management of Regional Lymph Nodes in Melanoma: American Society of Clinical Oncology and Society of Surgical Oncology Clinical Practice Guideline Update

Year: 2017
AGREE II score: Available
Developer organization: American Society of Clinical Oncology
This is a clinical practice guideline for adults with melanoma. The guideline examines the use of sentinel lymph node (SLN) biopsy as a method for identifying nodal metastases, and provides recommendations on which patients should receive SLN biopsy based on the size and morphology of their melanoma. The guideline also discusses the appropriateness of completion lymph node dissection (CLND) as a method of treatment.

Performance of Needle Biopsy of the Prostate for Men With Suspected or Established Prostate Cancer: Recommendation Report

Year: 2017
AGREE II score: Unavailable
Developer organization: Cancer Care Ontario
This recommendation report addresses "best practices" for prostate needle biopsies. Guidance is provided on the spectrum of prostate needle biopsy practices, including patient preparation, biopsy techniques, specimen submission to the laboratory, processing of the biopsy specimen, information to include on the requisition and pathology report, and operational issues. Facility requirements are also reviewed.

Renal Mass and Localized Renal Cancer: AUA Guideline

Year: 2017
AGREE II score: Available
Developer organization: American Urological Association
This is a clinical practice guideline for patients with localized renal masses that are suspicious for renal cell carcinoma. The guideline discusses the evaluation, diagnosis, staging, and management of these renal masses. The management options discussed include partial nephrectomy, radical nephrectomy, thermal ablation, and active surveillance.

Treatment of Patients With Waldenström Macroglobulinaemia: Clinical Practice Guidelines from the Myeloma Foundation of Australia Medical and Scientific Advisory Group

Year: 2017
AGREE II score: Unavailable
Developer organization: Myeloma Australia
This is a clinical practice guideline for patients with Waldenström macroglobulinemia (WM). The guideline examines the diagnosis and treatment of these patients. Common presentations, diagnostic criteria, prognostic markers, as well as diagnostic workup using protein studies and bone marrow biopsy are considered. Therapeutic regiments are discussed for front-line therapy of WM and treatment of relapsed WM, as well as important management aspects unique to WM.

British Gynaecological Cancer Society (BGCS) Epithelial Ovarian / Fallopian Tube / Primary Peritoneal Cancer Guidelines: Recommendations for Practice

Year: 2017
AGREE II score: Unavailable
Developer organization: British Gynaecological Cancer Society
This is a clinical practice guideline for patients with epithelial ovarian-type cancers (e.g. ovary, fallopian tube or peritoneal origin) and borderline tumours. This guideline addresses epithelial cancers of varying histological subtypes. The guideline covers the full continuum of care including screening and prevention, diagnosis, treatment options such as surgery, systemic therapy and chemotherapy, follow-up, as well as management of recurrent disease. The guideline also highlights the support needs for women with ovarian cancer.

British Association of Dermatologists’ Guidelines for the Care of Patients With Actinic Keratosis 2017

Year: 2017
AGREE II score: Available
Developer organization: British Association of Dermatologists
This is a clinical practice guideline for patients with actinic keratosis (AK). The guideline provides recommendations on treatment options such as topical therapies, cryosurgery, surgery, systemic therapy, photodynamic therapy, laser therapy, and combination treatment. Diagnosis and follow-up are also discussed.

Merkel Cell Carcinoma – Version 1.2017

Year: 2017
AGREE II score: Unavailable
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for merkel cell carcinoma. Merkel cell carcinoma is a rare, aggressive cutaneous tumor that combines the local recurrence rates of infiltrative non-melanoma skin cancer along with the regional and distant metastatic rates of thick melanoma. This guideline provides recommendations for diagnosis and workup, staging, treatment, follow-up and recurrence. Treatment recommendations include surgery, sentinel lymph node biopsy, radiation therapy, and chemotherapy as possible options.

Cutaneous Melanoma: A National Clinical Guideline

Year: 2017
AGREE II score: Available
Developer organization: Scottish Intercollegiate Guidelines Network
This is a clinical practice guideline for patients with cutaneous melanoma. The guideline examines the care of these patients throughout the cancer care continuum, including prevention and surveillance, diagnosis and prognosis, surgical management and staging, further investigations and non-surgical staging, adjuvant treatment of stage 2 and 3 melanoma, follow up of patients with stage 1, 2 and 3 melanoma, and management of advanced (unresectable stage 4 or 5) melanoma.

Guideline for the Management of Fever and Neutropenia in Children With Cancer and Hematopoietic Stem-Cell Transplantation Recipients: 2017 Update

Year: 2017
AGREE II score: Available
Developer organization: International Pediatric Fever and Neutropenia Guideline Panel
This is a clinical practice guideline for the empirical management of fever and neutropenia (FN) in children with cancer, and those who have received hematopoietic stem-cell transplantation (HSCT). The guideline examines initial presentation, ongoing management, and empirical antifungal therapy. Topics of interest include risk stratification to define patients with high-risk invasive fungal disease (IFD), recommended biomarkers and radiologic investigations for the evaluation of IFD in prolonged FN, and empirical antifungal therapy in IFD low-risk patients with prolonged FN.

Guidance for the Management of Gynecologic Sarcomas in Ontario: Recommendations Report 2017

Year: 2017
AGREE II score: Unavailable
Developer organization: Cancer Care Ontario
This recommendations report provides guidance on the investigation and management of suspected or proven pelvic and extra-pelvic gynecologic sarcomas. Recommendations are made on the use of pathology during investigation, while recommendations pertaining to treatment focus on surgery and adjuvant therapy. The guidance document also provides recommendations on a number of quality assurance measures to assess gynecologic sarcoma services.

ACR Appropriateness Criteria Suspected Liver Metastases

Year: 2017
AGREE II score: Available
Developer organization: American College of Radiology
This is a clinical practice guideline for the assessment of liver metastases. The guideline provides recommendations regarding the appropriateness of imaging modalities and the optimization of imaging parameters for specific clinical scenarios, including diagnosis, staging, and surveillance. Outcomes of interest include accuracy in characterizing and detecting liver lesions, length of examination, and potential adverse health effects, as well as surveillance sensitivity, specificity, and reproducibility.

EAU Guidelines on Renal Cell Carcinoma

Year: 2017
AGREE II score: Available
Developer organization: European Association of Urology
This is a clinical practice guideline for adult patients with renal cell carcinoma (RCC). The guideline examines the staging, diagnosis, prognosis, treatment, and follow-up of these patients. Management recommendations are provided for treating localized RCC, locally advanced RCC, advanced/metastatic RCC, and recurrent RCC. The epidemiology, etiology, and pathology of RCC are also discussed.

EAU Guidelines on Non-Muscle-Invasive Bladder Cancer (TaT1 and CIS)

Year: 2017
AGREE II score: Available
Developer organization: European Association of Urology
This is a clinical practice guideline for the management of non-muscle-invasive bladder cancer. Recommendations are provided for diagnosis, staging, treatment, and follow-up. The guideline also discusses how to predict the short-term and long-term risks of disease recurrence and progression, as well as the stratification of patients into risk groups. Treatment options are presented based on these risk groups. Management of side effects is also discussed.

ECIL-6 Guidelines for the Treatment of Invasive Candidiasis, Aspergillosis and Mucormycosis in Leukemia and Hematopoietic Stem Cell Transplant Patients

Year: 2017
AGREE II score: Unavailable
Developer organization: European Conference on Infections in Leukemia (ECIL)
This is a clinical practice guideline for patients with hematologic malignancies or recipients of hematopoietic stem cell transplantation. The guideline examines diagnostic strategies as well as prophylactic, pre-emptive or targeted therapy for various types of infections in these patients. Invasive candidiasis or aspergillosis infections, and mucormycosis are discussed. Both first-line treatment and salvage and maintenance therapy are addressed.

BGCS Uterine Cancer Guidelines: Recommendations for Practice

Year: 2017
AGREE II score: Unavailable
Developer organization: British Gynaecological Cancer Society
This is a clinical practice guideline for women with uterine cancer. The guideline provides recommendations for the screening and prevention of uterine cancer in the general population and in high risk groups, as well as for the pathological work-up, management, and follow-up of patients with uterine cancer. Specific conditions discussed include endometrioid endometrial cancer, as well as non-endometrioid cancers such as uterine serous carcinoma, uterine clear cell carcinoma, and uterine carcinosarcoma.

Diagnosis and Management of Waldenström Macroglobulinemia: Mayo Stratification of Macroglobulinemia and Risk-Adapted Therapy (mSMART) Guidelines 2016

Year: 2017
AGREE II score: Unavailable
Developer organization: Mayo Clinic
This is a clinical practice guideline for patients with Waldenström macroglobulinemia (WM). The guideline discusses a risk-adapted approach to the management of WM, using a grading system. Topics of interest include diagnosis, risk stratification and response assessment, initial therapy, as well as subsequent therapy.

Renal Cell Carcinoma

Year: 2017
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients with renal cell carcinoma (RCC). The guideline examines the clinical management of RCC, including diagnosis, treatment, and follow up. The primary outcomes of interest are survival, recurrence, and quality of life.

Occult Primary (Cancer Of Unknown Primary [CUP]), Version 1.2018

Year: 2017
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with epithelial occult primary cancer. The guideline provides recommendations for the evaluation, workup, management, and follow-up of two pathologic diagnoses in patients with epithelial occult primary cancer: adenocarcinoma, or carcinoma not otherwise specified (NOS), and squamous cell carcinoma (SCC). Management options considered include, chemotherapy, radiation therapy, locoregional therapeutic options, and specialized approaches, as well as supportive care and management of psychosocial distress.

Myeloproliferative Neoplasms, Version 2.2018

Year: 2017
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with myeloproliferative neoplasms. The guideline specifically examines the diagnosis, risk-stratification, treatment, and supportive care for patients with polycythemia vera (PV), essential thrombocythemia (ET) and myelofibrosis (MF). Risk-stratified treatment algorithms are provided for each disorder.

Lung Cancer Screening – Version 1.2017

Year: 2017
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for lung cancer screening in adult patients. The guideline reviews risk factors for lung cancer and provides recommendations on selecting high-risk individuals for screening, guidance on choice of screening modalities with specific review of low dose computed tomography (LDCT), and recommendations on the evaluation and follow-up of nodules found during screening. Additionally, the benefits and risks of screening are discussed.

EAU – ESTRO – ESUR – SIOG Guidelines on Prostate Cancer

Year: 2017
AGREE II score: Available
Developer organization: European Association of Urology
This is a clinical practice guideline for adult patients with prostate cancer. The guideline examines the screening, diagnosis, staging, treatment, and follow-up of these patients. Treatment options considered include deferred treatment, radical prostatectomy, definitive radiotherapy, and hormonal therapy. Management of metastatic prostate cancer, prostate cancer in older men, prostate-specific antigen-only recurrence after treatment, and castration-resistant prostate cancer are also discussed, as well as the epidemiology and etiology of prostate cancer, and quality of life outcomes.

EAU Guidelines on Primary Urethral Carcinoma

Year: 2017
AGREE II score: Available
Developer organization: European Association of Urology
This is a clinical practice guideline for patients with primary urethral carcinoma (UC). The guideline provides recommendations on the diagnosis and treatment of UC. Staging and classification systems for UC are also discussed. Outcomes of interest include detection rate, overall survival, complications, and toxicity.

Management of Pancreatic Cancer Part 2: Diagnosis

Year: 2017
AGREE II score: Available
Developer organization: Belgian Healthcare Knowledge Centre
This clinical practice guideline is part two of a series focusing on the management of pancreatic cancer (PC). The guideline focuses on the diagnosis of pancreatic cancer, and provides recommendations regarding imaging tests such as endoscopic ultrasound (EUS), positron emission tomography (PET), and laparoscopy. The use of serum biomarkers during diagnostic work-up, and tests to assess curative resectability of pancreatic tumours, are also discussed.

Management of Chronic Myeloid Leukemia 

Year: 2017
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline on the diagnosis, staging, treatment and management of adult patients who are suspected of having, or have been diagnosed with, chronic myelogenous leukemia (CML). Treatment options examined include the use of tyrosine kinase inhibitors (TKIs) such as imatinib, nilotinib, dasatinib, bosutinib, and ponatinib, as well as allogeneic stem cell transplant (SCT) and Interferon-a (IFNa). Special consideration is paid to the use of TKIs in the treatment of elderly patients with CML.

Adolescent and Young Adult (AYA) Oncology, Version 2.2018

Year: 2017
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for adolescents and young adults with cancer. The guideline discusses risk factors, screening, diagnosis, management, follow-up, supportive care, and palliative care for patients between 15 and 39 years of age. Unique issues discussed include adherence to treatment, the impact of cancer and its treatment on fertility, management of cancer during pregnancy, relationship management, and socioeconomic issues.

Diagnosis and Treatment of Brain Metastases from Solid Tumours: Guidelines from the European Association of Neuro-Oncology (EANO)

Year: 2017
AGREE II score: Unavailable
Developer organization: European Association of Neuro-Oncology
This is a clinical practice guideline for patients with brain metastases from solid tumours. The guideline examines the diagnosis of these patients using neuroimaging and neuropathology, as well as various treatment options including surgery, stereotactic radiosurgery/stereotactic fractionated radiotherapy, whole-brain radiotherapy, chemotherapy, and targeted therapy. Staging, prognostic factors, and supportive care for these patients are also addressed.

Quality Standards in Upper Gastrointestinal Endoscopy: A Position Statement of the British Society of Gastroenterology (BSG) and Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland (AUGIS)

Year: 2017
AGREE II score: Available
Developer organization: British Society of Gastroenterology
This is a clinical practice guideline on the use of endoscopy for the diagnosis of upper gastrointestinal (UGI) cancers. Pre-procedural, procedural, post-procedural, and disease-specific recommendations are provided. The primary outcome of interest is to optimize the diagnosis of early neoplasia and premalignant conditions of the upper gastrointestinal tract, in order to reduce the effects of UGI cancers which are often associated with a poor prognosis due to late detection.

European Thyroid Association Guidelines Regarding Thyroid Nodule Molecular Fine-Needle Aspiration Cytology Diagnostics

Year: 2017
AGREE II score: Unavailable
Developer organization: European Thyroid Association
This is a clinical practice guideline for patients with thyroid nodules. The guideline provides recommendations on molecular fine-needle aspiration (FNA) cytology diagnostics, and discusses topics such as the use of microarray gene expression classifier (GEC) tests, mutation panel assessments, and targeted next-generation sequencing (tNGS). Outcomes of interest include reductions in diagnostic lobectomies, and improved surgical decision-making.

Clinical Practice Guideline: Evaluation of the Neck Mass in Adults

Year: 2017
AGREE II score: Available
Developer organization: American Academy of Otolaryngology
This is a clinical practice guideline for the evaluation of neck masses in adults. The guideline provides recommendations for the efficient, effective, and accurate diagnostic workup of neck masses to ensure that adults with potentially malignant disease receive prompt diagnosis and intervention to optimize outcomes. Specific goals include reducing delays in the diagnosis of head and neck squamous cell carcinoma (HNSCC), promoting appropriate testing, reducing inappropriate testing, and promoting appropriate physical examination when cancer is suspected

Basal Cell Skin Cancer – Version 1.2017

Year: 2017
AGREE II score: Unavailable
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for basal cell skin cancer. The guideline considers clinical presentation and workup, local treatment, recurrence and metastasis, and follow-up. The guideline also includes a discussion about risk stratification and explores different risk factors for basal cell skin cancer including location and size, age, and site of prior radiotherapy.

Referral of Suspected Prostate Cancer by Family Physicians and Other Primary Care Providers

Year: 2016
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline on the diagnosis of prostate cancer. The guideline examines effective diagnostic methods and provides recommendations on testing and referrals. Outcomes of interest include diagnostic accuracy, sensitivity, and specificity. Other topics of discussion include factors associated with delayed referral and risk factors that are predictive of prostate cancer.

Clinical Practice Guidelines for the Management of Adult Onset Sarcoma

Year: 2016
AGREE II score: Available
Developer organization: Cancer Council Australia
A clinical practice guideline for the management of adult onset sarcoma. The guideline examines the diagnosis, staging, treatment, and follow-up options for sarcoma. Imaging modalities for the purpose of diagnosis and staging are compared, while the importance of multidisciplinary care and the effects of delayed referrals to specialists are discussed. In addition, pre-operative and post-operative radiotherapy are compared, and the guideline also examines adjuvant and systemic chemotherapy, as well as surgical procedures. This guideline is wiki-based and is constantly updated as new evidence arises - this review pertains to the guideline as of April 23, 2018.

Evaluation and Management of Adnexal Masses

Year: 2016
AGREE II score: Unavailable
Developer organization: American College of Obstetricians and Gynecologists
This is a clinical practice guideline for patients with suspected or incidentally diagnosed adnexal masses. The guideline discusses the use of ultrasonography and serum marker testing during initial evaluation, which findings indicate malignant versus benign masses, and the appropriate situations for surgery versus observation. Specific recommendations are also provided for adolescents and pregnant women.

CNS Infections in Patients With Hematological Disorders (Including Allogeneic Stem-Cell Transplantation)—Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO)

Year: 2016
AGREE II score: Unavailable
Developer organization: German Society of Hematology and Medical Oncology (DGHO)
This is a clinical practice guideline for patients with hematological malignancies including allogeneic hematopoietic stem-cell transplantation (allo-HSCT) recipients. The guideline provides recommendations for the management of central nervous system infections in these patients. Specific topics addressed include epidemiology and causative agents, pathogenesis, prophylaxis, diagnosis, antimicrobial treatment, and adjunctive treatment.

European Society of Endocrinology Clinical Practice Guideline for Long-Term Follow-Up of Patients Operated on for a Phaeochromocytoma or a Paraganglioma

Year: 2016
AGREE II score: Available
Developer organization: European Society of Endocrinology
This is a clinical practice guideline for patients who have been operated on for a pheochromocytoma or a paraganglioma. The guideline discusses the long-term follow-up of these patients, and includes recommendations on diagnosing malignancy, perioperative work-up, duration of follow-up, monitoring methods, as well as specific considerations for pregnant women and patients who are frail and/or elderly.

Non-Hodgkin’s Lymphoma: Diagnosis and Management

Year: 2016
AGREE II score: Available
Developer organization: National Institutes of Health
This guideline covers diagnosing and managing non-Hodgkin's lymphoma in people aged 16 years and over. It aims to improve care for people with non-Hodgkin's lymphoma by promoting the best tests for diagnosis and staging and the most effective treatments for 6 of the subtypes: follicular lymphoma, MALT lymphoma, mantle cell lymphoma, diffuse large B-cell lymphoma, Burkitt lymphoma, and peripheral T-cell lymphoma. Tests and treatments covered include excision biopsy, radiotherapy, immunochemotherapy and stem cell transplantation.

Ovarian Cancer: Diagnosis, Treatment and Follow-up

Year: 2016
AGREE II score: Available
Developer organization: Belgian Health Care Knowledge Centre
This clinical practice guideline provides recommendations for the diagnosis, treatment, and follow-up of epithelial ovarian cancer. This guideline covers: carcinoma of the ovary, fallopian tube and primary peritoneal carcinoma; epithelial carcinoma, e.g. serious, mucinous, clear cell or endometrioid histology; borderline and invasive disease, diagnosis and first-line treatment; and follow-up after treatment. Recommendations consider patient values and preferences when treated for ovarian cancer.

Gastrointestinal Stromal Tumours (GIST)

Year: 2016
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for patients with gastrointestinal stromal tumours. The guideline examines appropriate imaging modalities, and treatment for newly diagnosed and metastatic tumours. Outcomes of interest include disease progression and recommended imaging.

Chronic Lymphocytic Leukemia

Year: 2016
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for adult patients with chronic lymphocytic leukemia. The guideline examines diagnosis, staging, and treatment of newly diagnosed, relapsed, and refractory leukemia. Outcomes of interest include progression-free survival, reduced adverse events, and treatment response.

Older Adult Oncology – Version 2.2016

Year: 2016
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This clinical practice guideline discusses specific issues related to the management of cancer in adults aged 65 years or older. Topics include screening and comprehensive geriatric assessment (CGA), assessing risks and benefits of treatment, preventing or decreasing complications from therapy, and managing disease-specific issues. Recommendations are also provided for management of patients deemed to be at high risk for toxicity from standard treatment.

Non-Hodgkin’s Lymphomas – Version 3.2016

Year: 2016
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for Non-Hodgkin's Lymphomas (NHL). The guideline focuses on recommendations for diagnostic workup, treatment, and surveillance strategies for the most common subtypes of NHL, in addition to a general discussion on the classification systems used in NHL and supportive care considerations. The most common NHL subtypes that are covered in the guideline are: Mature B-cell lymphomas, Mature T-cell and NK-cell lymphomas, Post Transplant Lymphoproliferative Disorders (PTLD), and Castleman's Disease.

Multiple Myeloma – Version 2.2017

Year: 2016
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for multiple myeloma. The guideline addresses diagnosis, treatment, and follow-up care. It offers specific recommendations for primary therapy, surveillance and follow-up tests for solitary plasmacytoma, smoldering (asymptomatic) myeloma, active (symptomatic) multiple myeloma, as well as for transplant and non-transplant candidates.

Bone Cancer – Version 1.2017

Year: 2016
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This clinical practice guideline reviews workup and treatment of bone cancer, with specific recommendations provided for chondrosarcoma, chordoma, Ewing's sarcoma family of tumors, and osteosarcoma. Surveillance and relapse is also reviewed. An overview of systemic therapy agents is provided, and principles of radiation therapy are discussed.

Acute Myeloid Leukemia – Version 2.2016

Year: 2016
AGREE II score: Unavailable
Developer organization: National Comprehensive Cancer Network
This clinical practice guideline provides recommendations for the diagnosis and treatment of acute myeloid leukemia (AML). Induction therapy and post-remission (consolidation) therapy are reviewed with recommendations stratified by risk and age. Specific recommendations are provided for the management of acute promyelocytic leukemia (APL). The guideline also discusses therapy for relapse, evaluation and treatment of CNS leukemia, and supportive care.

Non-Small Cell Lung Cancer – Version 4.2016

Year: 2016
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for adult patients with non-small cell lung cancer. The guideline provides updated recommendations around prevention and screening, evaluation and staging, treatment, and follow up care. Areas of focus are discussed with recognition that much progress has been made in regards to screening, minimally invasive techniques for diagnosis and treatment, advances in radiation therapy (RT) including stereotactic ablative radiotherapy (SABR), and targeted therapies.

Prostate Cancer – Version 3.2016

Year: 2016
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This clinical practice guideline reviews diagnostic assessment and management of prostate cancer. The guideline discusses risk stratification, molecular testing, and imaging for clinical assessment and staging workup. Management options reviewed include observation, active surveillance, radical prostatectomy, radiation therapy, androgen deprivation therapy, chemotherapy, and immunotherapy, with treatment recommendations stratified by risk. Outcomes of interest include survival and adverse effects of treatment.

ACR Appropriateness Criteria Borderline and Unresectable Pancreas Cancer

Year: 2016
AGREE II score: Available
Developer organization: American College of Radiology
This clinical practice guideline provides recommendations on the diagnosis and treatment of locally advanced and borderline resectable pancreatic cancer. Radiotherapy alone is compared to chemoradiation for treatment of locally advanced disease, and preoperative therapy for borderline resectable disease is discussed. The guideline reviews neoadjuvant systemic therapy followed by local treatment and provides recommendations on chemotherapy regimes. Outcomes of interest include progression-free survival, median survival, 1-year survival, and local control.

Cancer of the Upper Aerodigestive Tract: Assessment and Management in People Aged 16 and Over

Year: 2016
AGREE II score: Available
Developer organization: National Institute for Health and Care Excellence
This clinical practice guideline provides recommendations on the investigation, treatment, and follow-up care of patients aged 16 years and older with cancer of the upper aerodigestive tract. HPV-related disease and less common upper aerodigestive tract cancers including carcinoma of the nasopharynx or paranasal sinuses, unknown primary of presumed upper aerodigestive tract origin, and mucosal melanoma, are also reviewed. Additionally, recommendations are provided on optimizing rehabilitation and function. Outcomes of interest include prevalence, predictive value, sensitivity, specificity, local control, survival (overall, progression-free), treatment-related morbidity and mortality, and resource use, among others.

Clinical practice guidelines PSA Testing and Early Management of Test-Detected Prostate Cancer

Year: 2016
AGREE II score: Available
Developer organization: Prostate Cancer Foundation of Australia
A clinical practice guideline for middle-aged and older men at risk for prostate cancer who are considering, or have decided to have, a PSA test. The guideline examines supporting informed decision making for PSA testing, recommended protocols, and diagnosis and management for abnormal results. Outcomes of interest include reducing over-diagnosis and improved cumulative mortality.

Use of Biomarkers to Guide Decisions on Adjuvant Systemic Therapy for Women With Early-Stage Invasive Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline

Year: 2016
AGREE II score: Available
Developer organization: American Society of Clinical Oncology
This is a clinical practice guideline for women with early-stage invasive breast cancer. The guideline provides recommendations on use of breast tumour biomarker assay results to inform decisions on adjuvant therapy. Several markers are reviewed including 21 gene recurrence score (Oncotype DX), 12 gene risk score (EndoPredict), 70 gene assay (MammaPrint), 50 gene subtype predictor (PAM50 Risk of Recurrence), Breast Cancer Index (BCI), 5 protein panel risk specification (Mammostrat), immunohistochemistry 4 (IHC-4), urokinase plasminogen activator and plasminogen activator inhibitor type 1 (uPA and PAI-1), circulating tumour cells (CTCs), tumour-infiltrating lymphocytes (TILs), and protein encoded by the MKI67 gene. Additionally, the guideline provides recommendations on the use of specific biomarkers to guide choice of specific drugs and regimes. Outcomes of interest include overall survival and disease-free or recurrence-free survival.

SEOM Clinical Guideline for Gastrointestinal Sarcomas (GIST) (2016)

Year: 2016
AGREE II score: Unavailable
Developer organization: Spanish Society of Medical Oncology
This is a clinical practice guideline for the diagnosis, treatment and follow-up of patients with gastrointestinal stromal tumours (GISTs). The guideline discusses the diagnosis of GISTs using radiology, histology and molecular biology, while also providing recommendations for the treatment of both localized and advanced disease. Surgery, adjuvant and neoadjuvant treatment options are specifically examined.

ECIL Guidelines for Preventing Pneumocystis Jirovecii Pneumonia in Patients With Haematological Malignancies and Stem Cell Transplant Recipients

Year: 2016
AGREE II score: Unavailable
Developer organization: European Conference on Infections in Leukemia (ECIL)
This is a clinical practice guideline for patients with hematological disorders who are at risk for Pneumocystis jirovecii pneumonia (PCP). The guideline focuses on the prevention of PCP, and specifically examines PCP diagnosis, prophylaxis and treatment. Differences in clinical presentations between hematology patients and other immunocompromised populations, especially HIV-infected patients, are discussed.

CGCG Clinical Practice Guidelines for the Management of Adult Diffuse Gliomas

Year: 2016
AGREE II score: Unavailable
Developer organization: Chinese Glioma Cooperative Group
This is a clinical practice guideline for adults with diffuse gliomas. Diagnosis, as well as treatment methods including chemotherapy, radiation therapy, and surgical procedures are discussed. The guideline provides general recommendations, as well as specific recommendations for low grade gliomas (WHO grade II), anaplastic gliomas (WHO grade III), and glioblastoma (WHO grade IV).

Technical Aspects of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration

Year: 2016
AGREE II score: Available
Developer organization: American College of Chest Physicians
This is a clinical practice guideline for patients undergoing endobronchial ultrasound (EBUS) for the real-time guidance of transbronchial needle aspiration (TBNA) of mediastinal and hilar structures and parabronchial lung masses. The guideline discusses the technical aspects of linear EBUS-TBNA, including patient factors (e.g. sedation), procedural aspects (e.g. ultrasonographic features of lymph nodes, needle size, number of needle passes, use of suction, and presence of rapid on-site cytologic evaluation), and proceduralists' aptitude (i.e. training) are specifically addressed.

Low-Grade Gliomas

Year: 2016
AGREE II score: Available
Developer organization: Alberta Health Services
This is a clinical practice guideline for adults with low-grade gliomas (LGGs). The guideline examines the diagnosis, prognosis, and treatment of these patients. Treatment modalities discussed include surgery, radiation therapy, and chemotherapy.

Bone Marrow Synoptic Reporting for Hematologic Neoplasms: Guideline from the College of American Pathologists Pathology and Laboratory Quality Center

Year: 2016
AGREE II score: Available
Developer organization: College of American Pathologists
This is a clinical practice guideline aiming to standardize the basic components of a synoptic report template for the bone marrow samples of patients with hematological neoplasms, such as acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), myelodysplastic syndromes (MDSs), myeloproliferative neoplasms (MPNs), plasma cell disorders, Hodgkin lymphoma, and non-Hodgkin lymphoma (NHL). Reports would address the following domains: bone marrow morphologic descriptors, possible tests (by category) to be performed on the primary sample, relevant clinical and laboratory information, necessary components (regulatory, legal, financial, among others), and layout.

Clinical Utility of Multigene Profiling Assays in Invasive Early-Stage Breast Cancer

Year: 2016
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for women diagnosed with invasive early-stage breast cancer. The guideline discusses the use of different multigene profiling assays for determining risk profiles (high-risk vs low-risk) in patients with estrogen receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative tumours. The validity and clinical utility of different assays are examined, including Oncotype DX, Prosigna, MammaPrint, EndoPredict, and EPclin. In addition, assays are specifically compared to Oncotype DX, the only assay that was publicly funded and part of standard practice in Ontario at the time of publication.

Malignant Biliary Obstruction

Year: 2016
AGREE II score: Available
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients with neoplasms causing biliary obstruction. The guideline examines the management of malignant biliary obstructions, including diagnostic work-up and treatment options. Recommendations are provided based on factors such as the resectability and location of the obstruction. Outcomes of interest include improved quality of life (QOL) and prolonged survival.

Guidelines for the Investigation of Patients With Symptoms Suggestive of Colorectal Cancer

Year: 2016
AGREE II score: Unavailable
Developer organization: Cancer Care Nova Scotia
This is a clinical practice guideline for adult patients in primary care settings or emergency departments who have signs and symptoms suggestive of colorectal cancer (CRC). The guideline examines how to define expectations for primary care providers (PCPs), endoscopists, and radiologists regarding the appropriate work up of patients who have symptoms suggestive of colorectal cancer, and outlines the communication expectations between PCPs, endoscopists, radiologists, and other health care providers and patients. Outcomes of interest include effective communication, as well as early and accurate diagnoses.

Consensus Recommendations for Management of Malignant Melanoma

Year: 2016
AGREE II score: Unavailable
Developer organization: Cancer Care Manitoba
This is a clinical practice guideline for the clinical management of malignant melanoma with the aim of improving the standard of care received by this patient population. The guideline provides recommendations on referral to surgeons and associated wait times, procedures (e.g., biopsy), tumour markers, and adjuvant therapies.

Diagnosis and Treatment of Non-muscle Invasive Bladder Cancer: AUA/SUO Guideline

Year: 2016
AGREE II score: Available
Developer organization: American Urological Association
This is a clinical practice guideline for patients with non-muscle invasive bladder cancer. Recommendations are provided on diagnostic procedure, risk stratification, variant histologies, urine markers, and treatment options including TURBT/Repeat resection, intravesical therapy, BCG/maintenance, and chemotherapy BCG combinations. BCG relapse and salvage regimens are reviewed as is the role of cystectomy and cystoscopy. Additionally, recommendations are provided for risk adjusted surveillance and follow-up strategies.

Breast Cancer Screening and Diagnosis – Version 1.2016

Year: 2016
AGREE II score: Unavailable
Developer organization: National Comprehensive Cancer Network
A clinical practice guideline for women who may be at risk for breast cancer or who qualify for breast cancer screening. The guideline examines screening for average and increased risk, and diagnostic evaluation including mammography, MRI, ultrasound, and tissue biopsy. Outcomes of interest include adverse events, delayed diagnosis, and probability of malignancy.

Soft Tissue Sarcoma – Version 1.2017

Year: 2016
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for soft tissue sarcoma. The guideline examines diagnosis, treatment and follow up. Various stages are addressed, as well as a various treatment options and disease progression. Guidance is presented for specific issues (e.g., gastrointestinal stromal tumors).

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma – Version 1.2017

Year: 2016
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for chronic lymphocytic leukemia/ small lymphocytic lymphoma. This guideline provides recommendations relating to diagnosis, prognostic factors, workup, staging, and response criteria. It also provides recommendations as they pertain to treatment options, which include discussions about first-line therapy, relapsed or refractory therapy, as well as assessment of functional status and comorbidity.

Cancer-Related Fatigue – Version 1.2016

Year: 2016
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients (children/adolescents and adults) who are experiencing cancer-related fatigue. The guideline discusses evaluation and intervention for patients on active treatment, post-treatment, and at end of life. Education and counselling, nonpharmacologic interventions, and pharmacologic interventions are all discussed along with general strategies for management of fatigue.

Gastric Cancer – Version 3.2016

Year: 2016
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for gastric cancer. The guideline provides an evidence- and consensus-based treatment approach for the management of patients with gastric cancer. Topic areas discussed within the guideline include: staging, principles of pathology, surgery, endoscopic therapies, radiation therapy, combined modality therapy, chemotherapy, and follow-up.

Guidelines for the Diagnosis and Referral of Suspected Lung Cancer

Year: 2016
AGREE II score: Unavailable
Developer organization: Cancer Care Nova Scotia
This is a clinical practice guideline for the investigation and diagnosis of suspected lung cancer and referral for treatment, particularly for patients residing in Nova Scotia. The guideline reviews the investigation process from initial presentation to treatment referral. Topics include principles of communication between patient-provider and among providers throughout the diagnostic process, standards for initial investigation, appropriate use of imaging (CT, MRI, PET, bone scan) and biopsy and laboratory testing, as well as recommendations regarding treatment referral upon diagnosis. Referrals to diagnostic specialists (thoracic surgery or respirology) and to psychosocial and supportive care are also reviewed.

Rectal Cancer – Version 2.2016

Year: 2016
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with colon cancer. The guideline reviews risk assessment, TNM staging, and pathology, and provides recommendations on the clinical presentation and treatment of nonmetastatic disease as well as recommendations on management of metastatic disease. Treatment for locally recurrent disease and survivorship are also discussed, as is the role of vitamin D in colorectal cancer.

ACR Appropriateness Criteria Management of Recurrent Endometrial Cancer

Year: 2016
AGREE II score: Available
Developer organization: American College of Radiology
A clinical practice guideline for adult patients with recurrent endometrial cancer. The guideline examines management, including re-staging workups, and treatment through salvage radiotherapy and surgical intervention. Outcomes of interest include improved local control and 5-year survival rates through external beam radiation and brachytherapy.

Bladder Cancer – Version 2.2016

Year: 2016
AGREE II score: Unavailable
Developer organization: National Comprehensive Cancer Network
This clinical practice guideline discusses evaluation, treatment (primary and secondary) options, and follow-up care for patients with bladder cancer. Specific workup and treatment recommendations are provided for non-muscle invasive disease, muscle invasive disease, upper genitourinary tract (GU) tumours, urothelial carcinomas of the prostate, primary carcinoma of the urethra. Non-urothelial carcinomas of the bladder are also discussed.

The Role of Endoscopy in the Evaluation and Management of Patients With Solid Pancreatic Neoplasia

Year: 2016
AGREE II score: Unavailable
Developer organization: American Society for Gastrointestinal Endoscopy
This clinical practice guideline discusses the evaluation and treatment of patients with suspected solid pancreatic neoplasia. The guideline reviews presentation and clinical evaluation of pancreatic neoplasia, and provides an overview of radiologic and endoscopic modalities for adenocarcinoma of the pancreas, neuroendocrine tumours (NETS) of the pancreas, solid pseudopapillary tumours (SPTs), metastatic disease, and lymphoma. Screening for pancreatic cancer is also discussed. Outcomes of interest include sensitivity and specificity, as well as adverse events.

SEOM Clinical Guideline of Management of Soft-Tissue Sarcoma (2016)

Year: 2016
AGREE II score: Unavailable
Developer organization: Spanish Society of Medical Oncology
This is a clinical practice guideline for patients with soft-tissue sarcoma (STS). The guideline examines the therapeutic decision-making processes used for the management of STS in order to improve patient care. Recommendations are provided for staging, diagnosis, and treatment.

EANO Guidelines for the Diagnosis and Treatment of Meningiomas

Year: 2016
AGREE II score: Unavailable
Developer organization: European Association of Neuro-Oncology
This is a clinical practice guideline for patients with meningiomas. Recommendations are provided regarding diagnosis, including radiological methods used, collection and storage of tissue, and histological verification. Different treatment and follow-up recommendations are also discussed, based on which World Health Organization (WHO) grade the meningioma is classified as (i.e. WHO grades I-III).

Management of Viral Hepatitis in Patients With Haematological Malignancy and in Patients Undergoing Haemopoietic Stem Cell Transplantation: Recommendations of the 5th European Conference on Infections In Leukaemia (ECIL-5)

Year: 2016
AGREE II score: Unavailable
Developer organization: European Conference on Infections in Leukemia (ECIL)
This is a clinical practice guideline for the management of viral hepatitis in patients with hematological malignancy and in patients undergoing haemopoietic stem cell transplantation. The guideline examines the screening, vaccination, and treatment options for these conditions. Primary outcomes of interest include the prevention of viral reactivation, and increasing overall survival.

Community Acquired Respiratory Virus Infections in Cancer Patients – Guideline on Diagnosis and Management by the Infectious Diseases Working Party of the German Society for Haematology and Medical Oncology

Year: 2016
AGREE II score: Unavailable
Developer organization: German Society of Hematology and Oncology (DGHO)
This is a clinical practice guideline for cancer patients with community-acquired respiratory virus (CRV) infections. The guideline examines the diagnosis of CRV infections using virology and radiology techniques, as well as the management of CRV infection with infection control and supportive measures. Causal treatment is also discussed for influenza, respiratory syncytial virus (RSV), parainfluenza (PIV), adenovirus, human metapneumovirus (hMPV), rhinovirus, coronavirus, and others.

Diagnosis, Prevention, and Management of Bleeding Episodes in Philadelphia-Negative Myeloproliferative Neoplasms: Recommendations by the Hemostasis Working Party of the German Society Of Hematology And Medical Oncology (DGHO) and the Society of Thrombosis and Hemostasis Research (GTH)

Year: 2016
AGREE II score: Unavailable
Developer organization: German Society of Hematology and Oncology (DGHO)
This is a clinical practice guideline for patients with myeloproliferative neoplasms (MPN). The guideline examines the diagnosis, management, and prevention of severe bleeding complications in patients diagnosed with classic Philadelphia chromosome negative (Ph-negative) MPN. Bleeding due to alterations of primary hemostasis, secondary hemostasis, and vascular alterations are discussed. Management of elective surgery in MPN patients is also examined.

ACR Appropriateness Criteria Hodgkin Lymphoma — Stage III and IV

Year: 2016
AGREE II score: Available
Developer organization: American College of Radiology
A clinical practice guideline for patients with newly diagnosed stage III or IV Hodgkin lymphoma. The guideline examines diagnosis, primarily through biopsy, and treatment options focusing primarily on chemotherapy. Outcomes of interest include increased toxicity using both mechlorethamine, vincristine, procarbazine, and prednisone and doxorubicin, bleomycin, and vinblastine hybrid treatment.

Clinical Practice Guidelines for Teleoncology

Year: 2016
AGREE II score: Available
Developer organization: Clinical Oncological Society of Australia
This is a clinical practice guideline for teleoncology models of care. Teleoncology seeks to offer solutions to some of the access issues faced by patients and health professionals from regional, rural and remote communities around the world. The focus of the guideline is shaped by a number of clinical questions that include: what teleoncology models of care are available to health services in Australia and overseas; what models of care for teleoncology are available to nursing services; what models of care for teleoncology are available to allied health services; is teleoncology as effective as standard oncology care for the screening of cancer; is teleoncology as effective as standard oncology care for the diagnosis of cancer; is teleoncology as effective as standard oncology care for the treatment of cancer; and is teleoncology as effective as standard oncology care for the palliative care of cancer patients.

Neuroendocrine Tumors – Version 2.2016

Year: 2016
AGREE II score: Unavailable
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for the screening, diagnosis, staging, and treatment of neuroendocrine tumors. This guideline provides recommendations on issues including: multiple endocrine neoplasia, surveillance of resected neuroendocrine tumors of the gastrointestinal tract, lung, and thymus, and genetic counseling/testing in pheochromocytomas/paragangliomas. Most of the guideline sections pertain to well-differentiated, low- to intermediate-grade tumors, although poorly differentiated/high-grade/large or small cell carcinomas are also addressed.

Systemic Light Chain Amyloidosis – Version 1.2016

Year: 2016
AGREE II score: Unavailable
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for the diagnosis and management of systemic light chain amyloidosis. Primary systemic light chain amyloidosis is typically characterized by decreased numbers of monoclonal plasma cells in the bone marrow compared to multiple myeloma, however, the protein produced by these plasma cells has an affinity for visceral organs (such as kidney, heart, liver, and spleen), and this protein causes related end-organ dysfunction. Recommendations include a discussion of the management options such as transplant and chemotherapy.

Kidney Cancer – Version 1.2017

Year: 2016
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with renal cell carcinoma (RCC). The guideline provides recommendations for the initial evaluation and staging, treatment, and follow-up for adults with various stages of kidney cancer. Topic areas discussed in the guideline include: imaging, surgery, lymph node dissection, targeted therapy, and supportive care.

Bladder Cancer – Version 2.2016

Year: 2016
AGREE II score: Unavailable
Developer organization: National Comprehensive Cancer Network
This clinical practice guideline discusses evaluation, treatment (primary and secondary) options, and follow-up care for patients with bladder cancer. Specific workup and treatment recommendations are provided for non-muscle invasive disease, muscle invasive disease, upper genitourinary tract (GU) tumours, urothelial carcinomas of the prostate, and primary carcinoma of the urethra. Non-urothelial carcinomas of the bladder are also discussed.

Metastatic Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline

Year: 2016
AGREE II score: Available
Developer organization: American Society of Clinical Oncology
This is a clinical practice guideline for the treatment of patients with metastatic pancreatic cancer. This clinical practice guideline addresses six overarching clinical questions: After a histopathologic confirmation of pancreatic adenocarcinoma diagnosis, what initial assessment is recommended before initiating any therapy for metastatic pancreatic cancer? What is the appropriate first-line treatment of patients with metastatic pancreatic cancer? What is the appropriate therapy for patients with metastatic pancreatic cancer who experience either disease progression or intolerable toxicity with prior regimens for metastatic pancreatic cancer? When should the concept of palliative care be introduced? For patients with metastatic pancreatic cancer, what are the recommended strategies for relief of pain and symptoms? What is the recommended frequency of follow-up care/surveillance for patients with metastatic pancreatic cancer?

Clinical Standards for the Treatment of Rectal Cancer in Nova Scotia

Year: 2016
AGREE II score: Unavailable
Developer organization: Cancer Care Nova Scotia
This guideline discusses the clinical standards of care for the treatment of rectal cancer in Nova Scotia with all aspects of rectal cancer care covered, from diagnosis to survivorship and/or palliation. This includes recommended standards for professionals involved in care, pretreatment investigations, and surgical, neo-adjuvant, and adjuvant treatments. Other topics covered include lynch syndrome screening and referral to medical genetics. Psychosocial health services and supportive care recommendations are also reviewed.

Small Cell Lung Cancer – Version 2.2017

Year: 2016
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for small cell lung cancer and lung neuroendocrine tumours. Diagnosis, staging, prognostic factors, treatment and surveillance are reviewed. Treatment options include chemotherapy, with special topics of discussion including elderly patients and second- and third-line therapies, radiotherapy (thoracic radiotherapy, prophylactic cranial irradiation, and palliative radiotherapy), and surgery. Outcomes of interest include survival (disease free, overall, progression-free), response rates, and treatment toxicity.

Breast Cancer – Version 2.2016

Year: 2016
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This clinical practice guideline reviews workup, staging, and treatment for both noninvasive and invasive breast cancer. Special considerations include phyllodes tumor, Paget's disease, breast cancer during pregnancy, and inflammatory breast cancer. Treatment recommendations for invasive cancer are stratified by tumor receptor status and stage. Fertility and birth control is also discussed.

The Diagnosis, Treatment, and Follow-Up of Renal Cell Carcinoma

Year: 2016
AGREE II score: Unavailable
Developer organization: German Society of Hematology and Oncology (DGHO)
This is a clinical practice guideline for patients with renal cell carcinoma (RCC). The guideline discusses diagnosis, treatment, and follow-up, and provides specific recommendations on topics such as the primary treatment of RCC without metastases, systemic treatment for metastatic RCC, neoadjuvant/adjuvant therapy, as well as the resection and radiotherapy of metastases.

ECIL Guidelines for the Diagnosis of Pneumocystis Jirovecii Pneumonia in Patients With Haematological Malignancies and Stem Cell Transplant Recipients

Year: 2016
AGREE II score: Unavailable
Developer organization: European Conference on Infections in Leukemia (ECIL)
This is a clinical practice guideline for the diagnosis of Pneumocystis jirovecii pneumonia (PCP) in patients following treatment for hematological malignancies or after hematopoietic stem cell transplantation (HSCT). This guideline highlights the main differences in clinical presentation of PCP between hematology patients and other immunocompromised populations, especially HIV-infected patients, and the main risks factors including pre-existing respiratory disease, and genetic predisposition. The risk factors associated with specific therapies, such as corticosteroids, chemotherapeutic agents, and monoclonal antibodies are also addressed.

ACR Appropriateness Criteria Nasal Cavity and Paranasal Sinus Cancers 

Year: 2016
AGREE II score: Available
Developer organization: American College of Radiology
This guideline reviews clinical presentation and patient evaluation, prognostic factors, principles of management, and treatment outcomes for patients with nasal cavity and paranasal sinus cancers. Surgery, radiotherapy, and chemotherapy are discussed as treatment options. Special topics of interest include the management of cervical lymph nodes and the management of unusual pathologies of nasal cavity cancers, namely esthesioneuroblastoma and sinonasal undifferentiated carcinoma.

ACR Appropriateness Criteria Staging of Testicular Malignancy

Year: 2016
AGREE II score: Available
Developer organization: American College of Radiology
This is a clinical practice guideline for the staging of testicular malignancy. Recommendations are made with consideration of the following variant: staging testis tumour, diagnosed by orchiectomy. The guideline also discusses tumour markers and provides an overview of imaging modalities.

Consensus Recommendations for the Management of Chronic Lymphocytic Leukemia: Primary Care Guideline

Year: 2016
AGREE II score: Unavailable
Developer organization: Cancer Care Manitoba
A clinical practice guideline for patients with chronic lymphocytic leukemia (CLL), monoclonal B cell lymphocytosis (MBL) and small lymphocytic lymphoma (SLL). The guideline examines clinical assessment, staging, and treatment including supportive therapy and potential complications. Outcomes of interest include long-term remission, increases in secondary malignancies, and disease progression.

American Cancer Society Head and Neck Cancer Survivorship Care Guideline

Year: 2016
AGREE II score: Available
Developer organization: American Cancer Society
The American Cancer Society Head and Neck Cancer Survivorship Care Guideline was developed to assist primary care clinicians and other health practitioners with the care of head and neck cancer survivors, including monitoring for recurrence, screening for second primary cancers, assessment and management of long-term and late effects, health promotion, and care coordination. The guideline provides recommendations for management strategies for assisting patients with physical and psychosocial effects of head and neck cancer and its treatment.

Adjuvant Management of Early Stage Endometrial Cancer

Year: 2016
AGREE II score: Unavailable
Developer organization: American College of Radiology
A clinical practice guideline for patients with early stage endometrial cancer. The guideline examined adjuvant therapy, including brachytherapy, radiation, chemotherapy, as well as observation in patients with low-grade/low-risk endometrial adenocarcinoma. Outcomes of interest include recurrence, local control, and overall survival.

Penile Cancer – Version 2.2016

Year: 2016
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with squamous cell carcinoma (SCC) of the penis. The guideline reviews risk factors and clinical presentation, and provides recommendations for clinical staging, management of primary legions, management of regional lymph nodes, surveillance, and management of metastatic disease. Surgery, radiotherapy, and chemotherapy are reviewed as treatment options.

Ovarian Cancer: Including Fallopian Tube Cancer and Primary Peritoneal Cancer – Version 1.2016

Year: 2016
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with epithelial ovarian cancer including fallopian tube cancer and primary peritoneal cancer. Less common histopathologies including ovarian low malignant potential (LMP) tumor, malignant germ cell neoplasms, carcinosarcomas (malignant mixed Müllerian tumors [MMMTs] of the ovary), and malignant sex cord-stromal tumors, are also discussed. The guideline provides recommendations on diagnosis, treatment, follow-up, and relapse. Primary treatment options for ovarian cancer include surgery (risk-reducing or cytoreductive), chemotherapy (neoadjuvant and adjuvant), incomplete surgery and/or staging, anti-angiogenesis agents, and radiation therapy. The number of chemotherapy cycles and agents are reviewed, along with drug reactions.

Myelodysplastic Syndromes – Version 1.2017

Year: 2016
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for myelodysplastic syndromes (MDS). The guideline provides an update to recommendations on standard approaches to the diagnosis and treatment of MDS in both children and adults. The guideline discusses evaluation and prognostic stratification, Topics of interest include prognostic stratification, evaluation of related anemia and treatment of symptomatic anemia, and supportive care. Molecular abnormalities in MDS and comorbidity indices are also discussed.

Locally Advanced, Unresectable Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline

Year: 2016
AGREE II score: Available
Developer organization: American Society of Clinical Oncology
This clinical practice guideline provides evidence-based recommendations to oncologists and others for treatment of patients with locally advanced, unresectable pancreatic cancer (LAPC). The guideline addresses a number of key clinical questions including: what initial assessment is recommended before initiating therapy for LAPC; what is the appropriate initial treatment approach for people diagnosed with LAPC; and for people with LAPC, what are the recommended strategies for relief of pain and symptom burden.

Survivorship – Version 2.2016

Year: 2016
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
These clinical practice guidelines for survivorship provide screening, evaluation, and treatment recommendations for common consequences of cancer and cancer treatment to aid health care professionals who work with survivors of adult-onset cancer in the post-treatment period, including those in specialty cancer survivor clinics and primary care practices. The guidelines focus on the vast and persistent impact both the diagnosis and treatment of cancer can have on the adult survivor’s health, physical and mental states, health behaviors, professional and personal identity, sexuality, and financial standing.

Cervical Cancer – Version 1.2016

Year: 2016
AGREE II score: Unavailable
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with cervical cancer including squamous cell carcinoma, adenosquamous carcinoma, and adenocarcinoma of the cervix. The guideline discusses diagnosis and workup, principles of staging and surgery, primary treatment, adjuvant treatment, surveillance, and therapy for relapse. Special topics of consideration include incidental cervical cancer, radiation therapy, and cervical cancer and pregnancy.

Genital Tract Cancers in Females: Human Papillomavirus Related Cancers (Cervical, Vaginal & Vulvar)

Year: 2016
AGREE II score: Unavailable
Developer organization: BC Cancer Agency
This guideline outlines the screening, diagnosis, treatment, and follow-up of human papillomavirus related cancers. The guideline examines appropriate vaccination strategies, screening (including care controversies), and treatment including chemotherapy and surgical options. Outcomes of interest include fertility sparing and reduction of unnecessary Pap testing. Provincial resources are provided.

2016 EAU Guidelines on Urothelial Carcinomas of the Upper Urinary Tract

Year: 2016
AGREE II score: Available
Developer organization: European Association of Urology
This is a clinical practice guideline for patients with, or suspected of having, upper urinary tract urothelial carcinomas (UTUCs). The guideline reviews diagnostic assessment, staging, treatment, and follow-up. Treatment recommendations are provided based on whether the disease is localized or advanced and include radical nephroureterectomy, conservative surgery, adjuvant topical agents, chemotherapy, and radiotherapy. Outcomes of interest include risk factors, sensitivity and specificity of diagnostic tests, survival (recurrence-free, disease-free, and overall), disease progression, morbidity, and mortality.

Myeloma: Diagnosis and Management

Year: 2016
AGREE II score: Available
Developer organization: National Institute for Health and Care Excellence
This guideline is for adult patients over 16 years of age with suspected, newly diagnosed, or relapsed myeloma. The guideline provides recommendations on laboratory and imaging investigations, management of newly diagnosed myeloma, managing acute renal disease caused by myeloma, preventing and managing complications, disease monitoring, and managing relapsed myeloma. Recommendations are also provided on service organization. Outcomes of interest include time to biochemical and/or clinical progression, overall survival, adverse events, quality of life and resource use.

EAU – ESTRO – SIOG Guidelines on Prostate Cancer

Year: 2016
AGREE II score: Available
Developer organization: European Association of Urology
This is a clinical practice guideline for male patients diagnosed with or suspected of having prostate cancer. The guideline reviews classification and staging, diagnostic evaluation, disease management, and follow-up care. Side effects of local treatment and health-related quality of life in prostate cancer survivors are also discussed. Outcomes of interest include overall survival, cancer-specific survival, development of metastatic disease, sensitivity and specificity of diagnostic procedures, and side effects of treatment.

Guidelines for the Investigation and Management of Nodular Lymphocyte Predominant Hodgkin Lymphoma

Year: 2016
AGREE II score: Unavailable
Developer organization: British Society for Haematology
A clinical practice guideline for adult, adolescent, and child patients with nodular lymphocyte predominant Hodgkin lymphoma. The guideline examines investigation and management for multiple treatment stages, including disease transformations and fertility preservation options. Outcomes of interest include improved outcomes through combination chemotherapy, and improved end of treatment scans.

2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer

Year: 2016
AGREE II score: Available
Developer organization: American Thyroid Association
This is a clinical practice guideline for adult patients with thyroid nodules and differentiated thyroid cancer (DTC). The guideline provides recommendations on initial management of thyroid cancer including screening, staging, risk assessment, surgical management, radioiodine remnant ablation and therapy, and thyrotropin suppression therapy using levothyroxine, as well as long-term management including surveillance techniques, management of recurrent and metastatic disease, and consideration for clinical trials and targeted therapy. The evaluation and diagnostic approach for thyroid nodules is also discussed, including a review of indications for fine-needle aspiration biopsy and interpretation of results, as well as use of molecular markers and management of benign thyroid nodules. Outcomes of interest include survival, recurrence, sensitivity and specificity.

Thyroid Carcinoma – Version 1.2016

Year: 2016
AGREE II score: Unavailable
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for the diagnosis, staging, and treatment of thyroid carcinoma. Recommendations are stratified by histologic type, namely papillary, follicular, Hürthle cell, medullary, and anaplastic. Primary treatment options and assessment and management after initial treatment is reviewed. Recurrent or persistent disease is also discussed.

Pancreatic Adenocarcinoma – Version 2.2016

Year: 2016
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This clinical practice guideline reviews diagnosis and management of adenocarcinomas of the exocrine pancreas. Risk factors and genetic predisposition are discussed, and the guideline provides recommendations on screening, diagnosis and staging, and treatment options including systemic therapy, chemoradiation, and surgical management. Palliative and supportive care are also reviewed. Topics of interest include an overview of biomarkers, and suggestions for management of premalignant tumours of the pancreas.

Occult Primary (Cancer of Unknown Primary [CUP]) – Version 2.2017

Year: 2016
AGREE II score: Unavailable
Developer organization: National Comprehensive Cancer Network
This clinical practice guideline provides recommendations for evaluation, workup, management, and follow-up of 2 pathologic diagnoses in patients with epithelial occult primary cancer: adenocarcinoma or carcinoma not otherwise specified (NOS), and squamous cell carcinoma (SCC). Diagnostic tests are recommended based on disease location and patient gender. Treatment options for disseminated or localized disease for adenocarcinoma and site-specific SCC are also discussed.

Esophageal and Esophagogastric Junction Cancers – Version 2.2016

Year: 2016
AGREE II score: Unavailable
Developer organization: National Comprehensive Cancer Network
This clinical practice guideline provides recommendations on esophageal and esophagogastric junction (EGJ) cancers, including: a review of hereditary cancer predisposition syndromes associated with increased risk for esophageal and EGJ cancers, staging and pathology, imaging, and treatment including surgery, radiation therapy, combined modality therapy, chemotherapy, and targeted therapies. Surveillance, management of metastatic, or recurrent cancer, and best supportive care are also discussed. Special topics of interest include treatment and surveillance options for patients with Barrett's esophagus, and suggested strategies to help alleviate the current problems associated with leucovorin shortage.

Acute Lymphoblastic Leukemia – Version 2.2016

Year: 2016
AGREE II score: Unavailable
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients aged 15 or older with acute lymphoblastic leukemia (ALL). The guideline reviews diagnosis, workup and risk stratification, treatment and consolidation therapy stratified by age and Philadelphia chromosome presence/absence, surveillance, treatment for relapse/refractory disease, and supportive care. The guideline discusses typical immunophenotyping panels for all major subtypes, and minimal residual disease assessment. Evaluation and treatment of extra medullary involvement is also reviewed.

Neoadjuvant Chemotherapy for Newly Diagnosed, Advanced Ovarian Cancer: Society of Gynecologic Oncology and American Society of Clinical Oncology Clinical Practice Guideline

Year: 2016
AGREE II score: Available
Developer organization: American Society of Clinical Oncology
This is a clinical practice guideline for women with newly diagnosed or suspected stage IIIC or IV epithelial ovarian cancer, fallopian tub cancer, or primary peritoneal cancer. More specifically, the guideline provides guidance to clinicians and patients regarding the use of neoadjuvant chemotherapy (NACT) and interval cytoreduction. The guideline addresses a number of clinical questions including: what clinical evaluations should be performed in all women with suspected or newly diagnosed stage IIIC or IV epithelial ovarian cancer; what is the preferred chemotherapy regimen for women with stage IIIC or IV epithelial ovarian cancer who will receive NACT; and what are the treatment options for patients with progressive disease on NACT.

Potentially Curable Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline

Year: 2016
AGREE II score: Available
Developer organization: American Society of Clinical Oncology
This is a clinical practice guideline provides evidence-based recommendations to oncologists and others on potentially curative therapy for patients with localized pancreatic cancer. Key recommendations are guided by questions including: what initial assessment is recommended before initiating any therapy for potentially curable pancreatic cancer; what is the appropriate adjuvant regimen for patients with pancreatic cancer who have undergone a resection of their primary tumor; and when should palliative care services be initiated for people with pancreatic cancer that is potentially curable by surgery.

Esophageal Cancer

Year: 2016
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients over 18 years of age with esophageal cancer, including both squamous cell and adenocarcinoma. The guideline provides recommendations on diagnostic work-up, staging, treatment options for potentially curable cancer stratified by stage, and management options for incurable cancer. Esophagectomy, endoscopic therapy, primary chemoradiotherapy, radiotherapy, pre-operative chemoradiotherapy followed by esophagectomy and pre-operative chemotherapy are discussed, as well as supportive care. Outcomes of interest include survival (overall, progression-free, 5-year), morbidity, toxicity, and rate of sudden death.

ESPEN Guidelines on Nutrition in Cancer Patients

Year: 2016
AGREE II score: Available
Developer organization: European Society for Clinical Nutrition and Metabolism
This is a clinical practice guideline for the identification, prevention, and treatment of reversible elements of malnutrition in adult cancer patients. The specific objectives of this guideline are to improve early detection and treatment of malnutrition and metabolic derangements in cancer patients and cancer survivors; to provide guidance to health care workers and patients on the most appropriate and effective management of nutritional and metabolic problems in cancer patients; and, by this, to lower the incidence and impact of malnutrition and metabolic derangements in cancer patients and survivors. Topics considered include: effects of nutritional intervention during cytostatic and targeted therapies on treatment tolerance, response to treatment and overall survival, as well as effect of artificial nutrition on treatment tolerance, treatment completion, relapse rate and overall survival.

Clinical Practice Guidelines for the Diagnosis and Management of Melanoma

Year: 2016
AGREE II score: Available
Developer organization: Cancer Council Australia
This is a clinical practice guideline for the diagnosis and management of melanoma. The purpose of these guidelines is to achieve early diagnosis whenever possible, make doctors and patients aware of the most effective treatment options, and minimize the financial burden on the health system by documenting investigations and therapies that are inappropriate. Topics discussed include: features of melanoma, biopsy, sentinel node biopsy, and excision margins.

American Association Of Clinical Endocrinologists, American College Of Endocrinology, and Associazione Medici Endocrinologi Medical Guidelines for Clinical Practice for the Diagnosis and Management Of Thyroid Nodules – 2016 Update

Year: 2016
AGREE II score: Unavailable
Developer organization: American Association of Clinical Endocrinologists
This guideline addresses diagnostic and therapeutic aspects of thyroid nodular disease; thyroid cancer management is not addressed. The guideline provides recommendations on clinical evaluation and diagnosis, thyroid ultrasonography and other imaging studies, thyroid biopsy, laboratory evaluation, radionuclide scanning, and management and therapy of nodules. Special topics of consideration are thyroid nodules during pregnancy and management of thyroid nodules in children.

Haematological Cancers: Improving Outcomes

Year: 2016
AGREE II score: Available
Developer organization: National Institutes of Health
This guideline covers integrated diagnostic reporting for diagnosing hematological cancer in adults, young people and children. It also covers staffing, facilities (levels of care) and multidisciplinary teams needed for adults and young people. It aims to improve care for people with suspected or diagnosed cancer by promoting best practice on the organization of hematological cancer services.

Guidelines for the Management of Diffuse Large B-cell Lymphoma

Year: 2016
AGREE II score: Unavailable
Developer organization: British Committee for Standards in Haematology
This is a clinical practice guideline for the management of diffuse large B-cell lymphoma. Recommendations include consideration of: prognostic factors, early stage disease, advanced stage disease, relapsed/refractory disease in the transplant-eligible patient, HIV-associated DLBCL, management of the elderly, frail or unfit patient with DLBCL, and follow-up.

ACR Appropriateness Criteria Palpable Breast Mass

Year: 2016
AGREE II score: Available
Developer organization: American College of Radiology
A clinical practice guideline for patients with palpable breast masses. The guideline examines imaging modalities, including mammography, digital breast tomosynthesis, and ultrasound, based on clinical variants. Outcomes of interest include sensitivity and accuracy.

Lymphoma

Year: 2016
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline addressing lymphoma in the adult population. The guideline focuses on diagnosis and pathology, staging, and treatment of Non-Hodgkin Lymphomas, Hodgkin Lymphoma, HDCT and hematopoietic stem cell transplantation for lymphoma. Supportive and follow-up care is also addressed. The guideline updates the 2015 guideline of the same title.

Acute Lymphoblastic Leukemia

Year: 2016
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for the diagnosis and treatment of acute lymphoblastic leukemia in adult and pediatric patients. The guideline examines diagnostic methods, treatment by age group, and special considerations including allogeneic stem cell transplantation and the role of cranial radiation. Outcomes of interest include probability of survival and incidence of hematological relapse.

Uterine Neoplasms – Version 1.2017

Year: 2016
AGREE II score: Unavailable
Developer organization: National Comprehensive Cancer Network
A clinical practice guideline for patients with suspected uterine neoplasms. The guideline examines surveillance, diagnostic assessment, and treatment focusing primarily on surgical interventions and systemic therapy. Outcomes of interest include long-term survival and reproductive sparing.

Thymomas and Thymic Carcinomas – Version 3.2016

Year: 2016
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for the evaluation, treatment, and management of thymomas and thymic carcinomas. The guideline considers surgical resection, systemic therapies, and radiation therapies for both mediastinal and thymic masses.

Adolescent and Young Adult (AYA) Oncology – Version 1.2017

Year: 2016
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This clinical practice guideline is for adolescents and young adults (AYAs), defined as individuals aged 15 to 39 years, who have been diagnosed with cancer. The guideline discusses issues specific to AYAs and recommends interventions unique to these patients. Topics include an overview of risk factors, screening, diagnosis, and special considerations for management of AYA patients such as adherence to treatment and fertility preservation, contraception for women during and after cancer treatment, and management of cancer during pregnancy. Psychosocial and behavioural issues, survivorship issues, and palliative and end-of-life care are also discussed.

Evidence-Based Recommendations for the Management of Potentially Curable Esophageal Carcinoma

Year: 2015
AGREE II score: Unavailable
Developer organization: Cancer Care Manitoba
A clinical practice guideline for adult patients with potentially curable esophageal carcinoma. The guideline examines diagnosis with FDG-PET/CT, staging, and treatment options including chemoradiotherapy and brachytherapy. Outcomes of interest include staging accuracy and treatment response.

Provincial Consensus Recommendations on the Evaluation, Diagnosis and Management of a Suspicious Lateral Neck Mass

Year: 2015
AGREE II score: Available
Developer organization: Cancer Care Manitoba
This is a clinical practice guideline for the evaluation, diagnosis and management of a suspicious lateral neck mass in adults. Use of history and physical exam, X-ray, CT scan, and fine needle aspiration biopsy (FNAB) are discussed along with urgency of referral depending on results. Additionally, the guideline addresses the diagnosis or suspicion of lymphoma, as well as appropriate use of open biopsy.

The Role of Endoscopy in the Diagnosis and Treatment of Cystic Pancreatic Neoplasms

Year: 2015
AGREE II score: Unavailable
Developer organization: American Society for Gastrointestinal Endoscopy
This is a clinical practice guideline for the use of GI endoscopy in the evaluation and treatment of pancreatic neoplasms. Diagnosis by endoscopic ultrasound (EUS) is discussed, as is use of EUS-guided-fine needle aspiration (FNA) to determine cytology, chemistries and tumour markers such as CEA, as well as cyst fluid DNA and molecular analysis. Other topics of discussion include emerging techniques for cyst evaluation, adverse events fro EUS, diagnosis by ERCP (Endoscopic Retrograde Cholangio-Pancreatography), and endoscopic treatment of cystic lesions.

The Role of Neuropathology in the Management of Patients with Diffuse Low Grade Glioma: A Systematic Review and Evidence-Based Clinical Practice Guideline

Year: 2015
AGREE II score: Available
Developer organization: American Association of Neurological Surgeons/ Congress of Neurological Surgeons
This is a clinical practice guideline for the diagnosis and management of patients with diffuse low grade glioma. More specifically, the guideline addresses a number of questions related to the diagnosis and management of patients with diffuse low grade glioma including: what are the optimal neuropathological techniques to diagnose low-grade glioma in the adult; and, in adult patients with histologically-proven WHO grade II diffuse glioma, is MGMT promoter methylation testing warranted? If so, is there a preferred method? In addition to providing recommendations in response to questions like those stated above, the guideline also identifies key issues for future investigation such as the identification of distinct molecular characteristics.

2015 EAU Guidelines on Renal Cell Carcinoma (Update March 2015)

Year: 2015
AGREE II score: Available
Developer organization: European Association of Urology
This is a clinical practice guideline for the management of renal cell carcinoma. The guideline examines the diagnosis, staging, treatment, and follow-up of renal cell carcinoma, with treatment recommendations stratified by disease stage. Therapeutic strategies are also discussed. Outcomes of interest include overall survival, cancer-specific survival, recurrence-free survival, and quality of life.

2015 EAU Guidelines on Urothelial Carcinomas of the Upper Urinary Tract (Limited Update March 2015)

Year: 2015
AGREE II score: Unavailable
Developer organization: European Association of Urology
This clinical practice guideline provides recommendations for urothelial carcinomas of the upper urinary tract. The guideline covers epidemiology, etiology, and pathology, staging, diagnosis, prognosis, disease management, and follow-up. Issues addressed in the guideline include: risk factors, symptoms, imaging, preoperative factors, predictive tools, and management for both localized and advanced disease.

Diagnosis and Treatment of Primary CNS Lymphoma in Immunocompetent Patients: Guidelines From the European Association for Neuro-Oncology

Year: 2015
AGREE II score: Unavailable
Developer organization: European Association for Neuro-Oncology
This is a clinical practice guideline for immunocompetent adults with primary CNS lymphoma. The guideline provides consensus considerations and recommendations for diagnosis, assessment, staging, and treatment of primary CNS lymphoma. Specifically, the guideline addresses aspects of care related to surgery, systemic and intrathecal chemotherapy, intensive chemotherapy with autologous stem-cell transplantation, radiotherapy, intraocular manifestations, and management of elderly patients.

Provincial Oropharyngeal Cancer Treatment Guidelines

Year: 2015
AGREE II score: Unavailable
Developer organization: Saskatchewan Cancer Agency
This is a clinical practice guideline for the diagnosis, staging, and treatment of oropharyngeal cancer. The guidelines provide recommendations on staging for primary tumour, regional lymph nodes, and distant metastases; management of invasive carcinoma of oropharynx, locally advanced resectable disease; post-operative adjuvant therapy options, post chemoradiation or post radiation evaluation; salvage therapy; radiation therapy; concurrent chemotherapy; and management of residual disease, loco-regional recurrent or distant metastases.

Provincial Nasopharyngeal Cancer Treatment Guidelines

Year: 2015
AGREE II score: Unavailable
Developer organization: Saskatchewan Cancer Agency
This is a clinical practice guideline for the assessment and management of patients with nasopharyngeal carcinoma. The guideline explores the etiology of nasopharyngeal carcinoma as well as the pathologic classification and staging. Recommendations are provided for assessment and include discussions of imaging and specimen collection. Additionally, the guideline explores appropriate management options and provides guidance on how to proceed in cases of suspected recurrent disease.

Oropharyngeal, Hypopharyngeal and Laryngeal Cancer: Diagnosis, Treatment and Follow-Up

Year: 2015
AGREE II score: Available
Developer organization: Belgian Health Care Knowledge Centre
A clinical practice guideline for the diagnosis, treatment, and follow-up of oropharyngeal, hypopharyngeal and laryngeal cancers. The guideline examines preferred locoregional staging methods and treatment options including an emphasis on interprofessional care. Outcomes of interest include limited evidence for the benefits of surgical treatment in some cases and some evidence that primary chemotherapy may provide some benefit over radiotherapy.

Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer

Year: 2015
AGREE II score: Unavailable
Developer organization: American Thyroid Association
These inaugural guidelines provide recommendations for the evaluation and management of thyroid nodules in children and adolescents, including the role and interpretation of ultrasound, fine-needle aspiration cytology, and the management of benign nodules. Recommendations for the evaluation, treatment, and follow-up of children and adolescents with differentiated thyroid cancer (DTC) are outlined and include preoperative staging, surgical management, postoperative staging, the role of radioactive iodine therapy, and goals for thyrotropin suppression. Management algorithms are proposed and separate recommendations for papillary and follicular thyroid cancers are provided.

Management of Cervical Cancer (Second Edition)

Year: 2015
AGREE II score: Available
Developer organization: Ministry of Health Malaysia
A clinical practice guideline for the management of female patients with cervical cancer. The guideline examines diagnosis, staging, treatment including surgery and adjuvant therapy, and follow up. Outcomes of interest include fertility preservations and improved quality of life through hormonal replacement therapy during follow up.

Renal Cancer in Adults: Diagnosis, Treatment and Follow-up

Year: 2015
AGREE II score: Available
Developer organization: Belgian Health Care Knowledge Centre
A clinical practice guideline for adult patients with renal cancer. The guideline examines treatment through surgery and ablative therapy, diagnosis, and follow-up. Outcomes of interest include improved prediction of cancer-specific survival through Karakiewicz nomograms and improved evidence for microwave ablation.

Genital Tract Cancers in Females: Human Papillomavirus Related Cancers (Cervical, Vaginal & Vulvar)

Year: 2015
AGREE II score: Unavailable
Developer organization: BC Cancer Agency
This guideline outlines the screening, diagnosis, treatment, and follow-up of human papillomavirus related cancers. The guideline examines appropriate vaccination strategies, screening (including care controversies), and treatment including chemotherapy and surgical options. Outcomes of interest include fertility sparing and reduction of unnecessary Pap testing.

Cancer-Related Fatigue, Version 2.2015

Year: 2015
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients (children/adolescents and adults) who are experiencing cancer-related fatigue. The guideline discusses evaluation and intervention for patients on active treatment, post-treatment, and at end of life. Education and counselling, nonpharmacologic interventions, and pharmacologic interventions are all discussed along with general strategies for management of fatigue.

Pancreatic Adenocarcinoma, Version 2.2015

Year: 2015
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This clinical practice guideline reviews diagnosis and management of adenocarcinomas of the exocrine pancreas. Risk factors and genetic predisposition are discussed, and the guideline provides recommendations on screening, diagnosis and staging, and treatment options including systemic therapy, chemoradiation, and surgical management. Palliative and supportive care are also reviewed. Topics of interest include an overview of biomarkers, and suggestions for management of premalignant tumours of the pancreas.

Occult Primary (Cancer of Unknown Primary [CUP]), Version 1.2015

Year: 2015
AGREE II score: Unavailable
Developer organization: National Comprehensive Cancer Network
This clinical practice guideline provides recommendations for evaluation, workup, management, and follow-up of 2 pathologic diagnoses in patients with epithelial occult primary cancer: adenocarcinoma or carcinoma not otherwise specified (NOS), and squamous cell carcinoma (SCC). Diagnostic tests are recommended based on disease location and patient gender. Treatment options for disseminated or localized disease for adenocarcinoma and site-specific SCC are also discussed.

Multiple Myeloma, Version 2.2016

Year: 2015
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for multiple myeloma. The guideline addresses diagnosis, treatment, and follow-up for patients with multiple myeloma. It offers specific recommendations for primary therapy, surveillance and follow-up tests for solitary plasmacytoma, smoldering (asymptomatic) myeloma, active (symptomatic) multiple myeloma, as well as for transplant and non-transplant candidates.

Melanoma: Assessment and Management

Year: 2015
AGREE II score: Available
Developer organization: National Institute for Health and Care Excellence
This clinical practice guideline is for patients diagnosed with or suspected of having melanoma. The guideline provides recommendations on diagnostic assessment, staging, and management. Follow-up care is also discussed, including topics such as management of suboptimal Vitamin D levels and concurrent drug therapies. Outcomes of interest include survival (overall, disease free, melanoma specific), and adverse events (acute toxicity, wound/sensory complications).

Prostate Cancer

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This clinical practice guideline provides recommendations on management of prostate cancer, including diagnosis and screening, management stratified by risk, and follow up care. Active surveillance, surgery (radical prostatectomy), external beam radiotherapy (EBRT), low dose rate (LDR) brachytherapy, cryosurgery, High Intensity Focused Ultrasound (HIFU), Androgen Deprivation Therapy (ADT), and systemic therapies are discussed as treatment options. Bone health is also reviewed. Outcomes of interest include survival and recurrence.

EASL-ALEH Clinical Practice Guidelines: Non-Invasive Tests for Evaluation of Liver Disease Severity and Prognosis

Year: 2015
AGREE II score: Unavailable
Developer organization: European Association for the Study of the Liver
This is a clinical practice guideline for the evaluation of liver disease severity and prognosis. The guideline considers the value of liver biopsy for fibrosis evaluation and compares it to other non-invasive tests. The guideline developers considered a number of different questions including: what are the currently available non-invasive tests; how do serum biomarkers perform for staging liver fibrosis; and what are the indications for non-invasive tests for staging liver disease in viral hepatitis.

European Myeloma Network Guidelines for the Management of Multiple Myeloma-Related Complications

Year: 2015
AGREE II score: Unavailable
Developer organization: European Myeloma Network
A clinical practice guideline for the management of complications in patients with multiple myeloma. The guideline examines treatment and supportive care for common complications, including pain management, anemia, renal impairment, peripheral neuropathy, infections, and venous thromboembolisms. Outcomes of interest include renal failure, fracture, and reduced impairment.

American Gastroenterological Association Institute Guideline on the Diagnosis and Management of Lynch Syndrome

Year: 2015
AGREE II score: Available
Developer organization: American Gastroenterological Association
This clinical practice guideline provides recommendations on the diagnosis of Lynch syndrome in patients without a personal history of colorectal or another cancer but with a family history suggestive of Lynch syndrome, as well as for patients with colorectal cancer with IHC absent for MLH1. Management of the risk of colorectal cancer for patients with Lynch syndrome is also discussed with a review of surveillance colonoscopy and recommendations on the use of aspirin as a preventative measure for cancer. Outcomes of interest include sensitivity, specificity, false-positive and false-negative rates of diagnostic tests, as well as psychological distress/quality of life, colorectal cancer incidence, staging, and mortality, Lynch-syndrome associated cancer incidence and mortality, surgical complications from colonoscopy, and costs.

Executive Summary of the SEPAR Recommendations for the Diagnosis and Treatment of Non-Small Cell Lung Cancer

Year: 2015
AGREE II score: Unavailable
Developer organization: Spanish Society of Pulmonology and Thoracic Surgery
This is a clinical practice guideline fore patients who have been diagnosed with or are at risk of developing non-small cell lung cancer (NSCLC). The guideline provides recommendations on disease prevention and screening, including risk factors, the role of smoking cessation, and screening programs for early diagnosis. Recommendations regarding clinical presentation are also presented, with specific topics such as imaging studies, and surgical risk, including cardiological risk and the evaluation of respiratory function. The guideline also provides guidance on follow-up, when appropriate.

Guideline for the Management of Bile Duct Cancer by the Brazilian Gastrointestinal Tumor Group

Year: 2015
AGREE II score: Unavailable
Developer organization: Brazilian Gastrointestinal Tumor Group
This is a clinical practice guideline for patients with biliary tract cancers, including gallbladder cancer, intrahepatic and extrahepatic cholangiocarcinoma, and cancer of the duodenal papilla. The guideline examines the diagnosis, staging, and treatment of these patients. Tests discussed for the diagnosis and staging include endoscopic retrograde cholangiopancreatography (ERCP), upper GI endoscopy (UGIE), endoscopic ultrasound (EUS), cholangioscopy, and laparoscopy. Surgical options are stratified by disease type, and both adjuvant treatment and systemic treatment for metastatic cancer of the biliary tract are also discussed.

Guidelines on the Management and Admission to Intensive Care of Critically Ill Adult Patients With Haematological Malignancy in the UK

Year: 2015
AGREE II score: Unavailable
Developer organization: British Society of Haematology (BSH)
This is a clinical practice guideline on the management and admission to intensive care of critically ill adult patients with hematological malignancy. This guideline is intended to be of use to hematologists and intensivists practicing in the UK, and outlines some of the major considerations in the management of the critically ill patient with hematological malignancy.

2015 EAU Guidelines on Primary Urethral Carcinoma (Limited Update 2015)

Year: 2015
AGREE II score: Unavailable
Developer organization: European Association of Urology
This is a clinical practice guideline for patients with, or suspected of having, primary urethral carcinoma. The guideline reviews diagnostic assessment, staging, and treatment. Treatment options include penile-preserving and urethral-sparing surgery, urethrectomy, radiotherapy, cisplatinum-based chemotherapy, chemoradiotherapy, transurethral resection (TUR), Bacille-Calmette-Guérin (BCG), and cystoprostatectomy with extended pelvic lymphadenectomy. Outcomes of interest include survival, sensitivity of diagnostic tests, local cure rate, local recurrence rate, and local tumour control rate.

Multiparametric Magnetic Resonance Imaging in the Diagnosis of Clinically Significant Prostate Cancer

Year: 2015
AGREE II score: Available
Developer organization: Cancer Care Ontario
A clinical practice guideline for the diagnostic assessment of clinically significant prostate cancer. The guideline examines Multiparametric magnetic resonance imaging as an alternative to traditional transrectal ultrasound–guided systematic biopsy in order to reduce over- or under-diagnosis of clinical results. Outcomes of interest include detection rate of clinically significant prostate cancer, improved survival, and improved predictive value.

The Organization of Colposcopy Services in Ontario: Recommended Framework

Year: 2015
AGREE II score: Unavailable
Developer organization: Cancer Care Ontario
An organizational guideline for the provision of colonoscopies to patients with abnormal cervical screening results. The guideline examines the provision of consistent quality in colonoscopies, including training and competence, practices, and quality indicators. Important aspects include training program availability, referral criteria, and group vs. individual practice requirements.

2014 KLCSG-NCC Korea Practice Guideline for the Management of Hepatocellular Carcinoma

Year: 2015
AGREE II score: Available
Developer organization: Korean Liver Cancer Study Group (KLCSG)
This clinical practice guideline provides recommendations on prevention, diagnosis, and treatment of hepatocellular carcinoma. Treatment options are discussed including surgical resection, transplantation, local ablation, transarterial chemoembolization, external-beam radiation therapy, systemic therapies, preemptive antiviral therapy, and drug treatment for cancer pain. Assessment of tumour response and post-treatment follow-up are also reviewed.

Provincial Non-Small Cell Lung Cancer Treatment Guidelines

Year: 2015
AGREE II score: Unavailable
Developer organization: Saskatchewan Cancer Agency
A clinical practice guideline for the management of patients with non-small cell lung cancer. The guideline examines screening for at-risk populations, diagnostic work-up, treatment, and follow-up. Outcomes of interest include clarified current standard of care through lobectomy and mediastina lymph node dissection, with additional treatment selections based on patient population.

CUA Guidelines on the Management of Non-Muscle Invasive Bladder Cancer

Year: 2015
AGREE II score: Unavailable
Developer organization: Canadian Urological Association
A clinical practice guideline for patients with non-muscle invasive bladder cancer. The guideline examines management, emphasizing intravesical therapy and prognostic factors. Outcomes of interest include lower recurrence and longer disease-free intervals with transurethral resection of bladder tumours.

Multiple Myeloma

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is an update to the 2013 clinical practice guideline for the management of multiple myeloma in adult patients. The guideline examines diagnosis and treatment for multiple myeloma, monoclonal gammopathy, smoldering myeloma, and amyloidosis, including prognostic criteria. Outcomes of interest include improved survival outcomes through triple drug based induction regimens and improved dose reduction options for elderly patients.

Lymphoma

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline addressing lymphoma in the adult population. The guideline focuses on the following areas: Diagnosis and Pathologic Classification, Staging, Treatment of Non-Hodgkin Lymphomas, Hodgkin Lymphoma, HDCT and hematopoietic stem cell transplantation for lymphoma, supportive care in the treatment of lymphoma, and follow-up care in the treatment of lymphoma. Additionally, it seeks to provide recommendations to the following questions: what are the diagnostic criteria for the most common lymphomas; what are the staging and re-staging procedures for Hodgkin and non-Hodgkin lymphomas; what are the recommended treatment and management options for Hodgkin and non-Hodgkin lymphomas; and what are the recommended follow-up procedures for patients with malignant Hodgkin and non-Hodgkin lymphoma.

Older Adult Oncology, Version 2.2015

Year: 2015
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This clinical practice guideline discusses specific issues related to the management of cancer in adults aged 65 years or older. Topics include screening and comprehensive geriatric assessment (CGA), assessing risks and benefits of treatment, preventing or decreasing complications from therapy, and managing disease-specific issues. Recommendations are also provided for management of patients deemed to be at high risk for toxicity from standard treatment.

Adolescent and Young Adult (AYA) Oncology, Version 1.2016

Year: 2015
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This clinical practice guideline is for adolescents and young adults (AYAs), defined as individuals aged 15 to 39 years, who have been diagnosed with cancer. The guideline discusses issues specific to AYAs and recommends interventions unique to these patients. Topics include an overview of risk factors, screening, diagnosis, and special considerations for management of AYA patients such as adherence to treatment and fertility preservation, contraception for women during and after cancer treatment, and management of cancer during pregnancy. Psychosocial and behavioural issues, survivorship issues, and palliative and end-of-life care are also discussed.

Small Cell Lung Cancer, Version 1.2016

Year: 2015
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for small cell lung cancer and lung neuroendocrine tumours. Diagnosis, staging, prognostic factors, treatment and surveillance are reviewed. Treatment options include chemotherapy, with special topics of discussion including elderly patients and second-line and third-line therapies, radiotherapy (thoracic radiotherapy, prophylactic cranial irradiation, and palliative radiotherapy), and surgery. Outcomes of interest include survival (disease free, overall, progression-free) and response rates, and treatment toxicity.

Ovarian Cancer: Including Fallopian Tube Cancer and Primary Peritoneal Cancer, Version 2.2015

Year: 2015
AGREE II score: Unavailable
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with epithelial ovarian cancer including fallopian tube cancer and primary peritoneal cancer. Less common histopathologies including ovarian low malignant potential (LMP) tumour, malignant germ cell neoplasms, carcinosarcomas (malignant mixed Müllerian tumours [MMMTs] of the ovary), and malignant sex cord-stromal tumours, are also discussed. The guideline provides recommendations on diagnosis, treatment, follow-up, and relapse. Primary treatment options for ovarian cancer include surgery (risk-reducing or cytoreductive), chemotherapy (neoadjuvant and adjuvant), incomplete surgery and/or staging, anti-angiogenesis agents, and radiation therapy. The number of chemotherapy cycles and agents are reviewed, along with drug reactions.

Dermatofibrosarcoma Protuberans, Version 1.2016

Year: 2015
AGREE II score: Unavailable
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for dermatofibrosarcoma protuberans (DFSP). The NCCN Non-Melanoma Skin Cancer Panel has developed these guidelines outlining the treatment of DFSP to supplement their guidelines for basal cell and squamous cell skin cancers and merkel cell carcinoma. Topic areas discussed in this guideline as they relate to DFSP include: biopsy, surgery, chemotherapy, and radiotherapy.

Waldenström’s Macroglobulinemia / Lymphoplasmacytic Lymphoma, Version 2.2016

Year: 2015
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for Waldenström's Macroglobulinemia (WM) / Lymphoplasmacytic Lymphoma (LPL). The guideline provides recommendations for the diagnosis, work up, and treatment of WM / LPL. Topic areas discussed in the guideline include: primary treatment regimens (both regimens not toxic to stems cells as well as regimens with potential or unknown toxicity to stem cells), assessment of response to treatment, follow-up after primary treatment, treatment of IgM-related peripheral neuropathy, maintenance therapy, and management of patients who are intolerant to rituximab.

Rectal Cancer, Version 1.2016

Year: 2015
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with colon cancer. The guideline reviews risk assessment, TNM staging, and pathology, and provides recommendations on the clinical presentation and treatment of nonmetastatic disease as well as recommendations on management of metastatic disease. Treatment for locally recurrent disease and survivorship are also discussed, as is the role of vitamin D in colorectal cancer.

Bladder Cancer, Version 2.2015

Year: 2015
AGREE II score: Unavailable
Developer organization: National Comprehensive Cancer Network
This clinical practice guideline discusses evaluation, treatment (primary and secondary) options, and follow-up care for patients with bladder cancer. Specific workup and treatment recommendations are provided for non-muscle invasive disease, muscle invasive disease, upper genitourinary tract (GU) tumours, urothelial carcinomas of the prostate, primary carcinoma of the urethra. Non-urothelial carcinomas of the bladder are also discussed.

Acute Myeloid Leukemia, Version 1.2015

Year: 2015
AGREE II score: Unavailable
Developer organization: National Comprehensive Cancer Network
This clinical practice guideline provides recommendations for the diagnosis and treatment of acute myeloid leukemia (AML). Induction therapy and post-remission (consolidation) therapy are reviewed with recommendations stratified by risk and age. Specific recommendations are provided for the management of acute promyelocytic leukemia (APL). The guideline also discusses therapy for relapse, evaluation and treatment of CNS leukemia, and supportive care.

Bladder Cancer: Diagnosis and Management

Year: 2015
AGREE II score: Available
Developer organization: National Institute for Health and Care Excellence
This is a clinical practice guideline for adults age 18 years and older who are suspected of having or are newly diagnosed with bladder cancer or cancer of the urethra, or diagnosed with recurring bladder cancer or cancer of the urethra. The guideline provides recommendations on diagnosis, staging, and management of muscle-invasive, non-muscle invasive, locally advanced, and metastatic bladder cancers. Management of treatment side effects and follow-up care is also discussed. Outcomes of interest include survival (overall, disease-free), disease-related morbidity and mortality, treatment-related morbidity and mortality, psychological well-being, quality of life, admissions to hospital after diagnosis, adverse events, and cost-effectiveness.

BTS Guidelines for the Investigation and Management of Pulmonary Nodules

Year: 2015
AGREE II score: Unavailable
Developer organization: British Thoracic Society
This is a clinical practice guideline for the investigation and management of pulmonary nodules. The guideline highlights new research evidence which has led to significant changes in recommendations for the management of pulmonary nodules. The guideline provides clarity in the use of imaging as well as clarity about the place of biopsy in the investigation and management of pulmonary nodules.

Early Rectal Cancer: The European Association for Endoscopic Surgery (EAES) Clinical Consensus Conference

Year: 2015
AGREE II score: Available
Developer organization: European Association for Endoscopic Surgery
This is a clinical practice guideline for patients with early rectal cancer. The guideline provides recommendations on diagnosis, staging, and treatment. Local excision, rectal resection, and total mesorectal excision are discussed as surgical options, and laparoscopic and open approaches to abdominal surgery are compared. The use of neoadjuvant (chemo) radiation therapy is also discussed. Outcomes of interest include diagnostic accuracy, sensitivity, and specificity of diagnostic and staging procedures, local recurrence, survival (5-year, overall, disease free), distant metastases rate, morbidity, and quality of life.

Recommendations for Post-Surgical Thyroid Ablation in Differentiated Thyroid Cancer: A 2015 Position Statement of the Italian Society Of Endocrinology

Year: 2015
AGREE II score: Unavailable
Developer organization: Italian Society of Endocrinology
This is a clinical practice guideline for patients with thyroid cancer. The guideline examines the post-surgical ablation of thyroid remnant with radioactive iodine (RAI) in these patients. Preparation for RAI ablation, diagnostic RAI scanning before ablation, post-operative serum thyroglobulin (Tg) levels and neck ultrasound (US), and post-therapy whole-body scan (WBS) after remnant ablation are discussed.

Management of Cutaneous Squamous Cell Carcinoma in Patients With Epidermolysis Bullosa: Best Clinical Practice Guidelines

Year: 2015
AGREE II score: Unavailable
Developer organization: British Association of Dermatologists
This is a clinical practice guideline for patients with epidermolysis bullosa. The guideline provides recommendations for the diagnosis, staging, and management of cutaneous squamous cell carcinoma (SCC) in these patients. Specific topics discussed include surveillance and diagnosis, tumour evaluation and staging, surgical treatment, nonsurgical treatment, the use of prosthetics, and end-of-life care.

Clinical Practice Guidelines for the Diagnosis and Treatment of Patients With Soft Tissue Sarcoma by the Spanish Group for Research in Sarcomas (GEIS)

Year: 2015
AGREE II score: Unavailable
Developer organization: Spanish Group for Research on Sarcoma
This is a clinical practice guideline for patients with soft tissue sarcoma (STS). The guideline examines the diagnosis and treatment of these patients. Diagnostic techniques discussed include local staging, distant staging, biopsy, and pathology and molecular pathology. Treatment methods discussed include surgery, radiotherapy, adjuvant chemotherapy, neoadjuvant chemotherapy, isolated limb perfusion, as well as chemotherapy and targeted agents. Therapeutic considerations for specific STS subtypes are also examined.

Provincial Unknown Primary of Head and Neck Cancer Treatment Guidelines

Year: 2015
AGREE II score: Unavailable
Developer organization: Saskatchewan Cancer Agency
This is a clinical practice guideline for the treatment of unknown primary head and neck cancer. An unknown or 'occult' primary is one where a primary tumour cannot be identified after appropriate investigation, in a patient with no prior history of head and neck cancer. The guideline provides recommendations on the initial workup of all patients with a neck mass, as well as recommendations for staging, management, and cases of recurrent disease.

Role of Cytotoxic Therapy With Hematopoietic Cell Transplantation in the Treatment of Hodgkin Lymphoma: Guidelines from the American Society for Blood and Marrow Transplantation

Year: 2015
AGREE II score: Available
Developer organization: American Society for Blood and Marrow Transplantation
A clinical practice guideline for adult and pediatric patients with Hodgkin's lymphoma. The guideline examines the use of autologous stem cell transplant and allogeneic HCT and their appropriateness for patient populations depending on staging. Outcomes of interest include progression-free survival and the use of risk-adapted therapy to improve outcomes.

Management of Chronic Myeloid Leukemia

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for the management of chronic myeloid leukemia (CML) in adult patients over 18 years of age. The 2015 update incorporates new evidence from research involving tyrosine kinase inhibitors for the treatment of CML. Guideline recommendations stem from the following three questions: what diagnostic and baseline investigations are recommended for adult patients with suspected or confirmed CML; what are the recommended treatment options for CML; and what are the criteria for monitoring response to treatment?

Acute Promyelocytic Leukemia

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for the diagnosis and management of acute promyelocytic leukemia (APL) in adult patients over the age of 18 years. As a unique subtype of acute myeloid leukemia (AML), APL has distinct clinical features and management when compared to other forms of AML and therefore, these guidelines serve as a supplement to the AML guidelines. The guideline recommendations are drawn from the following questions: what are the diagnostic criteria for APL; what is the recommended management for adult patients in Alberta with APL; and what is the recommended follow-up for adult patients in Alberta with APL.

Oropharyngeal Cancer Treatment

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for the diagnosis, treatment, and follow-up of oropharyngeal cancer. The guideline examines baseline assessment and imaging, and treatment options based on patient staging. Important aspects include patient treatment preference and prioritization of treatment options based on risk features.

Penile Cancer, Version 3.2015

Year: 2015
AGREE II score: Unavailable
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with squamous cell carcinoma (SCC) of the penis. The guideline reviews risk factors and clinical presentation, and provides recommendations for clinical staging, management of primary legions, management of regional lymph nodes, surveillance, and management of metastatic disease. Surgery, radiotherapy, and chemotherapy are reviewed as treatment options.

Gastric Cancer, Version 3.2015

Year: 2015
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for gastric cancer. The guideline provides an evidence- and consensus-based treatment approach for the management of patients with gastric cancer. Topic areas discussed within the guideline include: staging, principles of pathology, surgery, endoscopic therapies, radiation therapy, combined modality therapy, chemotherapy, and follow-up.

Breast Cancer, Version 3.2015

Year: 2015
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This clinical practice guideline reviews workup, staging, and treatment for both noninvasive and invasive breast cancer. Special considerations include phyllodes tumour, Paget's disease, breast cancer during pregnancy, and inflammatory breast cancer. Treatment recommendations for invasive cancer are stratified by tumour receptor status and stage. Fertility and birth control are also discussed.

Acute Lymphoblastic Leukemia, Version 2.2015

Year: 2015
AGREE II score: Unavailable
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients aged 15 or older with acute lymphoblastic leukemia (ALL). The guideline reviews diagnosis, workup and risk stratification, treatment and consolidation therapy stratified by age and Philadelphia chromosome presence/absence, surveillance, treatment for relapse/refractory disease, and supportive care. The guideline discusses typical immunophenotyping panels for all major subtypes, and minimal residual disease assessment. Evaluation and treatment of extra medullary involvement is also reviewed.

The Management of Uterine Leiomyomas

Year: 2015
AGREE II score: Unavailable
Developer organization: Society of Obstetricians and Gynaecologists of Canada
This clinical practice guideline provides recommendations on the assessment and management of uterine leiomyomas. Treatment options reviewed include medical management, surgical therapies, uterine artery embolization, focused energy delivery systems, MR-guided focused ultrasound, and radiofrequency myolysis. Special considerations are given towards concerns about malignancy and acute uterine bleeding.

Combined Endobronchial and Esophageal Endosonography for the Diagnosis and Staging of Lung Cancer: European Society of Gastrointestinal Endoscopy (ESGE) Guideline, in Cooperation With the European Respiratory Society (ERS) and the European Society of Thoracic Surgeons (ESTS)

Year: 2015
AGREE II score: Available
Developer organization: European Society of Gastrointestinal Endoscopy (ESGE)
This clinical practice guideline discusses the use of combined endobronchial ultrasound (EBUS) and esophageal ultrasound (EUS-(B) for mediastinal nodal staging of lung cancer. The use of EBUS/EUS for the analysis of the primary lung tumour and the left adrenal gland is also discussed. Other topics of consideration include training issues. Outcomes of interest include sensitivity, specificity, diagnostic accuracy, complication rate, and positive and negative predictive values.

A Pan Canadian Practice Guideline for Screening, Assessment, and Management of Cancer-Related Fatigue in Adults: Version 2-2015

Year: 2015
AGREE II score: Available
Developer organization: Canadian Association of Psychosocial Oncology
This is a clinical practice guideline for the screening, assessment and management of cancer-related fatigue in adults. The guideline examines the efficacy of interventions (pharmacological, non-pharmacological, and/or combinations) for reducing cancer-related fatigue in adults and comparisons are made to usual care and attention control. Outcomes of interest include clinically significant improvement in fatigue or clinically significant reduction in cancer-related fatigue (measured by severity) or differences in fatigue severity between intervention group and controls using self-reported outcome measures.

The Role of Endoscopy in Ampullary and Duodenal Adenomas

Year: 2015
AGREE II score: Unavailable
Developer organization: American Society for Gastrointestinal Endoscopy
This is a clinical practice guideline for the use of endoscopic approaches in the evaluation and treatment of ampullary adenomas. The guideline discusses evaluation of ampullary lesions before endoscopic therapy, the role of endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic ultrasound (EUS) in assessment, and endoscopic resection. The role of EUS in management of duodenal adenomas is also examined. Adverse events and post-procedural care and surveillance are also addressed.

The Role of Surgery in the Management of Patients with Diffuse Low Grade Glioma: A Systematic Review and Evidence-Based Clinical Practice Guideline

Year: 2015
AGREE II score: Available
Developer organization: American Association of Neurological Surgeons/ Congress of Neurological Surgeons
This is a clinical practice guideline for patients with diffuse low grade glioma (LGG). More specifically, these guideline recommendations apply to adults with imaging suggestive of a WHO grade 2 glioma (oligodendroglioma, astrocytoma, or oligo-astrocytoma). The central issue addressed in this guideline pertains to whether patients with imaging suggestive of LGG should undergo observation versus treatment involving a surgical procedure.

2015 EAU Guidelines on Muscle-Invasive and Metastatic Bladder Cancer (Limited Updated March 2015)

Year: 2015
AGREE II score: Unavailable
Developer organization: European Association of Urology
This is a clinical practice guideline on muscle-invasive and metastatic bladder cancer. This is an update to the European Association of Urology's 2000 guidelines on bladder cancer and provides recommendations related to staging, diagnostic evaluation, management, and follow-up. Issues addressed include: imaging, surgery, chemotherapy, radiotherapy, and recurrence.

Evidenced-based Clinical Practice Guideline for Upper Tract Urothelial Carcinoma (Summary–Japanese Urological Association, 2014 Edition)

Year: 2015
AGREE II score: Unavailable
Developer organization: Japanese Urological Association
This is a clinical practice guideline for patients with upper tract urothelial carcinoma (UTUC). The guideline provides recommendations on diagnosis and treatment, with discussions on surgery, radiotherapy, chemotherapy and other anticancer drug therapies. Topics include surgical techniques, the use of neoadjuvant versus adjuvant chemotherapy, postoperative follow-up care, the use of ureteroscopic kidney-sparing surgery, instillation of BCG or other anticancer drugs into the upper urinary tract, treatment of metastatic or recurrent UTUC, and use of radiotherapy alone as treatment. Epidemiology is also discussed.

Effective Use of Advanced Practice Nurses in the Delivery of Adult Cancer Services in Ontario

Year: 2015
AGREE II score: Available
Developer organization: Cancer Care Ontario
This guideline provides recommendations on the use of advanced practice nurses (APNs) to optimize patient, provider, and health system outcomes across the cancer care continuum. Specifically, the guideline reviews patient populations and situations (types of needs, practice settings, phase of the cancer care continuum) for which APN roles have demonstrated equivalent or improved outcomes, or reduced harms in cancer care. Outcomes of interest include quality of life, physical, functional, psychosocial, and mental health, as well as morbidity, mortality, symptom management, patient and provider satisfaction, health care utilization, costs, and quality of care.

Clinical Use of Cancer Biomarkers in Epithelial Ovarian Cancer – Updated Guidelines From the European Group on Tumor Markers

Year: 2015
AGREE II score: Unavailable
Developer organization: European Group on Tumor Markers
This is a clinical practice guideline for patients with epithelial ovarian cancer. The guideline examines the clinical use of cancer biomarkers in these patients for the purposes of screening, differential diagnosis, prognosis, and monitoring. Biomarkers discussed include cancer antigen 125 (CA125) and human epididymis protein 4 (HE4). Algorithms for calculating the risk of malignancy index (RMI) including the RMI 1, RMI 2, Assessment of Different NEoplasias (adneXa), and risk of ovarian malignancy algorithm (ROMA), are also discussed.

Provincial Small Cell Lung Cancer Treatment Guidelines

Year: 2015
AGREE II score: Unavailable
Developer organization: Saskatchewan Cancer Agency
This is a clinical practice guideline for patients diagnosed with or suspected of having small cell lung cancer. The guideline reviews screening, work-up, and treatment for limited stage and extensive stage cancer. Recommendations are also provided on follow up care.

Provincial Oral Cavity Cancer Treatment Guidelines

Year: 2015
AGREE II score: Unavailable
Developer organization: Saskatchewan Cancer Agency
This is a clinical practice guideline for the treatment of oral cavity cancer. The guideline addresses staging, pre-treatment investigations. management with recommendations given by cancer stage (stage I and II, advanced (T3) and very advanced (T4B) and by site (anterior tongue, buccal mucosa, floor of mouth, retromolar trigone, and hard palate and alveolar ridge). Follow up care is also reviewed.

ACG Clinical Guideline: Diagnosis and Management of Barrett’s Esophagus

Year: 2015
AGREE II score: Unavailable
Developer organization: American College of Gastroenterology
This is a clinical practice guideline for the diagnosis and management of Barrett's Esophagus (BE). The purpose of this guideline is to review the definition and epidemiology of BE, available screening modalities for BE detection, rationale and methods for surveillance, and available treatment modalities including medical, endoscopic, and surgical techniques. These 2015 guidelines differ markedly from their 2008 predecessor in several areas including: the expanded use of endoscopic ablative therapy, further refinement of screening recommendations, and a better understanding of the impact of gender and anthropomorphics on risk.

The Organization and Delivery of Healthcare Services for Head and Neck Cancer Patients

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for the organization and delivery of health-care services for head and neck cancer patients in Alberta. The recommendations centre around responses to a number of guideline questions including: what does the health-care team treating head and neck cancer patients look like; what are the minimum qualifications required by core team members; what are the minimum cancer centre and team member volumes that optimize clinical outcomes; and what are the unique infrastructure requirements of team members.

Thyroid Carcinoma, Version 2.2015

Year: 2015
AGREE II score: Unavailable
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for the diagnosis, staging, and treatment of thyroid carcinoma. Recommendations are stratified by histologic type, namely papillary, follicular, Hürthle cell, medullary, and anaplastic. Primary treatment options and assessment and management after initial treatment is reviewed. Recurrent or persistent disease is also discussed.

Prostate Cancer, Version 1.2016

Year: 2015
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This clinical practice guideline reviews diagnostic assessment and management of prostate cancer. The guideline discusses risk stratification, molecular testing, and imaging for clinical assessment and staging workup. Management options reviewed include observation, active surveillance, radical prostatectomy, radiation therapy, androgen deprivation therapy, chemotherapy, and immunotherapy, with treatment recommendations stratified by risk. Outcomes of interest include survival and adverse effects of treatment.

Non-Small Cell Lung Cancer, Version 1.2016

Year: 2015
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for adult patients with non-small cell lung cancer. The guideline provides updated recommendations around prevention and screening, evaluation and staging, treatment, and follow up. Areas of focus are discussed with recognition that much progress has been made in regards to screening, minimally invasive techniques for diagnosis and treatment, advances in radiation therapy (RT) including stereotactic ablative radiotherapy (SABR), and targeted therapies.

Non-Hodgkin’s Lymphomas, Version 2.2015

Year: 2015
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for Non-Hodgkin's Lymphomas (NHL). The guideline focuses on recommendations for diagnostic workup, treatment, and surveillance strategies for the most common subtypes of NHL, in addition to a general discussion on the classification systems used in NHL and supportive care considerations. The most common NHL subtypes that are covered in the guideline are: Mature B-cell lymphomas, Mature T-cell and NK-cell lymphomas, Post Transplant Lymphoproliferative Disorders (PTLD), and Castleman's Disease.

Myelodysplastic Syndromes, Version 1.2016

Year: 2015
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for myelodysplastic syndromes (MDS). The guideline provides an update to recommendations on standard approaches to the diagnosis and treatment of MDS in adults. These recommendations are based on a review of recent clinical evidence that has led to important advances in treatment or has yielded new information on biological factors that may have prognostic significance in MDS.

Kidney Cancer, Version 1.2016

Year: 2015
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for kidney cancer. The guideline provides recommendations for the initial evaluation and staging, treatment, and follow-up for adults with various stages of kidney cancer. Topic areas discussed in the guideline include: imaging, surgery, lymph node dissection, targeted therapy, and supportive care.

Esophageal and Esophagogastric Junction Cancers, Version 3.2015

Year: 2015
AGREE II score: Unavailable
Developer organization: National Comprehensive Cancer Network
This clinical practice guideline provides recommendations on esophageal and esophagogastric junction (EGJ) cancers, including: a review of hereditary cancer predisposition syndromes associated with increased risk for esophageal and EGJ cancers, staging and pathology, imaging, and treatment including surgery, radiation therapy, combined modality therapy, chemotherapy, and targeted therapies. Surveillance, management of metastatic, or recurrent cancer, and best supportive care are also discussed. Special topics of interest include treatment and surveillance options for patients with Barrett's esophagus, and suggested strategies to help alleviate the current problems associated with leucovorin shortage.

Cervical Cancer, Version 2.2015

Year: 2015
AGREE II score: Unavailable
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with cervical cancer including squamous cell carcinoma, adenosquamous carcinoma, and adenocarcinoma of the cervix. The guideline discusses diagnosis and workup, principles of staging and surgery, primary treatment, adjuvant treatment, surveillance, and therapy for relapse. Special topics of consideration include incidental cervical cancer, radiation therapy, and cervical cancer and pregnancy.

Oncogenetic Testing and Follow-up for Women With Familial Breast/Ovarian Cancer, Li-Fraumeni Syndrome and Cowden Syndrome

Year: 2015
AGREE II score: Available
Developer organization: Belgian Health Care Knowledge Centre
This is a clinical practice guideline for adult women (18 years and older) either without breast cancer or with a recent diagnosis of breast cancer, who have a family history of breast, ovarian or a related cancer; the guideline also provides recommendations for men affected by male breast cancer. The guideline discusses oncogenetic testing aspects of breast cancer and ovarian, specifically hereditary breast cancer, the Li-Fraumeni syndrome, and the Cowden syndrome. Topics include criteria and indications for genetic testing, tests for which genes have clinical utility, and appropriate follow-up depending on results and family history.

Oncogenetic Testing, Diagnosis and Follow-up in Birt-Hogg-Dubé Syndrome, Familial Atypical Multiple Mole Melanoma Syndrome and Neurofibromatosis 1 and 2

Year: 2015
AGREE II score: Available
Developer organization: Belgian Health Care Knowledge Centre
This is a clinical practice guideline for patients at risk of Birt-Hogge-Dubé Syndrome, the familial atypical multiple mole melanoma syndrome and neurofibromatosis 1&2, either based on clinical suspicion or family history. The guideline reviews indications for genetic testing, clinical utility of specific genetic tests, and follow-up depending on test results and family history. Impact of genetic counselling and test on patient behaviour and distress levels is also reviewed.

The Role of Endoscopy in the Management of Premalignant and Malignant Conditions of the Stomach

Year: 2015
AGREE II score: Unavailable
Developer organization: American Society for Gastrointestinal Endoscopy
This clinical practice guideline discusses the use of endoscopy in patients with malignant and premalignant conditions of the stomach including gastric polyps, gastric intestinal metaplasia (GIM), pernicious anemia, gastric carcinoid tumours, adenocarcinoma, mucosa-associated lymphoid tissue (MALT) lymphoma, and GI stromal tumours (GISTs). Surveillance endoscopy, staging ultrasound, biopsy, polypectomy, resection (surgical and endoscopic), and open gastrojejunostomy are discussed. Outcomes of interest include risk factors for dysplasia and gastric cancer, as well as survival rate, accuracy of staging techniques, and treatment complication rate.

The Japanese Breast Cancer Society Clinical Practice Guideline for Screening and Imaging Diagnosis of Breast Cancer

Year: 2015
AGREE II score: Unavailable
Developer organization: Japanese Breast Cancer Society
A clinical practice guideline for women who may be at risk for breast cancer. The guideline examines effective screening and diagnosis methods, focusing on mammography with comparisons made to imaging techniques. Outcomes of interest include breast cancer outcomes, screening sensitivity, and accuracy.

The Role of Biopsy in the Management of Patients with Presumed Diffuse Low Grade Glioma: A Systematic Review and Evidence-Based Clinical Practice Guideline

Year: 2015
AGREE II score: Available
Developer organization: American Association of Neurological Surgeons/ Congress of Neurological Surgeons
This clinical practice guideline is for adult patients with imaging suggestive of low-grade glioma. The guideline discusses the optimal role of biopsy in the initial management of presumptive low-grade glioma, and provides recommendations on the best technique for biopsy. Primary outcomes of interest include diagnostic accuracy, morbidity and mortality. Advanced imaging for tumor targeting is also discussed.

Consensus Recommendations for the Diagnosis and Management of Hemophagocytic Lymphohistiocytosis Associated With Malignancies

Year: 2015
AGREE II score: Unavailable
Developer organization: Study Group on HLH Subtypes of the Histiocyte Society
This is a clinical practice guideline on the hyperinflammatory syndrome hemophagocytic lymphohistiocytosis (HLH). As the developers state, HLH can occur in the context of malignancies and malignancy-triggered HLH should be regarded separately from HLH during chemotherapeutic treatment, which is frequently associated with an infectious trigger. Because the overlap between the features of HLH and the features of neoplasms makes it difficult to identify HLH when it occurs in malignant conditions, the guideline developers focus their recommendations on the recognition and diagnostic workup, as well as the treatment of malignancy-associated HLH.

Pulmonary Neuroendocrine (Carcinoid) Tumors: European Neuroendocrine Tumor Society Expert Consensus and Recommendations for Best Practice for Typical and Atypical Pulmonary Carcinoids

Year: 2015
AGREE II score: Unavailable
Developer organization: European Neuroendocrine Tumor Society
A clinical practice guideline for patients with pulmonary neuroendocrine (carcinoid) tumours, including typical and atypical presentations. The guideline examines diagnosis and staging, primarily through pathology and contract CT, and treatment focusing on surgical management.

Guidelines of the Brazilian Dermatology Society for Diagnosis, Treatment and Follow Up of Primary Cutaneous Melanoma – Part I

Year: 2015
AGREE II score: Unavailable
Developer organization: Brazilian Dermatology Society
A clinical practice guideline for patients with primary cutaneous melanoma. The guideline examines the use of dermoscopy for diagnosis, and treatment including appropriate surgical margins. Outcomes of interest include prognostic improvement, aesthetic impairment, and cure rates.

Lower Urinary Tract Symptoms in Men: Assessment and Management

Year: 2015
AGREE II score: Available
Developer organization: National Institute for Health and Care Excellence
This is a clinical practice guideline offers best practice advice on the care of men with lower urinary tract symptoms (LUTS). The guideline provides recommendations on the effective evidence-based management of LUTS. Areas covered in the guideline include discussion of: initial assessment, conservative management, surgery, and drug treatment. The guideline also provides recommendations on how to best ensure men with LUTS have access to care that addresses their psychosocial issues.

Australian Clinical Practice Guidelines for the Diagnosis and Management of Barrett’s Esophagus and Early Esophageal Adenocarcinoma

Year: 2015
AGREE II score: Available
Developer organization: Cancer Council Australia
This is a clinical practice guideline for patients with Barrett's esophagus (BE) without dysplasia and BE with dysplasia and/or early esophageal adenocarcinoma (EAC). Topics of discussion include: endoscopic and histological definitions of BE and early EAC; prevalence, incidence, natural history, and risk factors for BE and early EAC; and management of BE and early EAC, including modification of lifestyle factors, screening, surveillance, and medical, endoscopic, and surgical interventions.

ACR Appropriateness Criteria Nasopharyngeal Carcinoma

Year: 2015
AGREE II score: Available
Developer organization: American College of Radiology
This is a clinical practice guideline for adults with nasopharyngeal carcinoma. Clinical presentation and evaluation is reviewed, and treatment recommendations are provided for Stage I, II, and III or IV disease. Treatment of recurrent or metastatic disease is also discussed. Outcomes of interest include toxicity from treatment, overall survival, progression-free survival, and distant control.

Provincial Head and Neck Cancer Treatment Guidelines

Year: 2015
AGREE II score: Unavailable
Developer organization: Saskatchewan Cancer Agency
A clinical practice guideline for head and neck cancers, with specific epidemiological information for nasopharyngeal cancer. The guideline examines diagnostic work-up, follow-up, and treatment, primarily through systemic and chemotherapy treatments. Outcomes of interest include reduced local and distant failures through appropriate risk identification and improved regimens for induction chemotherapy.

JGES Guidelines for Colorectal Endoscopic Submucosal Dissection/Endoscopic Mucosal Resection

Year: 2015
AGREE II score: Unavailable
Developer organization: Japan Gastroenterological Endoscopy Society
A clinical practice guideline for the use of colorectal endoscopic submucosal dissection and endoscopic mucosal resection in patients with colorectal cancer. The guideline examines diagnostic indications, perioperative diagnosis, treatment techniques, and postoperative care. Outcomes of interest include recurrence, curability, and delayed bleeding/perforation.

Clinical Practice Guidelines for the Management of Biliary Tract Cancers 2015: the 2nd English Edition

Year: 2015
AGREE II score: Unavailable
Developer organization: Japanese Society of Hepato-Biliary-Pancreatic Surgery
This is a clinical practice guideline for the diagnosis and management of biliary tract cancers. The guidelines consist of algorithms that outline diagnosis and treatment followed by clinical questions regarding seven topics: prophylactic treatment, diagnosis, biliary drainage, surgical treatment, chemotherapy, radiation therapy, and pathology. Recommendations are therefore drawn from these clinical questions, and include recommendations as to what the first step in the diagnosis of the biliary tract cancers is, what the appropriate procedure for preoperative biliary drainage is and when it should be performed, and whether radiation therapy is useful for patients with unresectable biliary tract cancer.

Revised American Thyroid Association Guidelines for the Management of Medullary Thyroid Carcinoma: The American Thyroid Association Guidelines Task Force on Medullary Thyroid Carcinoma

Year: 2015
AGREE II score: Unavailable
Developer organization: American Thyroid Association
This is a clinical practice guideline for the diagnosis and management of medullary thyroid carcinoma (MTC) in both pediatric and adult patients. Recommendations are organized by sections that include: ethical considerations for genetic screening, surgical treatment, treatment of patients with hormonally active metastases, and hormone replacement. Although the guideline group acknowledges that there has been significant advances in the diagnosis and treatment of patients with MTC, they close with a statement around the fact that there is critical need for more effective therapies for patients with advanced MTC.

Merkel Cell Carcinoma

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adults over the age of 18 years with Merkel cell carcinoma of the skin. The guideline provides recommendations on staging and work-up, treatment options including surgery, radiation, and chemotherapy, and follow-up care. The guideline also provides recommendations on management of recurrences, and reviews sentinel lymph node biopsy protocol.

American Gastroenterological Association Institute Guideline on the Diagnosis and Management of Asymptomatic Neoplastic Pancreatic Cysts

Year: 2015
AGREE II score: Available
Developer organization: American Society of Clinical Oncology
This is a clinical practice guideline for adults with pancreatic cysts. The guideline evaluates the evidence for diagnosing and managing pancreatic cysts. Important aspects discussed in the guideline include the taking of a detailed patient history, the use of imaging, and surgery. Outcomes of interest include the prevention of mortality from cystadenocarcinoma, the appropriateness of surgical intervention, and the progression of malignancy.

Survivorship, Version 2.2015

Year: 2015
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
These clinical practice guidelines for survivorship provide screening, evaluation, and treatment recommendations for common consequences of cancer and cancer treatment to aid health-care professionals who work with survivors of adult-onset cancer in the post-treatment period, including those in specialty cancer survivor clinics and primary care practices. The guidelines focus on the vast and persistent impact both the diagnosis and treatment of cancer can have on the adult survivor’s health, physical and mental states, health behaviours, professional and personal identity, sexuality, and financial standing.

Testicular Cancer, Version 1.2016

Year: 2015
AGREE II score: Unavailable
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with testicular cancer. The guideline provides recommendations on clinical presentation, diagnostic workup, risk assessment, and treatment. Management options are stratified by stage and cancer type (seminoma or nonseminoma). Second-line therapy for metastatic germ cell tumours is reviewed with recommendations provided for palliative therapy and treatment of brain metastases.

Malignant Pleural Mesothelioma, Version 2.2015

Year: 2015
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for mesothelioma. The guideline focuses on the diagnosis and management of malignant pleural mesothelioma (MPM). Topic areas discussed in the guideline include: surgery, chemotherapy, and radiation therapy.

Bone Cancer, Version1.2016

Year: 2015
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This clinical practice guideline reviews workup and treatment of bone cancer, with specific recommendations provided for chondrosarcoma, chordoma, Ewing's sarcoma family of tumours, and osteosarcoma. Surveillance and relapse are also reviewed. An overview of systemic therapy agents is provided, and principles of radiation therapy are discussed.

Suspected Cancer: Recognition and Referral

Year: 2015
AGREE II score: Available
Developer organization: National Institute for Health and Care Excellence
This is a clinical practice guideline for patients of all age groups suspected of having cancers including lung and pleural, upper gastro-intestinal, lower gastrointestinal, breast, gynecological, urological, skin, head and neck, brain and central nervous system, haematological, sarcomas, and childhood cancers. Recommendations are provided on recognition and referral or investigations of cancer in primary care. Outcomes of interest include quality of life, sensitivity and specificity of diagnostic tests and signs/symptoms, positive and negative predictive values of diagnostic tests and signs/symptoms, and cost effectiveness.

2nd ESMO Consensus Conference in Lung Cancer: Locally Advanced Stage III Non-Small-Cell Lung Cancer

Year: 2015
AGREE II score: Unavailable
Developer organization: European Society for Medical Oncology
This is a clinical practice guideline for patients with locally advanced stage III non-small-cell lung cancer (NSCLC). The guideline reviews heterogeneity in disease and provides recommendations on sub-staging, diagnostic work-up, assessment of relevant comorbidities, and treatment including chemotherapy, radiation, multi-modality therapies, surgical management, and targeted agents. Follow-up is also discussed. Outcomes of interest include mortality, survival (5 year, long-term), remission rates, and toxicity.

Guidelines for the Diagnosis and Management of Acute Myeloid Leukaemia in Pregnancy

Year: 2015
AGREE II score: Unavailable
Developer organization: British Committee for Standards in Haematology
This is a clinical practice guideline for the diagnosis and management of acute myeloid leukaemia in pregnancy. The guideline considers the unique challenges pregnancy poses as it relates to diagnosing and managing acute myeloid leukaemia in patients. Important topics discussed in this guideline include: issues of management in the first trimester versus that of the second and third trimesters, chemotherapy and complications, teratogenic risk, as well as supportive therapies in pregnancy.

The Role of Imaging in the Management of Adults with Diffuse Low Grade Glioma: A Systematic Review and Evidence-Based Clinical Practice Guideline

Year: 2015
AGREE II score: Available
Developer organization: American Association of Neurological Surgeons/ Congress of Neurological Surgeons
This is a clinical practice guideline for adults with a newly diagnosed lesion with a suspected or histopathologically proven low grade glioma (LGG). The objectives of the guideline are to provide recommendations on the role of imaging for management of LGG including optimal imaging techniques for both diagnsosis and follow-up, as well as imaging sequence and parameters. Techniques discussed include anatomic MR imaging, perfusion weighted MR imaging, diffusion weighted MR imaging, MR spectroscopy, PET and SPECT imaging. Primary outcome of interest is diagnostic specificity, as well as sensitivity and predicitve data.

Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer Adapted for Nova Scotia

Year: 2015
AGREE II score: Unavailable
Developer organization: Cancer Care Nova Scotia
This clinical practice guideline addresses care of adult patients with differentiated thyroid cancer, specifically within Nova Scotia. The guideline provides recommendations on pre-surgical evaluation of thyroid nodules, surgical treatment and complications, pathology reporting, grading and tumour staging (TNM), risk prognostic systems, and post-surgical radioactive iodine (RAI) therapy. Protocols for lab and diagnostic follow-up, management of local and regional recurrences, early and long-term follow-up, and supportive and palliative care management are also addressed.

ACR Appropriateness Criteria Pretreatment Planning of Invasive Cancer of the Cervix

Year: 2015
AGREE II score: Available
Developer organization: American College of Radiology
This is a clinical practice guideline for patients with invasive cancer of the cervix. The guideline addresses staging techniques using imaging. This includes a review of the use of radiographs, excretory urography, transabdominal ultrasound (TRUS), computed tomography (CT), magnetic resonance imaging (MRI), lymphangiography and lymphoscintigraphy, positron emission tomography (PET) and PET/computed tomography, and nuclear medicine bone scan. Trachelectomy assessment is also discussed.

The Role of Deep Enteroscopy in the Management of Small-bowel Disorders

Year: 2015
AGREE II score: Unavailable
Developer organization: American Society for Gastrointestinal Endoscopy
This clinical practice guideline discusses the use of deep enteroscopy (DE) in the management of small-bowel disorders including diagnosis and therapeutic intervention of small-bowel tumours. The guideline compares different DE techniques including double-balloon enteroscope (DBE) single-balloon enteroscope (SBE), and the Endo-Ease Discovery SB (SE). Safety and efficacy are the primary outcomes of interest.

Guideline for Referral of Patients with Suspected Prostate Cancer by Family Physicians and Other Primary Care Providers

Year: 2015
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for referral of patients with suspected prostate cancer by family physicians and other primary care providers. More specifically, the guidelines provide recommendations for referral based on digital rectal examination (DRE) findings and prostate-specific antigen (PSA) test results. The research questions that guided the development of recommendations included: what signs, symptoms, and other clinical features that present in primary care are predictive of prostate cancer; what is the diagnostic accuracy of investigations commonly considered for patients presenting with signs and/or symptoms of prostate cancer; and what major, known risk factors increase the likelihood of prostate cancer in patients presenting with signs and/or symptoms of prostate cancer.

Japanese Society for Cancer of the Colon and Rectum (JSCCR) Guidelines 2014 for Treatment of Colorectal Cancer

Year: 2015
AGREE II score: Unavailable
Developer organization: Japanese Society for Cancer of the Colon and Rectum (JSCCR)
This is a clinical practice guideline for the treatment of colorectal cancer. The overarching aim of the guideline is to provide standard treatment strategies for colorectal cancer, to eliminate treatment disparities among institutions, to eliminate unnecessary treatment and insufficient treatment, and to deepen mutual understanding among health-care professionals and patients. Issues addressed include: surgical treatment, treatment strategies after resection, as well as palliative care options.

Adenocarcinoma of the Pancreas

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients with adenocarcinoma of the pancreas. The guideline discusses diagnostic workup, treatment options for potentially curable adenocarcinoma of the pancreas, and management of unresectable adenocarcinoma of the pancreas including locally advanced and metastatic disease. Surgical and first and second line systemic treatment options are discussed. Toxicity of systemic therapy regimes is also reviewed.

Acute Myeloid Leukemia

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients over the age of 18 years with acute myeloid leukemia. The guideline reviews diagnosis, classification, ancillary tests, response criteria, prognosis/risk stratification, risk groups as per cytogenetic or molecular status, and management options. Treatments reviewed include chemotherapy, hematopoietic stem cell transplantation, and palliation. Follow up care is also discussed.

Oncogenetic Testing for Persons With Hereditary Endocrine Cancer Syndromes

Year: 2015
AGREE II score: Available
Developer organization: Belgian Health Care Knowledge Centre
This clinical practice guideline discusses genetic testing for patients diagnosed with or suspected of having hereditary endocrine cancer syndromes, specifically multiple endocrine neoplasia type 2 (MEN2), multiple endocrine neoplasia type 1 (MEN1), Von Hippel-Lindau (VHL) syndrome, and paraganglioma and phaeochromocytoma. Indications for genetic testing of relatives of patients is also reviewed. Genetic testing for Succinate Dehydrogenase B, C and D (SDHB, SDHC, SDHD), menin, VHL and RET mutations are discussed. Outcomes of interest include diagnostic accuracy, health outcomes, and psychosocial outcomes.

ACG Clinical Guideline: Genetic Testing and Management of Hereditary Gastrointestinal Cancer Syndromes

Year: 2015
AGREE II score: Unavailable
Developer organization: American College of Gastroenterology
This is a clinical practice guideline for patients diagnosed with or at risk of hereditary gastrointestinal cancer syndromes including lynch syndrome, familial adenomatous polyposis (FAP), attenuated familial adenomatous polyposis (AFAP), MUTYH-associated polyposis (MAP), Peutz–Jeghers syndrome, juvenile polyposis syndrome, Cowden syndrome, serrated (hyperplastic) polyposis syndrome, hereditary pancreatic cancer, and hereditary gastric cancer. The guideline reviews initial assessment, genetic testing for a germline mutation when indicated, pre- and post-test genetic counselling, and management of patients who meet clinical criteria for a syndrome as well as those with identified pathogenic germline mutations. Outcomes of interest include cancer risk, quality of life, and survival benefit from surveillance.

Guidelines for the Diagnosis and Management of Intrahepatic Cholangiocarcinoma

Year: 2014
AGREE II score: Unavailable
Developer organization: International Liver Cancer Association (ILCA)
This is a clinical practice guideline for patients diagnosed with or suspected of having intrahepatic cholangiocarcinoma (iCCA). The guideline discusses iCCA incidence, risk factors, and molecular pathogenesis, and provides recommendations on diagnostic assessment, staging, and management. Treatment options including surgery, liver transplantation, loco-regional therapy, and systemic therapy are discussed. Outcomes of interest include survival (recurrence-free, median, three-year, five-year), quality of life, and toxicity.

Oral Cavity Cancer: Diagnosis, Treatment and Follow-Up

Year: 2014
AGREE II score: Available
Developer organization: Belgian Health Care Knowledge Centre
A clinical practice guideline for patients with oral cavity cancers. The guideline examines diagnosis, treatment, and follow-up with a focus on radiotherapy and appropriate imaging techniques. Outcomes of interest include improved supportive care through nutritional therapy and improved follow-up timing.

Genital Tract Cancers in Females: Endometrial Cancer

Year: 2014
AGREE II score: Unavailable
Developer organization: Guidelines and Protocols Advisory Committee
This is a clinical practice guideline for female patients aged 19 and older. The guideline provides recommendations on the screening, diagnosis, treatment, and follow-up care of endometrial cancer. Prevention and risk reduction strategies are also discussed.

Advanced Imaging for Detection and Differentiation of Colorectal Neoplasia: European Society of Gastrointestinal Endoscopy (ESGE) Guideline

Year: 2014
AGREE II score: Available
Developer organization: European Society of Gastrointestinal Endoscopy (ESGE)
A clinical practice guideline for patients with suspected colorectal neoplasia. The guideline examines diagnosis and differentiation through endoscopic imaging, including virtual and conventional methods. Outcomes of interest include improved lesion characterization and improved detection of hereditary syndromes.

British Thyroid Association Guidelines for the Management of Thyroid Cancer

Year: 2014
AGREE II score: Available
Developer organization: British Thyroid Association
A clinical practice guideline for the management of patients with differentiated and medullary thyroid cancer. The guideline examines the management of thyroid cancer from diagnosis to follow-up, with specific focus on radioiodine remnant ablation and appropriate post-treatment follow-up. Outcomes of influence include improved outcomes in total thyroidectomy and improved personalised decision making.

Provincial Hepatocellular Cancer Treatment Guidelines

Year: 2014
AGREE II score: Unavailable
Developer organization: Saskatchewan Cancer Agency
A clinical practice guideline for adult and pediatric hepatocellular cancer patients. The guideline examines assessment and treatment for both curative and non-curative therapies. Outcomes of interest include clarified follow-up timing and early involvement of supportive care.

Provincial Biliary Tract & Gall Bladder Cancer Treatment Guidelines

Year: 2014
AGREE II score: Unavailable
Developer organization: Saskatchewan Cancer Agency
A clinical practice guideline for patients with biliary tract and gall bladder cancers. The guidelines examines assessment and treatment based on disease staging or re-staging, primarily thought chemotherapy or surgery. Outcomes of interest include improved nutritional supplementation and reduced need for follow-up imaging.

Saudi Oncology Society Clinical Management Guideline Series: Esophageal Cancer 2014

Year: 2014
AGREE II score: Unavailable
Developer organization: Saudi Oncology Society
A clinical practice guideline for the management of esophageal cancer. The guideline examines pre-treatment workup, staging, and treatment, primarily through surgical methods. Outcomes of interest include more complete esophageal dissection and clarified options for palliative care.

Pheochromocytoma and Paraganglioma: An Endocrine Society Clinical Practice Guideline

Year: 2014
AGREE II score: Unavailable
Developer organization: The Endocrine Society
This is a clinical practice guideline for patients suspected of having or diagnosed with pheochromocytoma and paraganglioma (PPGL). Recommendations are provided for diagnostic biochemical testing, imaging studies, genetic testing, perioperative medical management, and surgery. The guideline also discusses personalized management of PPGLs with recognition of the distinct genotype-phenotype presentations of hereditary PPGLs. Outcomes of interest include sensitivity of diagnostic tests, rates of metastasis or recurrence after treatment, and peri- and post-operative complications.

Guidelines on Muscle-Invasive and Metastatic Bladder Cancer

Year: 2014
AGREE II score: Available
Developer organization: European Association of Urology
A clinical practice guideline for the management of muscle-invasive and metastatic bladder cancer. The guideline examines diagnosis and staging with specific focus on imaging recommendations, including MRI and CT. Treatment options, including radical chemotherapy and surgery are also discussed based on imaging results. Outcomes of interest include improved treatment selection, specifically in cases where previous treatments have failed.

British Association of Dermatologists’ Guidelines for the Management of Squamous Cell Carcinoma In Situ (Bowen’s Disease) 2014

Year: 2014
AGREE II score: Available
Developer organization: British Association of Dermatologists
This is a clinical practice guideline for the diagnosis and treatment of squamous cell carcinoma in situ (Bowen's disease). Various treatment options are compared with attention to invasiveness of therapy and cost, complexity, and general availability of required equipment. Other outcomes of interest include treatment efficacy, aesthetic result, wound healing, and morbidity.

Guidelines for the Diagnosis and Management of Multiple Myeloma 2014

Year: 2014
AGREE II score: Unavailable
Developer organization: British Committee for Standards in Haematology
This is a clinical practice guideline for patients with suspected or confirmed multiple myeloma. Diagnostic procedures are recommended and treatment options outlined, including chemotherapy, induction therapy, high-dose therapy and autologous stem cell transplantation (ASCT), and allogeneic stem cell transplantation (AlloSCT). Recommendations are also provided for maintenance therapy and the treatment of medical conditions common in patients with myeloma. Outcomes of interest include treatment response rate, survival, toxicity, quality of life, and treatment-related mortality.

British HIV Association Guidelines for HIV-Associated Malignancies 2014

Year: 2014
AGREE II score: Available
Developer organization: British HIV Association
This is a clinical practice guideline for the diagnosis and treatment of cancer and associated malignancies in adult patients with HIV. The guideline examines the most common HIV associated cancers, Kaposi sarcoma, high grade B-cell non-Hodgkin lymphoma and invasive cervical cancer, as well as a number of other cancers with higher risk profiles in HIV patients. Outcomes of interest include improved treatment options in consideration of HAART and increased prophylactic options in low-risk patients, specifically with regards to lifestyle changes and vaccinations.

Breast Cancer Screening Clinical Practice Guideline

Year: 2014
AGREE II score: Available
Developer organization: Kaiser Permanente
This clinical practice guideline addresses breast cancer screening in asymptomatic women. Risk factors are discussed and recommendations are stratified by age and risk. Outcomes include risk estimates, over- and under- diagnosis harms, and screening effectiveness.

Optimization of Preoperative Assessment in Patients Diagnosed with Rectal Cancer

Year: 2014
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for patients with rectal cancer who are newly diagnosed. The guideline provides recommendations on investigations to assess for metastases and synchronous lesions, imaging for local staging, optimal MRI protocol and criteria for local staging, optimal MRI criteria to select patients for neoadjuvant therapy, the role of multidisciplinary cancer conferences and the role of restaging MRI after neoadjuvant therapy.

Molecular Testing for Selection of Patients With Lung Cancer for Epidermal Growth Factor Receptor and Anaplastic Lymphoma Kinase Tyrosine Kinase Inhibitors: American Society of Clinical Oncology Endorsement of the College of American Pathologists/International Society for the Study of Lung Cancer/Association of Molecular Pathologists Guideline

Year: 2014
AGREE II score: Available
Developer organization: American Society of Clinical Oncology
This is a clinical practice guideline endorsement for the selection of patients with lung cancer for epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors. The guideline addresses five principal questions including considerations about when molecular testing should be performed, the manner in which EGFR testing should be performed, and whether other genes should be routinely tested in lung adenocarcinoma. Other areas of interest include recommendations as to how EGFR and ALK testing should be validated, and how best to maintain quality control and quality assurance policies and procedures for EGFR and ALK testing in lung cancers.

Hereditary Colorectal Cancer Syndromes: American Society of Clinical Oncology Clinical Practice Guideline Endorsement of the Familial Risk–Colorectal Cancer: European Society for Medical Oncology Clinical Practice Guidelines

Year: 2014
AGREE II score: Available
Developer organization: American Society of Clinical Oncology
This is a clinical practice guideline endorsement for people at risk for hereditary colorectal cancer (CRC) syndromes. The guideline provides recommendations on prevention, screening, genetics, treatment, and management. Topics of interest addressed in the guideline include: tumour testing for DNA mismatch repair (MMR) deficiency, genetic testing for Lynch syndrome, as well as follow-up recommendations in mutation carriers.

Oral Cavity Cancer

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for patients with suspected or diagnosed oral cavity cancer. The guideline examines diagnosis, treatment, and potential reconstruction depending on cancer stage and site-specificity. Outcomes of interest include improved functional outcomes through reconstruction and improved adjuvant therapy for patients with increased risk factors.

Management of Primary Germ Cell Tumours of the Central Nervous System

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients over the age of 18 years with primary germ cell tumours (GCTs) of the central nervous system. The guideline discusses staging and diagnosis, treatment, and follow-up care. Recommendations for treatment options are provided for germinoma and nongerminomatous GCT, and are stratified by whether disease is localized or metastatic. Additional recommendations are made for recurrent treatment, again stratified by histology.

Management of Recurrent High-Grade Gliomas

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adults over the age of 18 years with recurrent high-grade gliomas, including grade III anaplastic astrocytomas, anaplastic oligodendrogliomas, anaplastic oligoastrocytomas and grade IV glioblastomas. The guideline discusses diagnostic assessment for recurrence, and treatment options including systemic therapy, surgery, and re-irradiation. Factors of consideration when determining treatment course are also discussed.

Care of the Adult Patient With a Brain Tumour

Year: 2014
AGREE II score: Unavailable
Developer organization: American Brain Tumor Association
A clinical practice guideline for adult patients with brain tumours, specifically focusing on nursing activities. The guideline examines management from diagnosis to survivorship or end-of-life care, with specific focus on symptom management and communication with patients and family. Outcomes of interest include improved patient education and supportive communication..

The Role of Neuropathology in the Management of Progressive Glioblastoma: A Systematic Review and Evidence-based Clinical Practice Guideline

Year: 2014
AGREE II score: Available
Developer organization: Joint Guidelines Committee of the Congress of Neurological Surgeons and American Association of Neurological Surgeons
This is a clinical practice guideline for adult patients with progressive glioblastoma. The guideline reviews diagnostic criteria and provides recommendations on techniques and ancillary studies that are most useful in separating malignant progression from treatment effect. Outcomes of interest include sensitivity, specificity, positive and negative predictive value, accuracy, and likelihood ratio of a positive and negative result.

Provincial Pancreatic Cancer Treatment Guidelines

Year: 2014
AGREE II score: Unavailable
Developer organization: Saskatchewan Cancer Agency
A clinical practice guideline for patients with pancreatic cancer. The guideline examines assessment and treatment, primarily through radical resections including Whipple procedures. Outcomes of interest include reduced chemotherapy toxicity with gemcitabine and improved follow-up procedures.

Provincial Gastric and Gastro-Esophageal Junction Cancer Treatment Guidelines

Year: 2014
AGREE II score: Unavailable
Developer organization: Saskatchewan Cancer Agency
A clinical practice guideline for gastric and gastro-esophageal junction cancer patients. The guidelines examines assessment by a multidisciplinary team, and treatment options including gastrectomy and endomucosal resection. Outcomes of interest include increased survival through combination therapy and potential benefit from biomarker targeted therapies.

Saudi Oncology Society Clinical Management Guideline Series: Anal Canal Cancer 2014

Year: 2014
AGREE II score: Unavailable
Developer organization: Saudi Oncology Society
This is a clinical practice guideline for patients with anal canal cancer. The guideline provides recommendations for the pre-treatment evaluation, staging, and treatment options. Recommendations include a consideration of the appropriateness of x-ray, CT, and MRI; the American Joint Commission on Cancer pathological staging system; as well as resection, chemotherapy and radiotherapy.

Diagnosis, Treatment, and Follow-up of Medullary Thyroid Carcinoma: Recommendations by the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism

Year: 2014
AGREE II score: Unavailable
Developer organization: Brazilian Society of Endocrinology and Metabolism
This is a clinical practice guideline for individuals with or suspected of having Medullary thyroid carcinoma (MTC). The guideline provides recommendations on diagnosis, surgical treatment, and follow-up care. The use of chemotherapy and/or radiotherapy in the management of individuals with metastatic MTC is also discussed. The appropriate use of RET proto-oncogene molecular testing during diagnostic assessment is discussed, and the potential value in the use of tyrosine-kinase inhibitors as a treatment option is reviewed. Outcomes of interest include survival rate (median, overall, 10-year, progression-free), sensitivity and specificity of diagnostic tests, cure rate, rate of remission, and recurrence rate.

Extended Pancreatectomy in Pancreatic Ductal Adenocarcinoma: Definition and Consensus of the International Study Group for Pancreatic Surgery (ISGPS)

Year: 2014
AGREE II score: Unavailable
Developer organization: International Study Group on Pancreatic Surgery (ISGPS)
This is a clinical practice guideline for ductal adenocarcinoma of the pancreas. The guideline provides recommendations for extended pancreatectomy. Related topics examined in this guideline include: resectability, perioperative morbidity and mortality, and prognosis.

Head and Neck Cancer

Year: 2014
AGREE II score: Unavailable
Developer organization: BC Cancer Agency
This guideline set provides recommendations on the management of head and neck cancers including oral and dental care. Topics of discussion include predisposing factors, prevention, screening, early detection, diagnosis and staging, management, and follow-up. Additionally, oral care through chemotherapy, radiation therapy, and bone marrow transplantation are discussed. Please note that the sub-sections within this set were published and revised at varying dates, and that the publication year referenced here refers only to the date that the guideline set was accessed online.

Gynecology Cancer

Year: 2014
AGREE II score: Unavailable
Developer organization: BC Cancer Agency
This guideline set provides recommendations on the management of gynecologic cancers including gynecological sarcomas and cancers of the ovary (epithelial and non-epithelial carcinomas), endometrium, uterine cervix, vulva, fallopian tube, gestational trophoblastic neoplasia, and vagina. Topics of discussion include diagnosis and staging, management, and follow-up. Additionally, prevention and screening are discussed for ovarian, endometrial, and cervical cancers. Please note that the sub-sections within this set were published and revised at varying dates, and that the publication year referenced here refers only to the date that the guideline set was accessed online.

Clinical Practice Guidelines for the Management of Adult Onset Sarcoma

Year: 2014
AGREE II score: Available
Developer organization: Cancer Council Australia
This is a clinical practice guideline for adults suspected of having or diagnosed with adult onset sarcoma. The guideline provides recommendations on diagnosis and staging, treatment, and follow-up care. Chemotherapy, radiotherapy, and surgery are discussed as treatment options. Outcomes of interest include local recurrence, survival (overall, long term), and quality of life.

Soft Tissue and Visceral Sarcomas: ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-Up

Year: 2014
AGREE II score: Unavailable
Developer organization: European Society for Medical Oncology
This is a clinical practice guideline for adults diagnosed with or suspected of having soft tissue or visceral sarcoma. The guideline discusses diagnosis, staging and risk assessment, and treatment stratified by whether disease type is localized or advanced. Follow-up care is also reviewed. Treatment options for patients with special presentations and entities is also discussed, including patients with retroperitoneal sarcomas, uterine sarcomas, desmoid-type fibromatosis, and breast sarcomas.

Saudi Oncology Society Clinical Management Guideline Series: Pancreatic Cancer 2014

Year: 2014
AGREE II score: Unavailable
Developer organization: Saudi Oncology Society
This clinical practice guideline provides recommendations on pancreatic cancer management including pre-treatment evaluation, surgical pathology report requirements, staging classifications, assessment of resectability, and treatment. Pancreatico-duodenectomy, radiotherapy, chemoradiotherapy, and chemotherapy are discussed as treatment options depending on resectability. Management of metastatic pancreatic cancer and locally recurrent disease are included in this review.

Saudi Oncology Society Clinical Management Guideline Series: Colorectal Cancer 2014

Year: 2014
AGREE II score: Unavailable
Developer organization: Saudi Oncology Society
This is a clinical practice guideline for the pre-treatment evaluation, staging, and treatment of colorectal cancer. Topics addressed in the guideline include an overview of surgical pathology report requirements; as well as treatment options for clinically localized resectable colon cancer, clinically localized resectable rectal cancer, and locally advanced unresectable or metastatic colon or rectal cancer.

British Society of Gastroenterology Guidelines on the Diagnosis and Management of Barrett’s Oesophagus

Year: 2014
AGREE II score: Available
Developer organization: British Society of Gastroenterology
This is a clinical practice guideline for Barrett’s oesophagus and related early neoplasia. The guideline provides recommendations to guide patient management. The guideline addresses issues in Barrett’s oesophagus including: definition, screening and diagnosis, surveillance, pathological grading for dysplasia, management of dysplasia, and early cancer including training.

Required Reports for Referrals

Year: 2014
AGREE II score: Unavailable
Developer organization: BC Cancer Agency
This guideline set provides recommendations on required reports for referrals for: breast, gastrointestinal (esophagus, stomach, colon-rectum, anus, pancreas, liver, biliary tract/gall bladder), genitourinary (testis, prostate, bladder), gynecology (endometrium, cervix, ovary, vulva & vagina), head and neck (parotid & submandibular gland, thyroid, mouth, palate, nasopharynx, oropharynx, hypopharynx, nose & antrum, ear), lung, lymphoma and leukemia, melanoma, musculoskeletal and sarcoma, neuro-oncology, primary unknown, and skin (basal cell & squamous cell carcinomas, mycosis fungoides – Sezary syndrome). The guideline provides recommendations on pathology reports, operative reports, laboratory reports, and imaging reports. Please note that the sub-sections within this set were published and revised at varying dates, and that the publication year referenced here refers only to the date that the guideline set was accessed online.

Skin Cancer

Year: 2014
AGREE II score: Unavailable
Developer organization: BC Cancer Agency
This guideline set provides recommendations on the management of skin cancers including melanoma and non-melanoma. Topics of discussion include potential precursors, surveillance and early detection, diagnosis and staging, and management. Additionally, referral information and management policies are discussed. Please note that the sub-sections within this set were published and revised at varying dates, and that the publication year referenced here refers only to the date that the guideline set was accessed online.

Musculoskeletal & Sarcoma Cancer

Year: 2014
AGREE II score: Unavailable
Developer organization: BC Cancer Agency
This guideline set provides recommendations on the management of musculoskeletal cancers including bone cancer and soft tissue sarcoma. Topics of discussion include prevention, diagnosis and staging, management, and follow-up. Additionally, diagnostic pathology, and treatment through chemotherapy, radiotherapy, and surgery are discussed. Please note that the sub-sections within this set were published and revised at varying dates, and that the publication year referenced here refers only to the date that the guideline set was accessed online.

Lung Cancer

Year: 2014
AGREE II score: Unavailable
Developer organization: BC Cancer Agency
This guideline set provides recommendations on the management of lung cancers including mesothelioma and thymomas. Topics of discussion include prevention, early detection, diagnosis and staging, and management. Please note that the sub-sections within this set were published and revised at varying dates, and that the publication year referenced here refers only to the date that the guideline set was accessed online.

Breast Cancer

Year: 2014
AGREE II score: Unavailable
Developer organization: BC Cancer Agency
This is a clinical practice guideline for breast cancer. The guideline examines demographics and risk factors, prevention, screening and early detection, diagnosis, staging, management, and follow-up. Other important aspects explored in the guideline include: upper extremity rehab after axillary dissection, exercise for cardiovascular fitness, as well as benefits, risks, and costs. Please note that the sub-sections within this guideline were published and revised at varying dates, and that the publication year referenced here refers only to the date that the guideline was accessed online.

Early Detection of Cancer in AYAs

Year: 2014
AGREE II score: Available
Developer organization: Cancer Council Australia
This is a clinical practice guideline for the early detection of common cancers in adolescents and young adults aged between 15 and 24 years of age. The cancers covered include leukemia, lymphoma, brain tumours, soft tissue sarcoma, testicular cancer, thyroid cancer, and melanoma. The guideline discusses common signs and symptoms and provides recommendations on clinical assessment and referral. "Youth-friendly" communication between practitioner and patient is also discussed, and links for patient and practitioner resources are provided.

International Society of Geriatric Oncology Consensus on Geriatric Assessment in Older Patients With Cancer

Year: 2014
AGREE II score: Available
Developer organization: International Society of Geriatric Oncology (SIOG)
This guideline provides recommendations on geriatric assessment (GA) in older oncology patients. Topics of discussion include the use of GA to predict oncology treatment-related complications, the association between GA findings and overall survival; (OA), and the impact of GA findings on oncology treatment decisions. The composition of and key domains within GA are reviewed, and recommendations are provided on implementing GA in clinical care.

Anal Cancer: ESMO-ESSO-ESTRO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-Up

Year: 2014
AGREE II score: Unavailable
Developer organization: European Society for Medical Oncology
This is a clinical practice guideline for patients diagnosed with or at risk of having anal cancer. The guideline outlines screening and prevention, diagnostic assessment and staging, treatment, and follow-up and surveillance. Special topics of interest include treatment of the elderly and personalized medicine. Management of advanced/metastatic disease is also discussed. Outcomes of interest include survival, recurrence rates and quality of life.

Guidelines on Genetic Evaluation and Management of Lynch Syndrome: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer

Year: 2014
AGREE II score: Unavailable
Developer organization: American College of Gastroenterology
This is a clinical practice guideline for patients at risk for and affected with Lynch syndrome. The guideline examines appropriate provision of genetic testing and management of patients. Important aspects include: ways to assess individuals for the risk of colorectal cancer, tumour testing, algorithms for genetic evaluation of affected and at-risk family members of pedigrees with Lynch syndrome, and the provision of diagnosis and management strategies to health-care providers caring for these patients.

ACG Clinical Guideline: The Diagnosis and Management of Focal Liver Lesions

Year: 2014
AGREE II score: Unavailable
Developer organization: American College of Gastroenterology
A clinical practice guideline for the diagnosis and management of focal liver lesions, including hemangioma, focal nodular hyperplasia, hepatocellular adenoma, and hepatic cysts. The guideline examines diagnosis, including imaging characteristics, and treatment modalities. Outcomes of interest include a focus on local availability of expertise and resources, and improved 5-year survival through early detection.

Management of Malignant Pleural Effusion

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for patients with suspected or diagnosed malignant pleural effusions. The guideline examines diagnosis and treatment for symptomatic and asymptomatic patients, including therapeutic thoracentesis. Outcomes of interest include improved relief of dyspnea and reduced hospital stay time.

Hepatocellular Carcinoma

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients with hepatocellular carcinoma. The guideline provides recommendations on diagnostic assessment, staging, and management. Treatment options including resection, liver transplantation, radiofrequency ablation (RFA), percutaneous ethanol injection (PEI), transarterial chemo-embolization (TACE), transarterial radioembolization (TARE), sorafenib, and stereotactic body radiotherapy (SBRT) are reviewed.

Adenocarcinoma of the Pancreas

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients over 18 years of age with pancreatic cancer. The guideline reviews diagnostic work-up, staging, and treatment options for both potentially curable and unresectable pancreatic cancer. Comparisons are made between FOLFIRINOX and gemcitabine chemotherapy regimes. Outcomes of interest include survival, adverse events, and response rate.

Provincial Esophageal and Gastro-Esophageal Junction Cancer Treatment Guidelines

Year: 2014
AGREE II score: Unavailable
Developer organization: Saskatchewan Cancer Agency
A clinical practice guideline for patients with esophageal cancer and gastro-esophageal junction cancer. The guideline examines diagnostic assessment and proposed treatment based on cancer staging, with a focus on chemoradiation and surgical therapies. Outcomes of interest include improved recommendations for patients with good and poor performance.

Sentinel Lymph Node Biopsy in Vulvar Cancer

Year: 2014
AGREE II score: Available
Developer organization: Cancer Care Ontario
This clinical practice guideline provides recommendations in relation to sentinel lymph node biopsy (SLNB) in vulvar cancer. The guideline seeks to determine whether SLNB can safely and effectively identify women with node-negative, early-stage vulvar cancer and can be used as an alternative to inguinofemoral lymph node dissection (IFLD). Additionally, the guideline provides guidance with respect to the appropriate techniques and procedures in SLNB for women with early-stage vulvar cancer. These include: the selection of appropriate patients; determining the appropriate technique, and management of patients with positive sentinel lymph nodes.

2014 Guidelines on Renal Cell Carcinoma

Year: 2014
AGREE II score: Available
Developer organization: European Association of Urology
A clinical practice guideline for the management of renal cell carcinoma. The guideline examines the diagnosis, staging, treatment, and follow-up of renal cell carcinoma, including updates on histology and localized disease treatment through venous thrombus. Outcomes of interest include improved management through nephron-sparing surgery and improved surveillance for small renal masses.

2014 Guidelines on Penile Cancer

Year: 2014
AGREE II score: Available
Developer organization: European Association of Urology
A clinical practice guideline for the management of penile cancers in adult male patients, focusing primarily on penile squamous cell carcinoma. The guideline examines the full continuum of cancer care for penile cancer patients, and provides a variety of treatment options based on staging and diagnosis. Outcomes of interest include improved functional and cosmetic treatment and reduced nodal recurrence.

Guidelines on non-muscle-invasive bladder cancer (TaT1 and CIS)

Year: 2014
AGREE II score: Available
Developer organization: European Association of Urology
A clinical practice guideline for non-muscle-invasive bladder cancer patients with Ta, T1, and CIS grade tumours. The guideline examines diagnosis and treatment with a particular focus on adjuvant treatment options. Outcomes of interest include reduced recurrence with smoking cessation, and improved early detection through imaging.

Management of Lung Cancer: A National Clinical Guideline

Year: 2014
AGREE II score: Available
Developer organization: Scottish Intercollegiate Guidelines Network
A clinical practice guideline for the management of patients with small cell and non-small cell lung cancer. The guideline examines the continuum of care for lung cancer, including the importance of smoking cessation, staging investigations, surgery as a curative option, radiotherapy recommendations, and palliative care considerations. Outcomes of interest include survival benefits with non-surgical management, reduced side effects in second line therapies, and increased staging specificity.

Clinical Practice Guidelines for the Treatment and Management of Endometrial Cancer

Year: 2014
AGREE II score: Available
Developer organization: Cancer Council Australia
This is a clinical practice guideline for patients with apparent early stage endometrial cancer at the time of diagnosis, that may have low or high risk features. The guideline examines pre-operative investigations, surgery techniques, and adjuvant treatment including radiotherapy and chemotherapy, with recommendations taking risk into consideration. The use of multidisciplinary team management is also discussed. Outcomes of interest include treatment risks, complications, and survival rates. This guideline is wiki-based and is constantly updated as new evidence arises - this review pertains to the guideline as of July 11, 2014

ACR Appropriateness Criteria Diffuse Large B-Cell Lymphoma

Year: 2014
AGREE II score: Available
Developer organization: American College of Radiology
This is a clinical practice guideline for the management of patients with diffuse large B-cell lymphoma (DLBCL). The guideline provides recommendations for diagnosis, staging, and treatment, and the appropriateness of different techniques is examined for different clinical situations. Outcomes of interest include overall survival, event-free survival, progression-free survival, failure-free survival, adverse events, and toxicity.

Update of the European Guidelines for Basal Cell Carcinoma Management

Year: 2014
AGREE II score: Unavailable
Developer organization: European Dermatology Forum
This is a clinical practice guideline for patients diagnosed with or suspected of having basal cell carcinoma. The guideline reviews prognosis and risk factors, diagnosis, treatment, follow-up care, and prevention. Outcomes of interest include cure rate, recurrence, cost-effectiveness, and response rate.

Screening, Assessment, and Management of Fatigue in Adult Survivors of Cancer: An American Society of Clinical Oncology Clinical Practice Guideline Adaptation

Year: 2014
AGREE II score: Available
Developer organization: American Society of Clinical Oncology
A clinical practice guideline for the treatment of fatigue in adult cancer survivors. The guideline examines the assessment and treatment of fatigue in cancer survivors, particularly through psychosocial interventions and physical activity. Outcomes of interest include improved fatigue relief and patient mood.

Guidelines on Prostate Cancer

Year: 2014
AGREE II score: Available
Developer organization: European Association of Urology
A clinical practice guideline for prostate cancer patients, particularly older men. The guideline examines diagnosis, staging, treatment and follow up, primarily for locally advanced and metastatic cancers. Outcomes of interest include improved functional outcomes and improvements in deferred treatment.

Guidelines for the First Line Management of Classical Hodgkin Lymphoma

Year: 2014
AGREE II score: Unavailable
Developer organization: British Committee for Standards in Haematology
This clinical practice guideline reviews pre-treatment evaluation, management, follow-up, late effects, and survivorship of patients with classical Hodgkin lymphoma (HL). The guideline reviews management of early and advanced stage HL, as well as HL in pregnancy and in elderly patients. Chemotherapy and radiotherapy are discussed as treatment options, and PET/CT imaging is reviewed as a pre- and post-treatment assessment tool. Outcomes of interest include therapy related efficacy and toxicity, predictive value of assessment tools, survival, morbidity, and mortality.

Lymphoma, Chronic Leukemia, Myeloma Cancer

Year: 2014
AGREE II score: Unavailable
Developer organization: BC Cancer Agency
This guideline set provides recommendations on the management of hematologic cancers including amyloidosis, chronic leukemia, Hodgkin's lymphoma and other forms of lymphoma, monoclonal gammopathy of unknown significance, multiple myeloma, and solitary plasmacytoma. Topics of discussion include diagnosis and staging, management, and follow-up. Additionally, biopsy procedures, protein studies, and immunizations for this population are discussed. Please note that the sub-sections within this set were published and revised at varying dates, and that the publication year referenced here refers only to the date that the guideline set was accessed online.

Gastrointestinal Cancer

Year: 2014
AGREE II score: Unavailable
Developer organization: BC Cancer Agency
This guideline set provides recommendations on gastrointestinal cancer, with sub-sections discussing the following tumour sites: anus, bile duct, colon, esophageal and esophagogastric junction, gallbladder, liver, neuroendocrine tumours, lymphoma, gastro-intestinal stromal tumours (GIST), pancreas, rectum, small bowel, and stomach. Important aspects discussed in the guideline include: screening, diagnostic and staging, surgical therapy, staging, follow up and surveillance, and considers different treatment options. Please note that the sub-sections within this set were published and revised at varying dates, and that the publication year referenced here refers only to the date that the guideline set was accessed online.

Endometrial Cancer: A Review and Current Management Strategies: Part I

Year: 2014
AGREE II score: Unavailable
Developer organization: Society of Gynecologic Oncology
This is a clinical practice guideline for patients diagnosed with or suspected of having endometrial cancer. The guideline reviews diagnostic evaluation, staging, and surgical management. The use and value of various surgical approaches including hysterectomy, lymphadenectomy, and cytoreductive surgery are discussed. Outcomes of interest include sensitivity, specificity, and positive predictive value of staging procedures, postoperative morbidity, and survival rates.

Colon Cancer: Diagnosis, Treatment and Follow-Up

Year: 2014
AGREE II score: Available
Developer organization: Belgian Health Care Knowledge Centre
This is a clinical practice guideline for adult patients diagnosed with or suspected of having colon cancer. The guideline provides recommendations on diagnostic assessment and staging, pathology, treatment, and follow-up care. The use of KRAS mutational analysis and BRAF are reviewed, and N-RAS and MSI are discussed as predictors of treatment effectiveness. Comparisons are made between chemotherapy regimes, surgical techniques, and recovery programs. Outcomes of interest include sensitivity and specificity of diagnostic tests, survival (progression-free, overall), surgical outcomes (mortality, complications, readmissions, hospital stay, peri-procedural morality), and quality of life.

Advanced Breast Cancer (Update): Diagnosis and Treatment

Year: 2014
AGREE II score: Available
Developer organization: National Institute for Health and Care Excellence
A clinical practice guideline for patients with advanced breast cancer. The guideline examines diagnosis and treatment, focusing on systemic therapies, and provides patient-centred recommendations. Outcomes of interest include reductions in skeletal-related events and optimized drug sequencing.

Oncologic Emergencies: A Guide for Family Physicians

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for the treatment of oncological emergencies related to cancer or anticancer therapy for family physicians. The guideline examines complications associated with cancer and cancer therapy, including diagnosis and treatment. Outcomes of interest include improved patient safety and reduced unnecessary treatment.

Care of the Pediatric Patient With a Brain Tumour

Year: 2014
AGREE II score: Unavailable
Developer organization: American Association of Neuroscience Nurses
A clinical practice guideline for pediatric brain tumour patients, specifically for nursing activities. The guideline examines management of brain tumour diagnosis and treatment, including symptom management and supportive care. Outcomes of interest include improved nursing surveillance of neurological and hereditary cognitive symptoms.

Genital Tract Cancers in Females: Ovarian, Fallopian Tube, and Primary Peritoneal Cancers

Year: 2014
AGREE II score: Unavailable
Developer organization: Guidelines and Protocols Advisory Committee
This is a clinical practice guideline for female patients aged 19 and older. The guideline provides recommendations on screening, diagnosis, treatment, and follow-up care of ovarian, fallopian tube, and primary peritoneal cancers. Prevention and risk reduction strategies are also reviewed.

Clinical Indications for Computed Tomographic Colonography: European Society of Gastrointestinal Endoscopy (ESGE) and European Society of Gastrointestinal and Abdominal Radiology (ESGAR) Guideline

Year: 2014
AGREE II score: Available
Developer organization: European Society of Gastrointestinal Endoscopy (ESGE)
A clinical practice guideline for the use of computed tomographic colonography in patients with colorectal cancer. The guideline examines colorectal surveillance and polypectomy and their feasibility for patients with symptoms of colorectal cancers. Outcomes of interest include improvements over standard barium enemas and increased diagnostic sensitivity.

Neoadjuvant Treatment of Primary Breast Cancer

Year: 2014
AGREE II score: Unavailable
Developer organization: Eastern Health
This is a clinical practice guideline for patients with a pathological confirmed diagnosis of breast cancer. The guideline reviews diagnostic assessment, staging, and neoadjuvant treatment regimes depending on whether breast cancer is operable or inoperable. The guideline also discusses challenges involved with neoadjuvant therapy.

Italian Consensus Guidelines for the Diagnostic Work-up and Follow-up of Cystic Pancreatic Neoplasms

Year: 2014
AGREE II score: Available
Developer organization: Italian Association of Hospital Gastroenterologists and Endoscopists, AIGO
This clinical practice guideline provides recommendations on diagnostic assessment and follow-up for patients with cystic pancreatic neoplasms. Topics covered include indications for work-up, laboratory tests, serum markers, imaging and nuclear medicine, ultrasound/endoscopy, laboratory markers in cystic fluid, and pathology. Outcomes of interest include sensitivity and specificity, positive and negative predictive values, and accuracy of diagnostic/assessment procedures.

Central Venous Catheter-related Infections in Hematology and Oncology: 2012 Updated Guidelines on Diagnosis, Management and Prevention by the Infectious Diseases Working Party of the German Society of Hematology and Medical Oncology

Year: 2014
AGREE II score: Unavailable
Developer organization: German Society of Hematology and Oncology (DGHO)
This is a clinical practice guideline on catheter-related infections (CRIs) in patients with malignancies. The guideline provides recommendations on diagnosis, management, and prevention of CRI in cancer patients. Topics discussed in the guideline include: risk factors for CRI, surveillance, the selection of catheters and sites, as well as a section on related unresolved issues requiring further study.

Minimally Invasive Follicular Thyroid Cancer (MIFTC) – A Consensus Report of the European Society of Endocrine Surgeons (ESES)

Year: 2014
AGREE II score: Available
Developer organization: European Society of Endocrine Surgeons (ESES)
This is a clinical practice guideline for minimally invasive thyroid carcinoma (MIFTC). The guideline considers recommendations in the management of patients with MIFTC. Topics of consideration include: MIFTC definition, specimen processing, characteristics, diagnosis, prognoses, and therapy. Also of interest in the guideline is the distinction between MIFTC and widely invasive follicular thyroid carcinoma (WIFTC).

Primary Unknown Cancer

Year: 2014
AGREE II score: Unavailable
Developer organization: BC Cancer Agency
This guideline set provides recommendations on the management of metastatic cancer of unknown primary site including primarily adenocarcinomas and undifferentiated carcinomas. Topics of discussion include diagnosis and staging, management, and follow-up. Additionally, diagnostic pathology and special patient clusters are discussed. Please note that the sub-sections within this set were published and revised at varying dates, and that the publication year referenced here refers only to the date that the guideline set was accessed online.

Neuro-Oncology Cancer

Year: 2014
AGREE II score: Unavailable
Developer organization: BC Cancer Agency
This guideline set provides recommendations on the management of neurological cancers including five primary subgroups: astrocytoma, oligodendroglioma, ependymoma, meningioma, and pituitary adenoma. Topics of discussion include prevention, diagnosis and staging, management, and follow-up. Additionally, the use of corticosteroids and anticonvulsants are discussed. Please note that the sub-sections within this set were published and revised at varying dates, and that the publication year referenced here refers only to the date that the guideline set was accessed online.

Genitourinary Cancer

Year: 2014
AGREE II score: Unavailable
Developer organization: BC Cancer Agency
This guideline set provides recommendations on genitourinary cancer, with sub-sections on: prostate, bladder, kidney, testis, penis, scrotum, renal pelvis and ureter, and female urethra. Important aspects discussed in the guideline include: predisposing factors and prevention, screening and early detection, diagnosis, staging, and management. Please note that the sub-sections within this set were published and revised at varying dates, and that the publication year referenced here refers only to the date that the guideline set was accessed online.

Comprehensive Cervical Cancer Control: A Guide to Essential Practice – 2nd Ed

Year: 2014
AGREE II score: Unavailable
Developer organization: World Health Organization
This clinical practice guideline discusses cervical cancer control including: cervical cancer prevention and control programmes; community mobilization, education and counselling; HPV vaccination; screening and treatment of cervical pre-cancer; diagnosis and treatment of invasive cervical cancer; and palliative care. Treatment options for special populations including women who are pregnant and women living with HIV are also reviewed.

Management of Primary Cutaneous Squamous Cell Carcinoma

Year: 2014
AGREE II score: Available
Developer organization: Scottish Intercollegiate Guidelines Network
This is a clinical practice guideline for patients over 18 years of age with primary invasive SCC cutaneous squamous cell carcinoma. The guideline reviews risk factors, staging, therapeutic interventions, and follow-up care. Outcomes of interest include prognostic factors, survival (five-year overall and recurrence free), local control, recurrence rate (regional and distant), nodal metastases, effectiveness of treatment, and adverse events.

Uveal Melanoma

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients with malignant uveal melanoma. The guideline reviews diagnosis and work-up, primary management, adjuvant therapy, management of patients with metastatic disease, and management of high risk patients. Follow-up care is also discussed. Outcomes of interest include efficacy of treatments and imaging modalities.

Guidelines on the Diagnosis and Management of Waldenström Macroglobulinaemia

Year: 2014
AGREE II score: Unavailable
Developer organization: British Committee for Standards in Haematology
A clinical practice guideline for patients with, or being screened for, Waldenström macroglobulinaemia. The guideline examines management, including consistent monitoring of immunoglobulin and biological therapy with rituximab-containing regimens. Outcomes of interest increased treatment uniformity and solidified indications for introduction of treatment.

Management of Patients With Early Esophageal Cancer, Dysplastic and Non-Dysplastic Barrett’s Esophagus

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for the management of patients with early esophageal cancer, dysplastic and non-dysplastic Barrett's esophagus. This guideline examines treatment options and considers in what clinical situations endoscopic therapy is the most appropriate treatment. Treatment options explored and discussed include: endoscopic mucosal resection, radiofrequency ablation, photodynamic therapy, argon plasma coagulation, and multipolar electrocoagulation.

Genital Tract Cancers in Females: Human Papillomavirus Related Cancers (Cervical, Vaginal & Vulvar)

Year: 2014
AGREE II score: Unavailable
Developer organization: Guidelines and Protocols Advisory Committee
This is a clinical practice guideline for female patients aged 9 and above. The guideline provides recommendations on screening, diagnosis, treatment, and follow-up care of human papillomavirus (HPV) related cancers including cervical, vaginal, and vulvar. Special topics of interest include an overview of HPV vaccines and a discussion on controversies in care, including screening intervals and age to stop screening.

Self-expandable Metal Stents for Obstructing Colonic and Extracolonic Cancer: European Society of Gastrointestinal Endoscopy (ESGE) Guideline

Year: 2014
AGREE II score: Available
Developer organization: European Society of Gastrointestinal Endoscopy
A clinical practice guideline for patients with malignant colonic obstruction and colorectal cancer. The guideline examines colonic self-expandable metal stent placement in prophylactic, elective, emergency, and palliative surgeries. Outcomes of interest include reduced colonic perforation and reduced mortality.

Chronic Lymphocytic Leukemia

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients over 18 years of age with possible chronic lymphocytic leukemia. The guideline reviews the management of chronic lymphocytic leukemia, including diagnosis and prognosis, first-line and second-line treatment options, and follow-up and supportive care. Outcomes of interest include survival (overall and progression-free), toxicity, overall response, and quality of life.

2014 Urothelial Carcinomas of the Upper Urinary Tract

Year: 2014
AGREE II score: Available
Developer organization: European Association of Urology
A clinical practice guideline for the management of upper tract urothelial carcinomas. The guideline examines diagnosis, treatment, and follow-up, with recommendations for treatment based on risk stratification. Outcomes of interest include improved diagnosis to removal time recommendations and post-operative treatments.

Malignant Melanoma S3-Guideline “Diagnosis, Therapy and Follow-up of Melanoma”

Year: 2013
AGREE II score: Unavailable
Developer organization: German Cancer Society (DKG)
This is a clinical practice guideline concerning the diagnosis, therapy and follow-up of melanoma. The guideline examines such treatment options as excision, adjuvant therapy with interferon-alpha, and lymphadenectomy. In addition, new immunotherapies such as the CTLA-4 antibody ipilimumab are considered, and follow-up procedures are discussed.

A Hematology Consensus Agreement on Antifungal Strategies for Neutropenic Patients With Hematological Malignancies and Stem Cell Transplant Recipients

Year: 2013
AGREE II score: Unavailable
Developer organization: Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA)
A clinical practice guideline for neutropenic patients with hematological malignancies and stem cell transplant recipients. The guideline examines antifungal therapy, including pre-emptive and targeted management. Outcomes of interest include improved treatment definition based on fungal markers and appropriate treatment start points.

European Experts Consensus Statement on Cystic Tumours of the Pancreas

Year: 2013
AGREE II score: Unavailable
Developer organization: European Study Group on Cystic Tumours of the Pancreas
A clinical practice guideline for patients with cystic tumours of the pancreas. The guideline examines the diagnosis and management of pancreatic tumours, including assessment of biopsy and surgical assessment. Outcomes of interest include improved diagnostic imaging and improved follow-up.

Gestational Trophoblastic Disease: ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-up

Year: 2013
AGREE II score: Unavailable
Developer organization: European Society for Medical Oncology
This is a clinical practice guideline for patients diagnosed with or suspected of having gestational trophoblastic disease (GTD). The guideline reviews diagnosis, staging, management of disease, and follow-up care. Treatment options for gestational trophoblastic tumours, placental site trophoblastic tumour/epithelioid trophoblastic tumours, and drug-resistant disease are reviewed. Outcomes of interest include survival, remission rate, toxicity, prognostic factors, and disease relapse.

Fourth European Conference on Infections in Leukaemia (ECIL-4): Guidelines for Diagnosis and Treatment of Human Respiratory Syncytial Virus, Parainfluenza Virus, Metapneumovirus, Rhinovirus, and Coronavirus

Year: 2013
AGREE II score: Unavailable
Developer organization: European Conference on Infections in Leukaemia
A clinical practice guideline for patients with leukemia or undergoing hematopoietic stem cell transplantation. The guideline examines diagnosis and treatment of community-acquired respiratory virus infections, including aerosolized or systemic ribavirin treatment. Outcomes of interest include improved detection through nucleic acid amplification testing and improved screening criteria.

The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: Background and Consensus Recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology

Year: 2013
AGREE II score: Available
Developer organization: American Society for Colposcopy and Cervical Pathology
A clinical practice guideline for patients with, or suspected of having, HPV associated lesions of the lower anogenital tract. The guideline examines appropriate terminology for cancers of the anogenital region and provides a diagnostic and histopathologic nomenclature system for use in clinical settings. Outcomes of interest include clarified margins for squamous cells and lesions in terms of both regional definition and staging.

Recommendations on Screening for Prostate Cancer With the Prostate-specific Antigen Test

Year: 2013
AGREE II score: Available
Developer organization: Canadian Task Force on Preventive Health Care
A clinical practice guideline for men in the general population at risk for prostate cancer. The guideline examines prostate-specific antigen testing with or without digital rectal examination, and when prostate-specific antigen testing is considered a necessary and appropriate screening technique. Outcomes of interest include reduced overdiagnosis and false-positive testing.

Provincial Endometrium Cancer Treatment Guidelines

Year: 2013
AGREE II score: Unavailable
Developer organization: Saskatchewan Cancer Agency
A clinical practice guideline for patients with endometrial cancer. The guideline examines diagnosis and treatment options for pre- and post-menopausal women, with specific focus on the surgical extent of treatment. Outcomes of interest include improved recommendations for laparoscopy and improved accuracy of lymphadenectomy for staging.

The Role of Endoscopy in the Evaluation and Treatment of Patients with Biliary Neoplasia

Year: 2013
AGREE II score: Unavailable
Developer organization: American Society for Gastrointestinal Endoscopy
This is a clinical practice guideline for adult patients with suspected biliary neoplasia. The guideline reviews evaluation and treatment options of biliary neoplasia including cholangiocarcinoma, gallbladder polyps, and adenocarcinoma of the gallbladder. Recommendations are provided for radiologic imaging and endoscopic approaches. Outcomes of interest include sensitivity, specificity of diagnostic procedures, and safety and effectiveness of endoscopic procedures.

British Thoracic Society Guideline for Diagnostic Flexible Bronchoscopy in Adults

Year: 2013
AGREE II score: Available
Developer organization: British Thoracic Society
This is a clinical practice guideline for adult patients undergoing flexible bronchoscopy (FB). The guideline provides recommendations on best practice in FB, with an overview of staff safety, procedure, complications, provision of patient information, and obtaining informed consent. The guideline also discusses the use of FB for diagnosis of lung cancer, interstitial lung disease, and infection, including review of biopsy and sampling technique. Outcomes of interest include test sensitivity, specificity, and diagnostic yield, complications and adverse effects of FB and of drugs used during procedure, and patient satisfaction.

Guidelines for the Management of Mature T-cell and NK-cell Neoplasms (Excluding Cutaneous T-cell Lymphoma)

Year: 2013
AGREE II score: Unavailable
Developer organization: British Committee for Standards in Haematology
This is a clinical practice guideline for patients with mature T-cell and natural killer (NK)-cell neoplasms (excluding cutaneous T-cell lymphoma). Diagnostic assessment, staging, and treatment options are reviewed. The guideline also discusses antimicrobial prophylaxis and central nervous system (CNS) prophylaxis during therapy. Outcomes of interest include survival, response rate, rate of remission, disease progression, predictive value of diagnostic testing, and treatment related toxicity.

Follow-Up Care for Early-Stage Breast Cancer

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for patients who have completed treatment for early-stage breast cancer. The guideline examines surveillance follow-up for potential recurrence, with specific focus on potential complications from previous treatment. Outcomes of interest include improved management of endocrine therapy complications and improved lymphadema management.

Squamous Cell Carcinoma of the Vulva

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients over 18 years of age with squamous cell carcinoma of the vulva. The guideline reviews pre-operative investigations, primary treatment, adjuvant treatment, and follow-up and surveillance, with general and stage-specific recommendations provided. Outcomes of interest include cancer-related death rate, survival (overall and disease-free), progression-free interval, local control, and recurrence rate.

Muscle Invasive and Locally Advanced/Metastatic Bladder Cancer

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients with muscle invasive bladder cancer (i.e., stages T2a/b, T3a/b, T4a and N0-X, M0). The guideline reviews evaluation and staging, treatment, and follow-up care according to stage. Outcomes of interest include survival, recurrence rate, bladder preservation rate, rate of metastasis, and presence of residual disease.

Guidelines on Non-muscle-invasive Bladder Cancer (TaT1 and CIS)

Year: 2013
AGREE II score: Available
Developer organization: European Association of Urology
A clinical practice guideline for non-muscle-invasive bladder cancer patients. The guideline examines diagnosis and treatment, with specific reference to intravesical treatment techniques. Outcomes of interest include improved Bacillus Calmette-Guérin (BCG) immunotherapy protocols and improved early detection.

Establishing the Diagnosis of Lung Cancer: Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines

Year: 2013
AGREE II score: Available
Developer organization: American College of Chest Physicians
A clinical practice guideline for the screening and diagnostic assessment of small cell and non-small cell lung cancer. The guideline examines diagnostic procedures, including transthoracic needle aspiration and sputum cytology, with reference to tumour size, location, and patient risk factors. Outcomes of interest include increased diagnostic accuracy, specifically in malignant pleural effusions.

Provincial Cervical Cancer Treatment Guidelines

Year: 2013
AGREE II score: Unavailable
Developer organization: Saskatchewan Cancer Agency
A clinical practice guideline for patients with a positive diagnosis for cervical cancer. The guideline examines diagnosis and staging, and provides treatment recommendations based on cancer stage. Specific recommendations are also provided for pregnant patients. Outcomes of interest include improved use of adjuvant post-operative radiotherapy based on pathological findings.

Nasopharyngeal Cancer Treatment

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for the management of patients with, or suspected of having, nasopharyngeal cancer. The guideline examines baseline investigation procedures, treatment options with a specific focus on radiotherapy, and follow-up. Outcomes of interest include improved treatment strategies for advanced stage patients, and improved concurrent chemotherapy options.

Cancer of the Uterine Cervix

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients with cancer of the uterine cervix, including squamous, adenocarcinomas, and adenosquamous carcinomas. The guideline reviews evaluation and staging, treatment, and follow-up procedures. Management of recurrent disease is also discussed. Outcomes of interest include survival (overall, disease-free, and progression-free), overall response rate, and toxicity.

2013 Guidelines on Renal Cell Carcinoma

Year: 2013
AGREE II score: Available
Developer organization: European Association of Urology
A clinical practice guideline for the management of renal cell carcinoma. The guideline examines updates existing guidelines on diagnosis, staging, treatment, and follow-up, specifically focusing on improved data assessment. Outcomes of interest include improved evidence for the use of nephron-sparing surgery and increased use of surveillance for elderly patients.

Prostate Cancer

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for men with prostate cancer or suspected prostate cancer. The guideline provides an overview of early diagnostic and screening procedures, management and treatment options, and follow-up care for low-risk, intermediate-risk, and advanced disease. The guideline also reviews bone health and the use of bisphosphonates as treatment for castrate resistant disease. Outcomes of interest include mortality, quality of life, morbidity, treatment complications, and toxicity.

Diagnostic Surgical Pathology in Lung Cancer: Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines

Year: 2013
AGREE II score: Available
Developer organization: American College of Chest Physicians
A clinical practice guideline for the management of small cell and non-small cell lung cancer. The guideline examines treatment options, including chemotherapy and surgical resection, based on pathologic tumour stage and histopathologic features. Outcomes of interest include increased diagnostic accuracy for pleural-based malignancies and improved distinction between primary lung cancers and metastatic lung cancers.

Diagnosis and Treatment of Bronchial Intraepithelial Neoplasia and Early Lung Cancer of the Central Airways: Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines

Year: 2013
AGREE II score: Available
Developer organization: American College of Chest Physicians
This is a clinical practice guideline for patients with suspected or diagnosed bronchial intraepithelial neoplasia (BIN) or early lung cancer of the central airways. Autofluorescence bronchoscopy (AFB) is compared to white light bronchoscopy (WLB) as a diagnostic assessment tool, and treatment options are reviewed including surgical resection and endobronchial treatment with photodynamic therapy (PDT), brachytherapy, cryotherapy, or electrocautery. Outcomes of interest include treatment response, recurrence, and progression rates.

Clinical and Organizational Factors in the Initial Evaluation of Patients With Lung Cancer Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines

Year: 2013
AGREE II score: Available
Developer organization: American College of Chest Physicians
This is a clinical practice guideline for patients with known or suspected lung cancer. The guideline examines initial evaluation through physical examination and function tests, and special considerations are made for distant metastases and paraneoplastic syndromes. Outcomes of interest include improved survival with more efficient timelines and increased treatment team diversity.

Gastric Cancer

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients over the age of 18 with gastric cancer. The guideline discusses diagnostic work-up, staging, and treatment recommendations. Outcomes of interest include survival (overall and five-year progression-free), and side effects of therapy.

Epidemiology and Investigations for Suspected Endometrial Cancer

Year: 2013
AGREE II score: Unavailable
Developer organization: Society of Obstetricians and Gynaecologists of Canada
This is a clinical practice guideline for women with possible endometrial cancer. The guideline reviews the epidemiology of endometrial cancer and provides recommendations on diagnostic workup. Diagnostic procedures include biopsy, hysteroscopy, dilation and curettage, pelvic ultrasound, CT scan, and MRI. Outcomes of interest include accuracy, sensitivity, and specificity of diagnostic tests.

2013 European Thyroid Association Guidelines for Cervical Ultrasound Scan and Ultrasound-Guided Techniques in the Postoperative Management of Patients with Thyroid Cancer

Year: 2013
AGREE II score: Unavailable
Developer organization: European Thyroid Association
This clinical practice guideline examines the use of cervical ultrasound scanning (US) in the postoperative management of patients with differentiated thyroid cancer of follicular origin. Topics of interest include recommendations on US procedure including fine needle aspiration technique, differentiation of benign and pathological US patterns, and indications for cervical ultrasound, US-FNA, and in situ biological marker assessment. New methods for preoperative localization of cervical recurrence and alternatives to surgical treatment of cervical recurrence are also discussed. Outcomes of interest include sensitivity, specificity, predictive value, and accuracy of ultrasound scanning.

Breast Disease and Cancer: Diagnosis

Year: 2013
AGREE II score: Unavailable
Developer organization: Guidelines and Protocols Advisory Committee
This is a clinical practice guideline for women aged 19 or greater. The guideline reviews investigation of breast complaints and/or symptoms, diagnostic assessment stratified by age and risk, and management of common breast diseases. Referral criteria for genetic counselling is also discussed.

Diagnosis and Treatment of Primary Myelodysplastic Syndromes in Adults: Recommendations from the European LeukemiaNet

Year: 2013
AGREE II score: Unavailable
Developer organization: European LeukemiaNet
A clinical practice guideline for adult patients with primary myelodysplastic syndrome. The guideline examines diagnostic workup, risk assessment factors, and treatment options, with a focus on stem cell transplantations. Outcomes of interest include improved transplantation through human leukocyte antigen matching and bone marrow blasts.

European Guidelines for Prevention and Management of Influenza in Hematopoietic Stem Cell Transplantation and Leukemia Patients: Summary of ECIL-4 (2011), on behalf of ECIL, a joint venture of EBMT, EORTC, ICHS, and ELN

Year: 2013
AGREE II score: Unavailable
Developer organization: European Conference on Infections in Leukaemia
A clinical practice guideline for patients with leukemia or hematopoietic stem cell transplantation who are immunocompromised. The guideline examines the prevention and management of influenza in patients at high risk of morbidity and mortality, specifically diagnosis through reverse transcriptase multiplex real-time polymerase chain reaction. Outcomes of interest include clarified vaccination timing and criteria and improved antiviral recommendations for neuraminidase inhibitors.

Breast Cancer in Women: Diagnosis, Treatment and Follow-up

Year: 2013
AGREE II score: Available
Developer organization: Belgian Health Care Knowledge Centre
A clinical practice guideline for female patients with breast cancer. The guideline examines management from diagnosis to treatment, with specific recommendations for multiple diagnoses and supportive treatments. Outcomes of interest include improved psychological outcomes with reduced time to breast reconstruction and improved progression free survival through treatment concurrent bevacizumab and chemotherapy.

Management of the Malignant Colorectal Polyp: ACPGBI Position Statement

Year: 2013
AGREE II score: Unavailable
Developer organization: Association of Coloproctology of Great Britain and Ireland
This is a clinical practice guideline for patients with a malignant polyp. The guideline reviews topics such as colonoscopy and endoscopic technique for the removal of large adenomas, the histopathology of adenomas and polypoid carcinomas, how prognostic indicators influence the risk of residual cancer in the bowel wall or lymph nodes, and the likelihood of recurrence if additional treatment is not taken. As well, the benefits and harms of endoscopic resection are reviewed, and the role of endoscopic and radiological imaging in the assessment and follow up of malignant polyps is discussed. Outcomes of interest include risk of post-surgical morbidity and mortality, risk of recurrence, disease-specific survival, and nodal metastasis.

Esophageal Cancer

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients over 18 years of age with esophageal cancer, including both squamous cell and adenocarcinoma. The guideline provides recommendations on diagnostic work-up, staging, treatment options for potentially curable cancer, and management options for incurable cancer. Outcomes of interest include survival (overall, progression-free, 5-year), morbidity, toxicity, and rate of sudden death.

Anal Canal Cancer

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adults over 18 years of age with squamous cell carcinomas that arise in the anal canal. The guideline discusses diagnostic work-up, staging, and the goals of therapy and recommendations for both potentially curable, locally recurrent, and metastatic cancer of the anal canal. Follow-up care is also reviewed.

The Committee for Revision of the Clinical Practice Guidelines for Hepatocellular Carcinoma

Year: 2013
AGREE II score: Available
Developer organization: Japan Society of Hepatology
This is a clinical practice guideline for patients diagnosed with or at risk of developing hepatocellular carcinoma. The guideline reviews prevention, diagnosis and surveillance, surgery, percutaneous ablation therapy, transcatheter arterial chemoembolization (TACE), chemotherapy, and radiation therapy. Post-treatment surveillance, prevention of recurrence, and treatment of recurrent cancer are also reviewed. Outcomes of interest include survival, recurrence, disease progression, sensitivity, specificity, and predictive values of diagnostic tests, efficacy of surveillance and treatment techniques, surgical complications, and postoperative mortality.

Provincial Colorectal Cancer Treatment Guidelines

Year: 2013
AGREE II score: Unavailable
Developer organization: Saskatchewan Cancer Agency
A clinical practice guideline for patients with colorectal cancer. The guideline examines work up steps, and includes recommendations for resectable and unresectable colon and rectal cancers. Outcomes of interest include high response rates with combination chemotherapy and improved therapies for K-RAS mutated tumours.

Testicular Germ Cell Tumours

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients with testicular germ cell tumours. The guideline reviews diagnostic assessment, staging, management, and follow-up care for both seminoma and nonseminomas. Outcomes of interest include survival (overall, disease free), complete response rate, recurrence rates, and toxicity.

Guideline on the Management of Primary Resistant and Relapsed Classical Hodgkin Lymphoma

Year: 2013
AGREE II score: Unavailable
Developer organization: British Committee for Standards in Haematology
A clinical practice guideline for patients with primary refractory or relapsed Hodgkin lymphoma. The guideline examines the role of salvage therapy and autologous stem cell transplantation in eligible patients. Outcomes of interest include improved relapse confirmation and efficacy of first-line treatments.

The Role of Endoscopy in the Assessment and Treatment of Esophageal Cancer

Year: 2013
AGREE II score: Unavailable
Developer organization: American Society for Gastrointestinal Endoscopy
A clinical practice guideline for the assessment and treatment of esophageal cancer in adult patients. The guideline examines diagnosis and treatment, primarily through endoscopic biopsy and therapy. Outcomes of interest include an increased role for ablative techniques and improved palliation with stent methods.

Practice Parameters for the Management of Rectal Cancer (Revised)

Year: 2013
AGREE II score: Unavailable
Developer organization: American Society of Colon and Rectal Surgeons
A clinical practice guideline for the management of colorectal carcinoma. The guideline examines preoperative assessment, staging, surgical techniques, and operative considerations. Outcomes of interest include improved surgical management and reduced recurrence rate.

Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors

Year: 2013
AGREE II score: Available
Developer organization: College of American Pathologists
This is a clinical practice guideline for patients with a diagnosis of non–small cell lung cancer (NSCLC). The guideline examines the molecular analysis of lung cancers that are required to guide epidermal growth factor receptor (EGFR)- and anaplastic lymphoma kinase (ALK)-directed therapies. The guideline provides recommendations on which patients and samples should be tested, and when and how testing should be performed. Outcomes of interest include response rate, disease control rate, time to disease progression, survival (progression free and median), and sensitivity, specificity, positive predictive value, and negative predictive value of tests for EGFR and ALK status or treatment response.

Provincial Gestational Trophoblastic Neoplasia

Year: 2013
AGREE II score: Unavailable
Developer organization: Saskatchewan Cancer Agency
A clinical practice guideline for adult patients with gestational trophoblastic neoplasia including invasive mole, gestational choriocarcinoma, and placental site trophoblastic tumours. The guideline examines management, including concurrent diagnoses and chemotherapy recommendations. Outcomes of interest include reduced congenital malformations in future pregnancies, and improved response rates in maintenance chemotherapy.

Multiple Myeloma

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for the management of multiple myeloma in adult patients. The guideline examines diagnosis and treatment for multiple myeloma, monoclonal gammopathy, smoldering myeloma, and amyloidosis, including prognostic criteria. Outcomes of interest include improved survival outcomes through triple drug based induction regimens and improved dose reduction options for elderly patients.

Lymphoma

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients over 18 years of age with lymphoma. The guideline examines diagnostic assessment and staging procedures as well as treatment and management options. Follow-up and supportive care are also reviewed. Outcomes of interest include response rate (complete and overall), survival (progression-free and overall), time to disease progression, remission duration, freedom from treatment failure, impact of treatment on fertility, and toxicity from treatment.

Common Breast Problems

Year: 2013
AGREE II score: Unavailable
Developer organization: University of Michigan Health System
This is a clinical practice guideline for adults aged 18 and over. The guideline reviews appropriate management and referral of patients presenting with common breast problems, including palpable mass or asymmetric thickening/nodularity on clinical exam, inflammation and other skin changes, breast pain with negative physical exam, and nipple discharge without abnormal exam findings. Management of special populations including pregnant women, men, and patients with augmented breasts, is also discussed. Outcomes of interest include sensitivity, specificity, and positive predictive value of diagnostic tests, and incidence of breast cancer.

Guidelines on Primary Urethral Carcinoma

Year: 2013
AGREE II score: Available
Developer organization: European Association of Urology
This is a clinical practice guideline for patients with, or suspected of having, primary urethral carcinoma. The guideline reviews diagnostic assessment, staging, and treatment. Treatment options include penile-preserving and urethral-sparing surgery, urethrectomy, radiotherapy, cisplatinum-based chemotherapy, chemoradiotherapy, transurethral resection (TUR), Bacille-Calmette-Guérin (BCG), and cystoprostatectomy with extended pelvic lymphadenectomy. Outcomes of interest include survival, sensitivity of diagnostic tests, local cure rate, local recurrence rate, and local tumour control rate.

Guidelines on Urothelial Carcinomas of the Upper Urinary Tract

Year: 2013
AGREE II score: Unavailable
Developer organization: European Association of Urology
This is a clinical practice guideline for patients with, or suspected of having, upper urinary tract urothelial carcinomas (UTUCs). The guideline reviews diagnostic assessment, staging, treatment, and follow-up. Treatment recommendations are provided based on whether the disease is localized or advanced, and include radical nephroureterectomy, conservative surgery, adjuvant topical agents, chemotherapy, and radiotherapy. Outcomes of interest include risk factors, sensitivity and specificity of diagnostic tests, survival (recurrence-free, disease-free, and overall), disease progression, morbidity, and mortality.

Guidelines on muscle-invasive and metastatic bladder cancer

Year: 2013
AGREE II score: Available
Developer organization: European Association of Urology
A clinical practice guideline for muscle-invasive and metastatic bladder cancer patients. The guideline examines management stages including diagnosis, staging, treatment, and follow up. Outcomes of interest include optimised treatment options for elderly patients and improved survival outcomes with pre-surgical neoadjuvant radiotherapy.

Special Treatment Issues in Non-small Cell Lung Cancer: Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines

Year: 2013
AGREE II score: Available
Developer organization: American College of Chest Physicians
This is a clinical practice guideline for patients with unique forms of NSCLC that require special consideration, including patients with Pancoast tumors, T4 N0,1 M0 central tumours, chest wall involvement, additional pulmonary tumour nodules, synchronous and metachronous second primary lung cancers (SPLCs), multifocal lung cancer (MFLC), and solitary metastases. Diagnostic and staging procedures are reviewed and recommendations are made for treatment options including surgical resection, chemotherapy, and radiotherapy. Outcomes of interest include 5-year survival, mortality, accuracy of treatment procedures, complications, mortality, and cost-effectiveness.

Evaluation of Individuals With Pulmonary Nodules: When Is It Lung Cancer? Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines

Year: 2013
AGREE II score: Available
Developer organization: American College of Chest Physicians
A clinical practice guideline for the diagnosis and treatment of patients with solid and nonsolid pulmonary nodules. The guideline examines assessment through imaging, primarily chest radiography and CT scanning, as well as non-surgical biopsy, in order to determine malignancy. Treatment options are considered through the lenses of patient preferences and risk factors, and recommendations are made for surgical resection and systemic therapy. Outcomes of interest include improved diagnoses of malignancies and reductions in unnecessary surgery.

Screening High-Risk Populations for Lung Cancer

Year: 2013
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline on the screening of high-risk patients for lung cancer using LDCT scanning. Risk factors are reviewed and recommendations are provided for duration and interval of screening. The guideline also discusses positive results and appropriate follow-up procedures. Outcomes of interest include effectiveness of screening, false positive rate, complication rate, and risk of death from radiation exposure.

Management of Gastric Cancer in Asia: Resource-Stratified Guidelines

Year: 2013
AGREE II score: Unavailable
Developer organization: Asian Oncology Summit
A clinical practice guideline for patients with gastric cancers. The guideline examines diagnosis and management, including regional and resource-based recommendations. Outcomes of interest include increased HER2 testing and increased post-operative chemotherapy for palliative patients.

Recommendations for Breast Cancer Surveillance for Female Survivors of Childhood, Adolescent, and Young Adult Cancer Given Chest Radiation

Year: 2013
AGREE II score: Available
Developer organization: International Late Effects of Childhood Cancer Guideline Harmonization Group
This is a clinical practice guideline for breast cancer surveillance for female survivors of childhood, adolescent, and young adult (CAYA) cancer given chest radiation. The guideline examines the risk survivors of CAYA cancer of premature morbidity and mortality due to previous cancer treatment. Outcomes of interest include surveillance, detection, and follow-up.

Early Stage Rectal Cancer

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients over 18 years of age with early stage rectal cancer. The guideline reviews diagnostic work-up, staging, and treatment options including surgical resection and chemotherapy.

Early Stage Colon Cancer

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adults over 18 years of age with early stage colon cancer. The guideline provides recommendations on diagnostic work-up, staging, and treatment including a review of recommended chemotherapy regimes.

Patient Information Ahead of Thyroid Surgery

Year: 2013
AGREE II score: Unavailable
Developer organization: French Otorhinolaryngology - Head and Neck Surgery Society (SFORL)
A clinical practice guideline for patients preparing to undergo thyroid surgery. The guideline examines best practices for informing patients of relevant surgical information, including potential risks and complications. Outcomes of interest include mandatory thresholds for informed consent and effective communication methods.

Cholangiocarcinoma and Gallbladder Cancer

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for patients with biliary tract cancer. The guideline examines management, with specific focus on surgical resection for potentially resectable disease and palliative radiotherapy for unresectable disease. Outcomes of interest include improved recommendations for establishing resectability and reductions in endoscopic retrograde cholangiopancreatogram.

Validating Whole Slide Imaging for Diagnostic Purposes in Pathology: Guideline from the College of American Pathologists Pathology and Laboratory Quality Center

Year: 2013
AGREE II score: Available
Developer organization: College of American Pathologists
This clinical practice guideline provides recommendations on validation requirements for whole slide imaging (WSI) systems to be used for diagnostic purposes in pathology. Recommendations include those on sample size, revalidation, washout period, documenting the validation process, and pathologist training. Outcomes of interest include correlation between WSI and glass slides with respect to accuracy, concordance, average diagnostic certainty, sensitivity, and specificity, in the context of validation requirements.

Guidelines for Breast, Cervical and Colorectal Cancer Screening

Year: 2013
AGREE II score: Unavailable
Developer organization: CancerCare Manitoba
This guideline provides screening recommendations for breast, cervical, and colorectal cancer, based on age and risk factors. Management of test results including mammography, cytology, occult blood test (FOBT) and colonoscopy are discussed, and potential benefits and harms are reviewed. Other testing procedures include ultrasound, stereotactic core biopsy, colposcopy, endocervical curettage, endometrial biopsy, flexible sigmoidoscopy, and colonoscopy.

Thyroid Nodules and Differentiated Thyroid Cancer: Update on the Brazilian Consensus

Year: 2013
AGREE II score: Unavailable
Developer organization: Sociedade Brasileira de Endocrinologia e Metabologia
A clinical practice guideline for patients with thyroid nodules and at risk for thyroid cancer. The guideline examines diagnosis for normal and abnormal thyroid-stimulating hormone tests, and treatment including surgical options. Outcomes of interest include reductions in unnecessary procedures and improved recommendations for pregnant patients.

Guidelines for the Management of Malignant Melanoma

Year: 2013
AGREE II score: Unavailable
Developer organization: Cancer Care Nova Scotia
A clinical practice guideline for patients with malignant melanoma. The guideline examines management from diagnosis to follow-up, including referral processes, recommendations for pregnant patients, and supportive care. Outcomes of interest include improved recommendations for the timing and efficacy of sentinel lymph node biopsy, which is generally recommended as a first-line staging tool.

Small Cell and Non-Small Cell Lung Cancer: Diagnosis, Treatment and Follow-up

Year: 2013
AGREE II score: Available
Developer organization: Belgian Health Care Knowledge Centre
A clinical practice guideline for patients with small cell and non-small cell lung cancer. The guideline examines lung cancer management from diagnosis to follow up, including considerations of tumour and organ risks. Outcomes of interest include increased treatment effectiveness through concurrent chemotherapy and improved post-operative management recommendations.

Provincial Vulva Cancer Treatment Guidelines

Year: 2013
AGREE II score: Unavailable
Developer organization: Saskatchewan Cancer Agency
A clinical practice guideline for adult patients with squamous cell carcinoma of the vulva. The guideline examines management of vulvar cancer based on staging, and follow-up protocols. Outcomes of interest include endorsement of sentinel lymph node biopsy as a standard of care and improved referral recommendations.

Guidelines for the Diagnosis and Management of Multiple Myeloma 2013

Year: 2013
AGREE II score: Unavailable
Developer organization: British Committee for Standards in Haematology
This clinical practice guideline discusses diagnosis and management and treatment of patients with suspected or confirmed multiple myeloma. Diagnostic procedures are recommended and treatment options outlined, including chemotherapy, induction therapy, high-dose therapy and autologous stem cell transplantation (ASCT), and allogeneic stem cell transplantation (AlloSCT). The guideline also discusses maintenance therapy and supportive interventions for common complications resulting from myeloma or its treatment. Outcomes of interest include treatment response rate, survival, toxicity, quality of life, and treatment-related mortality.

Preoperative and Pretreatment Investigations for Malignant Melanoma

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients 18 years of age or older with malignant melanoma. The guideline reviews clinical presentation and preliminary work-up for malignant melanoma as well as additional work-up depending on stage. Outcomes of interest include cost-effectiveness, and specificity and sensitivity of diagnostic procedures.

Biopsy of a Suspicious Pigmented Lesion

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for patients presenting with a mole or lesion that is suspicious for melanoma. The guideline examines biopsy techniques and diagnostic elements. Outcomes of interest include reducing misdiagnosis and testing inaccuracy.

The Society of Thoracic Surgeons Guidelines on the Diagnosis and Staging of Patients with Esophageal Cancer

Year: 2013
AGREE II score: Available
Developer organization: Society of Thoracic Surgeons
This clinical practice guideline reviews the diagnosis and staging of esophageal cancer in adult patients. Procedures including flexible endoscopy with biopsy, CT, PET, endoscopic ultrasonography (EUS), Endoscopic mucosal resection (EMR), and laparoscopy are discussed. Outcomes of interest include sensitivity, specificity, and accuracy of diagnostic procedures.

Recommendations for Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Update

Year: 2013
AGREE II score: Unavailable
Developer organization: American Society of Clinical Oncology
A clinical practice guideline for human epidermal growth factor receptor 2 testing in breast cancer. The guideline examines testing and results follow up for oncologists and pathologists in the United States. Outcomes of interest include optimal performance and reporting of assays, and improved education for providers.

2013 Guidelines on Prostate Cancer

Year: 2013
AGREE II score: Available
Developer organization: European Association of Urology
A clinical practice guideline for the management of prostate cancer in adult males. The guideline examines the screening, diagnosis, treatment, and palliative options for prostate cancer patients, with reference to multiple options following failed curative intent treatments. Outcomes of interest include improved screening to rule out radical treatment and treatment deferral.

Management of Epithelial Ovarian Cancer: A National Clinical Guideline

Year: 2013
AGREE II score: Available
Developer organization: Scottish Intercollegiate Guidelines Network
This is a clinical practice guideline for patients diagnosed with or at risk of developing epithelial ovarian cancer. The guideline reviews risk factors and provides recommendations on screening, diagnosis, surgical management, chemotherapy, and follow-up care. Special topics of consideration include the role of prophylactic salpingo-oophorectomy in screening, and management of malignant bowel obstruction in relapsed disease. Outcomes of interest include diagnostic test accuracy, survival (overall and disease-free), response rates, quality of life, and adverse effects of treatment.

Bowel Preparation for Colonoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Guideline

Year: 2013
AGREE II score: Available
Developer organization: European Society of Gastrointestinal Endoscopy (ESGE)
A clinical practice for patients with cervical intraepithelial neoplasia. The guideline examines the use of cryotherapy based on lesion size and other risk factors. Recommendations on technique are included, and comparisons are made to loop electrosurgical excision procedures.

Guidelines for the Investigation and Management of Mantle Cell Lymphoma

Year: 2012
AGREE II score: Available
Developer organization: British Committee for Standards in Haematology
This is a clinical practice guideline for patients with mantle cell lymphoma. The guideline provides recommendations on diagnostic procedures, initial investigations, and treatment including first- and second-line management. Outcomes of interest include survival (progression and overall) and overall response rate to treatment.

Provincial Hodgkin’s Lymphoma Treatment Guidelines

Year: 2012
AGREE II score: Unavailable
Developer organization: Saskatchewan Cancer Agency
This is a clinical practice guideline for Hodgkin's lymphoma patients in Saskatchewan. The guideline provides an overview of procedures related to diagnosis, staging, treatment, relapse treatment, and follow-up for Hodgkin's lymphoma. The guideline considers both remission and palliative treatment outcomes.

National Breast Cancer Screening Clinical Practice Guideline

Year: 2012
AGREE II score: Available
Developer organization: Kaiser Permanente
A clinical practice guideline for the screening of women for breast cancer who are asymptomatic. This guideline examines diagnostic and screening procedures when risk factors are and are not present. Potential risk factors are enumerated and recommendations are made based on age and covariants. Outcomes include risk estimates, over- and under-diagnosis harms, and screening effectiveness.

Lymphoma

Year: 2012
AGREE II score: Available
Developer organization: Alberta Health Services
This is a clinical practice guideline on the diagnosis, staging, treatment, supportive interventions and follow-up care for adult patients with lymphoma. Staging techniques include immunohistochemical and fluorescence in situ hybridization (FISH) testing. Treatment and management options are discussed for Hodgkin and non-Hodgkin lymphomas, with recommendations based on cancer type and stage. Outcomes of interest include response rates, disease progression, survival, remission, and adverse effects.

Management of Chronic Myeloid Leukemia

Year: 2012
AGREE II score: Available
Developer organization: Alberta Health Services
This is a clinical practice guideline on the management of chronic myeloid leukemia in patients over 18 years of age. The guideline provides recommendations on staging and prognosis, diagnosis and baseline investigations, treatment options, and treatment response assessment. First and second generation TKI's, induction chemotherapy, allogeneic stem cell transplant, and interferon-a are all discussed as treatment options. Outcomes of interest include treatment efficacy, survival rate, disease progression, and adverse events.

ICUD-EAU International Consultation on Bladder Cancer 2012: Urothelial Carcinoma of the Prostate

Year: 2012
AGREE II score: Unavailable
Developer organization: European Association of Urology
This is a clinical practice guideline for urothelial carcinoma (UC) of the prostate. This guideline provides diagnosis, treatment, and follow-up recommendations. Areas of interest include treatment with intravesical bacillus Calmetter-Guerin (BCG), transurethral biopsy of the prostatic urethra, as well as radical cystoprostatectomy.

Bone Sarcomas: ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-Up

Year: 2012
AGREE II score: Unavailable
Developer organization: European Society for Medical Oncology
This is a clinical practice guideline for the management of bone sarcomas including osteosarcoma, Ewing sarcoma, high-grade spindle/pleomorphic sarcomas of bone, chondrosarcoma, giant cell tumour of bone, and chordoma. The guideline provides recommendations on diagnostic assessment and staging, treatment, and follow-up care. Outcomes of interest include incidence of subtypes, local recurrence, and survival.

Thymic Neoplasms

Year: 2012
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for patients with thymic neoplasms. The guideline examines staging based treatment and follow up, focusing on surgical resection and postoperative radiotherapy. Outcomes of interest include reduced relapse and improved multimodal treatment regimens.

Initial Staging for Squamous Cell Carcinoma of the Mouth, Larynx and Pharynx (Except Nasopharynx) Part 3: General Assessment

Year: 2012
AGREE II score: Unavailable
Developer organization: French Otorhinolaryngology - Head and Neck Surgery Society (SFORL)
This clinical practice guideline is part 3 of a 3 part series on the initial staging of squamous cell carcinoma of the oral cavity, larynx and pharynx (excluding nasopharynx). This guideline discusses screening, assessment and initial management of risk factors (smoking, alcohol, HPV), frequent medical comorbidities, nutritional status, social and psychological status, dental status, pain and possible anemia. The guideline also outlines chemotherapy work-up and work-up for microanastomosed free-flap cervicofacial reconstruction.

American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology Screening Guidelines for the Prevention and Early Detection of Cervical Cancer

Year: 2012
AGREE II score: Available
Developer organization: American Cancer Society
This is a clinical practice guideline on the prevention and detection of cervical cancer in non high-risk adult women. The guideline examines harms and benefits of screening, use of HPV testing and cytology as screening techniques, screening strategies for different age and risk groups, and management of abnormal screening results including colposcopy. Screening recommendations for women vaccinated against HPV16 and HPV18 are also discussed. Outcomes of interest include incidence and survival rate, sensitivity, specificity, and rate of false positives and negatives.

Referral of Patients with Suspected Colorectal Cancer by Family Physicians and Other Primary Care Providers

Year: 2012
AGREE II score: Available
Developer organization: Cancer Care Ontario
This clinical guideline examines the management of adult patients presenting in primary care settings with signs and/or symptoms of colorectal cancer. Clinical presentation (focused history and physical examination), referral, and recommendations to reduce diagnostic delay are discussed. Assessment techniques include digital rectal examination, physical examination, complete blood count (CBC), fecal occult blood test (FOBT), computed tomographic (CT) colonography and double-contrast barium enema (DCBE). Outcomes of interest are positive predictive values for colorectal cancer.

American Thyroid Association Guidelines for Management of Patients with Anaplastic Thyroid Cancer

Year: 2012
AGREE II score: Unavailable
Developer organization: American Thyroid Association
A clinical practice guideline for the management for anaplastic thyroid cancer patients. The guideline examines diagnosis and initial evaluation, primarily through biopsy, and provides treatment options including surgery and systemic therapies. The guideline also considers nutritional support needs and appropriate standards of palliative care. Outcomes of interest include the use of intensity-modulated radiation therapy in improving survival, and overall improved 1-year survival rates.

Learning, Techniques, and Complications of Endoscopic Ultrasound (EUS)-Guided Sampling in Gastroenterology: European Society of Gastro- intestinal Endoscopy (ESGE) Technical Guideline

Year: 2012
AGREE II score: Available
Developer organization: European Society of Gastrointestinal Endoscopy (ESGE)
This clinical practice guideline examines endoscopic ultrasound (EUS)-guided sampling in gastroenterology. Topics of discussion include learning of procedure, surgical techniques, complications and their prevention, and the processing of specimens obtained with EUS-guided fine needle aspiration or EUS-guided Trucut biopsy. Outcomes of interest include diagnostic accuracy, malignancy, morbidity, complication rate and procedure-related mortality.

European Guidelines for Quality Assurance in Colorectal Cancer Screening and Diagnosis: First Edition

Year: 2012
AGREE II score: Available
Developer organization: International Agency for Research on Cancer
A clinical practice guideline for the screening and surveillance of patients at risk for colorectal cancer. The guideline examines quality assurance and professional requirements for common screening procedures, such as endoscopy and fecal occult blood tests, and including recommendations for follow-up and treatment timing. Outcomes of interest include improved safety and improved patient experience.

Melanoma Guideline 2012

Year: 2012
AGREE II score: Unavailable
Developer organization: Integraal Kankercentrum Nederland
A clinical practice guideline for patients with melanoma of the skin. The guideline examines management and daily practice support for melanoma, including genetic risk-based screening, and appropriate excision. Outcomes of interest include reduced recurrence through larger excision margins and improved prevention recommendations.

European Guidelines for Diagnosis and Treatment of Adenovirus Infection in Leukemia and Stem Cell Transplantation: Summary of ECIL-4 (2011)

Year: 2012
AGREE II score: Unavailable
Developer organization: European Conference on Infections in Leukemia (ECIL)
A clinical practice guideline for adult and pediatric patients with leukemia or undergoing stem cell transplantation who have contracted, or are at risk of contracting, adenovirus infections. The guideline examines diagnostic techniques, and appropriate antiviral therapy depending on prior treatment. Outcomes of interest include improved treatment of probable disease and improved preemptive treatment.

Provincial Melanoma Treatment Guidelines

Year: 2012
AGREE II score: Unavailable
Developer organization: Saskatchewan Cancer Agency
A clinical practice guideline for patients with suspected or confirmed melanoma. The guideline examines management, including pathology, and imaging and treatment recommendations based on staging. Outcomes of interest include special considerations for Braff mutations and reduced unnecessary follow up testing.

Practice Parameters for Anal Squamous Neoplasms

Year: 2012
AGREE II score: Unavailable
Developer organization: American Society of Colon and Rectal Surgeons
A clinical practice guideline for patients with squamous-cell carcinoma of the anus. The guideline examines pre-treatment evaluation, treatment, and post-treatment surveillance, with specific recommendations for HIV-positive patients. Outcomes of interest include increased support for intensity-modulated radiation therapy-based chemoradiotherapy as a primary treatment, and specifically for HIV-positive patients with higher toxicity risks.

Bone Sarcomas: ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-up

Year: 2012
AGREE II score: Unavailable
Developer organization: European Society for Medical Oncology
This clinical practice guideline is for cancer patients who are being considered for anti-TNF-alpha therapy. Treatment related infections are reviewed, including tuberculosis, human papilloma virus, hepatitis B and C, Varicella zoster virus, Herpes simplex virus, cytomegalovirus, Epstein Barr virus and human immunodeficiency virus. The guideline discusses risk factors for developing infection, and provides recommendations on preventative measures such as vaccination for at-risk individuals.

Guidelines on the Diagnosis, Investigation and Management of Chronic Lymphocytic Leukaemia

Year: 2012
AGREE II score: Unavailable
Developer organization: British Committee for Standards in Haematology
This clinical practice guideline reviews the diagnosis, clinical and laboratory evaluation, and treatment of chronic lymphocytic leukaemia (CLL). Autoimmune complications in CLL and supportive care are also discussed. Outcomes of interest include partial response and complete response to treatment, and overall and progression-free survival.

PET Evidence from Primary Studies and Systematic Reviews and Recommendations from Clinical Practice Guidelines January to June 2011

Year: 2012
AGREE II score: Unavailable
Developer organization: Cancer Care Ontario
A clinical practice guideline summarizing the use of positron emission tomography (PET) in the diagnosis, staging, and treatment of patients with cancer. The guideline provides literature updates on PET use for multiple types of cancer. Outcomes of interest include recurrence times and safety outcomes.

Anaplastic Astrocytomas and Oligodendrogliomas

Year: 2012
AGREE II score: Available
Developer organization: Alberta Health Services
This is a clinical practice guideline for the management and treatment of suspected or confirmed WHO grade III anaplastic astrocytomas or oligodendrogliomas in patients over 18 years of age. Comparisons are made between surgical resection and biopsy, and radiation therapy and chemotherapy are discussed as treatment options. Outcomes of interest include diagnostic accuracy, prognostic prediction, and overall survival.

18-Fluorodeoxyglucose Positron Emission Tomography in the Diagnosis and Staging of Lung Cancer

Year: 2012
AGREE II score: Available
Developer organization: Cancer Care Ontario
A clinical practice guideline for the use of positron emission tomography PET scans in patients in adult patients with lung cancer. The guideline examines the use of PET scans in the diagnosis and staging of solitary pulmonary nodules, small-cell lung cancer and non-small-cell lung cancer. Outcomes of interest include imaging accuracy and the impact of new PET scan technologies.

Soft Tissue and Visceral Sarcomas: ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-Up

Year: 2012
AGREE II score: Unavailable
Developer organization: European Society for Medical Oncology
A clinical practice guideline for the management of patients with soft tissue and visceral sarcomas. The guideline examines surgical intervention with systemic therapies, following diagnosis and staging through imaging and core needle biopsies. Considerations include risk of relapse and differences in treatment for special presentations.

Renal Cell Carcinoma

Year: 2012
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for the management of patients with renal cell carcinoma. The guideline examines diagnostic assessment and appropriate first and second line therapies, including surgical and minimally invasive therapies. Outcomes of interest include increased assessment for treatment tolerance, and improved median survival.

Consensus Statements for Management of Barrett’s Dysplasia and Early-Stage Esophageal Adenocarcinoma, Based on a Delphi Process

Year: 2012
AGREE II score: Available
Developer organization: Barrett's Dysplasia and Cancer Taskforce (BAD CAT)
This clinical practice guideline provides recommendations on the management of patients with Barrett's esophagus (BE) and low-grade dysplasia (LGD), high-grade dysplasia (HGD), or early- stage esophageal adenocarcinoma (EA). Diagnosis of BE and HGD, risk factors for EA and surveillance of at-risk patients, and treatment of HGD and early EA are discussed.

Prostate Cancer Screening– Position Statement

Year: 2012
AGREE II score: Unavailable
Developer organization: Cancer Care Nova Scotia
A clinical practice guideline for asymptomatic adult males at risk for prostate cancer. The guideline examines recommendations for screening on an individual basis to increase the diagnosis of early stage prostate cancer. Considerations regarding frequency of screening include life expectancy and risk factors such as family history.

Colposcopic Management of Abnormal Cervical Cytology and Histology

Year: 2012
AGREE II score: Available
Developer organization: Society of Obstetricians and Gynaecologists of Canada
This is a clinical practice guideline on the management of abnormal cytology results after screening for cervical cancer. Treatment follow-up algorithms are provided, and management options include biopsy, diagnostic excisional procedure including loop electrosurgical excision procedure (LEEP) , and hysterectomy. Outcomes of interest include risk factors for developing cancer, and benefits and harms of follow-up options.

The Organization and Delivery of Healthcare Services for Head and Neck Cancer Patients

Year: 2012
AGREE II score: Available
Developer organization: Alberta Health Services
This is a professional guideline that provides recommendations on the organization and delivery of health-care services for head and neck cancer patients in Alberta. The guideline outlines the professional health-care team involved in the treatment of head and neck cancer patients, including their roles and minimum required qualifications. It also provides guidance on minimum infrastructure requirements, optimal cancer centre and team member volumes, and wait times to care from referral to initiation of curative treatment.

Gestational Trophoblastic Neoplasia

Year: 2012
AGREE II score: Available
Developer organization: Alberta Health Services
This is a clinical practice guideline for women with gestational trophoblastic neoplasia, including invasive mole, choriocarcinoma, and placental site trophoblastic tumour. The guideline provides recommendations on diagnostic assessment, staging, prognostic scoring, treatment, and follow-up procedures. Outcomes of interest include diagnostic accuracy, complete response rate, survival rate, and risk of subsequent abnormal pregnancy.

ECIL Recommendations for the Use of Biological Markers for the Diagnosis of Invasive Fungal Diseases in Leukemic Patients and Hematopoietic SCT Recipients

Year: 2012
AGREE II score: Unavailable
Developer organization: European Conference on Infections in Leukemia (ECIL)
This is a clinical practice guideline for adult patients who have leukemia and/or are hematopoietic stem cell transplant recipients. The guideline provides recommendations on the use of biological tests to screen for invasive fungal diseases including invasive aspergillosis (IA), invasive candidiasis (IC), and cryptococcosis. Galactomannan (GM), b-glucan (BG), Cryptococcus Ag, mannan (Mn) Ag/anti-mannan (A-Mn) Ab, and PCR are examined as potential screening tests. Outcomes of interest include sensitivity, specificity, and positive and negative predictive values.

Practice Parameters for the Management of Colon Cancer

Year: 2012
AGREE II score: Unavailable
Developer organization: American Society of Colon and Rectal Surgeons
A clinical practice guideline for patients with colon cancer. The guideline examines risk assessment and treatment, primarily through surgical resection. Outcomes of interest include improved prediction of outcomes through histologic grading and reduced surgical morbidity in palliative procedures.

Clinical Practice Guidelines for Multiple Endocrine Neoplasia Type 1 (MEN1)

Year: 2012
AGREE II score: Unavailable
Developer organization: Endocrine Society
This is a clinical practice guideline for the management of patients with multiple endocrine neoplasia (MEN) type 1 (MEN1) and their families. Recommendations are provided for genetic testing and screening, diagnosis, and treatment of MEN1 related tumours. Organization of care is also discussed.

Gastrointestinal Stromal Tumors: ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-Up

Year: 2012
AGREE II score: Unavailable
Developer organization: European Society for Medical Oncology
This is a clinical practice guideline for head and neck cancer patients (HNCPs) undergoing radiotherapy. The guideline reviews dysphagia mechanisms and causes in HNCPs and provides recommendations on the management of patients undergoing radiotherapy who have pre-treatment dysphagia or are at risk for dysphagia. The occurrence of dysphagia in post-surgical radiotherapy or after chemoradiotherapy is also discussed.

Guidelines for the Diagnosis and Treatment of Cholangiocarcinoma: An Update

Year: 2012
AGREE II score: Unavailable
Developer organization: British Society of Gastroenterology
This is a clinical practice guideline for the management of patients with cholagiocarcinoma or suspected cholagiocarcinoma. The guideline discusses risk factors, diagnosis and staging, and treatment options. Outcomes of interest include survival, time-to-progression, tumour control rate, and rate of surgical complications.

Recommendations from the EGAPP Working Group: Can Testing of Tumor Tissue for Mutations in EGFR Pathway Downstream Effector Genes in Patients with Metastatic Colorectal Cancer Improve Health Outcomes by Guiding Decisions Regarding Anti-EGFR Therapy?

Year: 2012
AGREE II score: Unavailable
Developer organization: Evaluation of Genomic Applications in Practice and Prevention Working Group
This recommendation statement explores the use of pharmacogenomic testing of tumour in patients with metastatic colorectal cancer to predict response to anti-EGFR antibody therapy (cetuximab or panitumumab). The guideline reviews analytic and clinical validity of testing for selected pharmacogenomic tests including codon 12 and 13 mutations in KRAS, the BRAF V600E mutation, variants in NRAS and in PIK3CA, and loss of PTEN and AKT protein expression. Outcomes of interest include overall or progression-free survival and treatment-related adverse events.

Referral of Suspected Prostate Cancer by Family Physicians and Other Primary Care Providers

Year: 2012
AGREE II score: Available
Developer organization: Cancer Care Ontario
This clinical guideline examines the management of adult male patients presenting in primary care settings with signs or symptoms of prostate cancer. Management of patients presenting with unexplained symptoms of metastatic cancer, lower urinary tract symptoms (LUTS), or incidental PSA (defined as results not ordered by the attending family physician/primary care provider), are discussed. Assessment techniques include digital rectal examination (DRE), PSA tests, and prostate cancer nomograms.

Management of Precancerous Conditions and Lesions in the Stomach (MAPS): Guideline from the European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter Study Group (EHSG), European Society of Pathology (ESP), and the Sociedade Portuguesa de Endoscopia Digestiva (SPED)

Year: 2011
AGREE II score: Available
Developer organization: European Society of Gastrointestinal Endoscopy (ESGE)
A clinical practice guideline for the management of patients with premalignant atrophic gastritis, intestinal metaplasia, and epithelial dysplasia at risk for gastric cancers. The guideline makes recommendations for staging, treatment, and follow-up for precancerous gastric conditions to improve the diagnosis of early stage cancer. Outcomes of interest include Helicobacter pylori eradication, pharmacological options, and an analysis of patient benefits in terms of cost-effectiveness.

Guidelines on the Investigation and Management of Follicular Lymphoma

Year: 2011
AGREE II score: Unavailable
Developer organization: British Committee for Standards in Haematology
This is a clinical practice guideline on the diagnosis and laboratory investigation, treatment management, follow-up and monitoring of patients with follicular lymphoma (FL). Topics of interest include the use of prognostic scoring systems and the role of autologous and allogeneic transplant in the treatment of FL. Outcomes of interest include survival (overall, event-free and progression free), relapse risk, transplant-related mortality and overall response rate to treatment.

Management of Suspected Ovarian Masses in Premenopausal Women

Year: 2011
AGREE II score: Available
Developer organization: Royal College of Obstetricians & Gynaecoloists (RCOG)
This is a clinical practice guideline for non-pregnant, premenopausal women with suspected ovarian masses. The guideline examines the management of ovarian masses including blood tests, pelvic ultrasound, and MRI as diagnostic assessment tools, and additionally reviews tools for estimating risk of malignancy. Other topics include follow-up care and treatment of benign cysts. Outcomes of interest include sensitivity and specificity of diagnostic tests, effectiveness of surgery, and recurrence rates.

Non-Small Cell Lung Cancer Stage II

Year: 2011
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for patients with stage II non-small cell lung cancer. The guideline examines diagnostic workup, treatment, and follow up for operable and inoperable patients. Outcomes of interest include improved early detection of recurrence and reduced complications through video-assisted thoracic surgery.

Guidelines for the Management of Gastroenteropancreatic Neuroendocrine (Including Carcinoid) Tumours (NETs)

Year: 2011
AGREE II score: Unavailable
Developer organization: UK and Ireland Neuroendocrine Tumour Society
This is a clinical practice guideline for patients with gastroenteropancreatic neuroendocrine (including carcinoid) tumours (NETs). Genetic risk factors, diagnostic assessment including imaging and pathology, and treatment are discussed. Special topics of interest include genetic risk factors and association of NETs with carcinoid heart disease (CHD). Outcomes of interest include survival rates, sensitivity of diagnostic testing procedures, adverse effects and quality of life.

Non-Small Cell Lung Cancer Stage I

Year: 2011
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for patients with non-small cell lung cancer. The guideline examines diagnosis, treatment, and follow up, with a focus on surgical resection as the preferred therapy. Outcomes of interest include fewer complications through video-assisted thoracic surgery and improved control with stereotactic body radiation therapy.

PET Six-Month Monitoring Report 2010-2: Evidence from Primary Studies and Systematic Reviews and Recommendations from Clinical Practice Guidelines July to December 2010

Year: 2011
AGREE II score: Unavailable
Developer organization: Cancer Care Ontario
A clinical practice guideline for the use of positron emission tomography (PET) in the diagnosis, staging, and treatment of patients with cancer. This guideline provides an updated literature review for multiple adult cancers. Outcomes of interest include recurrence and safety outcomes.

CAR CT Colonography Standards

Year: 2010
AGREE II score: Unavailable
Developer organization: Canadian Association of Radiologists
This is a clinical and professional practice guideline that recommends standards of best practice for the use of CT colonography in the screening and diagnostic assessment of colorectal cancer. The guideline discusses patient information and consent, CT technique, patient experience and safety, and interpretation of results. Additional topics include radiologist training/assessment, use of endoscopy as a post-CT test, and resource allocation.

Guidelines of the European Respiratory Society and the European Society of Thoracic Surgeons for the Management of Malignant Pleural Mesothelioma

Year: 2009
AGREE II score: Available
Developer organization: European Respiratory Society
A clinical practice guideline for the diagnosis, staging, and treatment of predominantly male patients with malignant pleural mesothelioma. The guideline examines the epidemiology of malignant mesothelioma and considers staging and treatment options including surgery, radiotherapy, and chemotherapy. Guidance is also provided for tumour response evaluation and management of symptoms.