Cancer Guidelines Database

Access quality cancer guidelines from a single Canadian source

We've listed 45 guidelines under your selection of "Type of cancer". The most recent guidelines are first.

Neuroendocrine and Adrenal Tumors, Version 2.2020

Year: 2020
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with neuroendocrine or adrenal tumours. The guideline discusses the diagnosis, staging, treatment, and follow-up of patients with sporadic neuroendocrine tumours, originating from organs such as the lungs, thymus, and gastrointestinal (GI) tract. The guideline also examines the role of the genetic syndrome, multiple endocrine neoplasia (MEN), in developing parathyroid, pituitary, and pancreatic tumours.

Neuroendocrine Tumours

Year: 2019
AGREE II score: Unavailable
Developer organization: BC Cancer Agency
This is a clinical practice guideline for adult patients with neuroendocrine tumours. The guideline examines diagnosis using histological markers and imaging, management of tumours through appropriate treatment strategies, and appropriate time periods for follow-up. Recommendations are presented for both non-pancreatic and pancreatic neuroendocrine tumours. Please note that the sub-sections within this set were published and revised at varying dates, and that the publication year referenced here refers only to the date that the guideline set was accessed online.

Anticonvulsant Prophylaxis and Steroid Use in Adults With Metastatic Brain Tumors: ASCO and SNO Endorsement of the Congress of Neurological Surgeons Guidelines

Year: 2019
AGREE II score: Available
Developer organization: American Society of Clinical Oncology
This clinical practice guideline is an endorsement of two 2019 guidelines published by the Congress of Neurological Surgeons on the use of anticonvulsant prophylaxis and steroids in adults with metastatic brain tumours. Specific topics addressed include the choice of steroid, steroid dose and duration of administration, and primary outcomes of interest were decreases in frequency of seizures, as well as increases in quality of life and survival.

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on the Role of Emerging and Investigational Therapies for the Treatment of Adults With Metastatic Brain Tumors

Year: 2019
AGREE II score: Available
Developer organization: The Congress of Neurological Surgeons and the Section on Tumors
This clinical practice guideline is part of a series of guidelines for the management of adult patients with newly diagnosed metastatic brain tumours, excluding radiosensitive tumour histologies. The guideline focuses on non-standard or 'emerging' techniques for the treatment of these patients. Outcomes of interest include local response, progression-free survival, and local recurrence.

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on the Role Of Steroids in the Treatment of Adults With Metastatic Brain Tumors

Year: 2019
AGREE II score: Available
Developer organization: The Congress of Neurological Surgeons and the Section on Tumors
This clinical practice guideline is part of a series of guidelines for the management of adult patients with newly diagnosed metastatic brain tumours, excluding radiosensitive tumour histologies. The guideline examines the impact of steroids on neurological symptoms and/or quality of life in these patients, compared to supportive care alone or other treatment options. The choice of steroid, steroid dose and duration of administration are also discussed. Recommendations provided are stratified by severity of symptoms related to mass effect.

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on Treatment Options for Adults With Multiple Metastatic Brain Tumors

Year: 2019
AGREE II score: Available
Developer organization: The Congress of Neurological Surgeons and the Section on Tumors
This clinical practice guideline is part of a series of guidelines for the management of adult patients with newly diagnosed metastatic brain tumours, excluding radiosensitive tumour histologies. The guideline examines treatment options specifically for patients with multiple metastatic brain tumours. Treatment options discussed include whole brain radiation therapy (WBRT) and stereotactic radiosurgery (SRS).

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Role of Chemotherapy in the Management of Adults With Newly Diagnosed Metastatic Brain Tumors

Year: 2019
AGREE II score: Available
Developer organization: The Congress of Neurological Surgeons and the Section on Tumors
This clinical practice guideline is part of a series of guidelines for the management of adult patients with newly diagnosed metastatic brain tumours, excluding radiosensitive tumour histologies. The guideline discusses the use of chemotherapy for the treatment of these patients, and examines the use of chemotherapy alone, chemotherapy in addition to whole brain radiation therapy (WBRT), and chemotherapy in addition to stereotactic radiosurgery (SRS). The sequence of treatments and number of chemotherapeutic regimens are also considered.

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Use of Stereotactic Radiosurgery in the Treatment of Adults With Metastatic Brain Tumors

Year: 2019
AGREE II score: Available
Developer organization: The Congress of Neurological Surgeons and the Section on Tumors
This clinical practice guideline is part of a series of guidelines for the management of adult patients with newly diagnosed metastatic brain tumours, excluding radiosensitive tumour histologies. The guideline examines the use of stereotactic radiosurgery for the treatment of these patients. Stereotactic radiosurgery (SRS) is compared with other treatment modalities, and the guideline also discussed the role of SRS after open surgical resection of brain metastasis, and the role of SRS alone for the management of patients with one to four brain metastases.

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Role of Surgery in the Management of Adults With Metastatic Brain Tumors

Year: 2019
AGREE II score: Available
Developer organization: The Congress of Neurological Surgeons and the Section on Tumors
This clinical practice guideline is part of a series of guidelines for the management of adult patients with newly diagnosed metastatic brain tumours, excluding radiosensitive tumour histologies. The guideline provides recommendations on the surgical management of these patients. Surgery alone, surgery with stereotactic radiosurgery (SRS), and surgery with whole brain radiation therapy (WBRT) are all discussed.

Neuroendocrine and Adrenal Tumours, Version 4.2018

Year: 2019
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with neuroendocrine or adrenal tumours. The guideline discusses the diagnosis, staging, treatment, and follow-up of patients with sporadic neuroendocrine tumours, originating from organs such as the lungs, thymus, and gastrointestinal (GI) tract. The guideline also examines the role of the genetic syndrome, multiple endocrine neoplasia (MEN), in developing parathyroid, pituitary, and pancreatic tumours.

Management of Epilepsy in Brain Tumors

Year: 2019
AGREE II score: Available
Developer organization: Italian League Against Epilepsy
This is a clinical practice guideline for patients with brain tumours. The guideline provides recommendations for the management of brain tumour-related epilepsy (BTE) in these patients. Specifically, the guideline provides recommendations for the diagnosis and treatment of BTE, including which anti-epileptic medications should be used.

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Role Of Prophylactic Anticonvulsants in the Treatment of Adults With Metastatic Brain Tumors

Year: 2019
AGREE II score: Available
Developer organization: The Congress of Neurological Surgeons and the Section on Tumors
This clinical practice guideline is part of a series of guidelines for the management of adult patients with newly diagnosed metastatic brain tumours, excluding radiosensitive tumour histologies. The guideline examines the role of prophylactic anticonvulsants during the treatment of these patients. Reducing the number of seizures experienced by these patients is the primary outcome of interest.

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Role of Whole Brain Radiation Therapy in Adults With Newly Diagnosed Metastatic Brain Tumors

Year: 2019
AGREE II score: Available
Developer organization: The Congress of Neurological Surgeons and the Section on Tumors
This clinical practice guideline is part of a series of guidelines for the management of adult patients with newly diagnosed metastatic brain tumours, excluding radiosensitive tumour histologies. The guideline examines the role of whole brain radiation therapy (WBRT) for the treatment of these patients. Topics of interest include optimal dose/fractionation schedule, the impact tumour histopathology or molecular status has on the decision to use WBRT, and the dose fractionation scheme utilized.

Organizational Guideline for the Delivery of Stereotactic Radiosurgery for Brain Metastasis in Ontario

Year: 2019
AGREE II score: Unavailable
Developer organization: Cancer Care Ontario
This is an organizational guideline for adult patients with brain metastases who are eligible to receive stereotactic radiosurgery (SRS) in Ontario. Topics of discussion include qualifications for the practice team, the determination of patient eligibility, appropriate technologies for the delivery of SRS, as well as pre- and post-intervention imaging.

Brain Tumours (Primary) and Brain Metastases in Adults

Year: 2018
AGREE II score: Available
Developer organization: National Institute for Health and Care Excellence
This is a clinical practice guideline for patients aged 16 or older who have primary brain tumours or brain metastases. Specifically, the guideline examines the diagnoses and management of radiologically identified glioma, meningioma, and brain metastases. Follow-up care after treatment and supportive care are also discussed, and additional recommendations are provided on the referral of adults with primary brain tumours or brain metastases for neurological rehabilitation assessment.

Gallium-68 PET Imaging in Neuroendocrine Tumours

Year: 2018
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adult and pediatric patients with suspected or diagnosed well-differentiated neuroendocrine tumours (NETs). The guideline discusses the clinical utility of Gallium-68 positron emission tomography (PET) compared with PET / computed tomography imaging for the initial diagnosis, staging, re-staging, response evaluation, and routine surveillance of patients with NETs.

Recommendations for Filgrastim Use in Adults by Disease Site

Year: 2018
AGREE II score: Unavailable
Developer organization: Cancer Care Manitoba
This is a clinical practice guideline for adult oncology patients with neutropenia. The guideline examines the appropriate prescribing of filgrastim for these patients. Indications for which filgrastim should be used are discussed by disease site group. Disease site groups considered include breast, central nervous system, gastrointestinal, gynecologic, genitourinary, hematologic, and thoracic, amongst others.

European Society of Endocrinology Clinical Practice Guidelines for the Management of Aggressive Pituitary Tumours and Carcinomas

Year: 2018
AGREE II score: Available
Developer organization: European Society of Endocrinology
This is a clinical practice guideline for patients with aggressive pituitary tumours and carcinomas, which provides recommendations on diagnosis, treatment, and follow-up. Treatment options such as surgery, radiotherapy, and temozolomide are examined. Further guidance on dosing regimens, adverse effects, discontinuation, and combination chemotherapies is provided for temozolomide. Recurrence, non-responders, and systemic metastasis are also discussed.

Neuroendocrine and Adrenal Tumors, Version 2.2018

Year: 2018
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for patients with neuroendocrine or adrenal tumours. The guideline discusses the diagnosis, staging, treatment, and follow-up of patients with sporadic neuroendocrine tumours, originating from organs such as the lungs, thymus, and gastrointestinal (GI) tract. The guideline also examines the role of the genetic syndrome, multiple endocrine neoplasia (MEN), in developing parathyroid, pituitary, and pancreatic tumours.

Stereotactic Radiosurgery: Benign Indications

Year: 2017
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adults with benign brain tumors. The guideline examines the appropriateness of stereotactic radiosurgery for treating these patients, as well as the appropriate dose for stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (FSRT). Recommendations are provided for benign brain tumors that can be treated with stereotactic radiotherapy, including vestibular schwannoma, pituitary adenomas, meningiomas, and other indications such as craniopharyngiomas and hemangioblastomas.

Management of Primary Central Nervous System Diffuse Large B-Cell Lymphoma (PCNS DLBCL)

Year: 2017
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical guideline for the treatment of primary central nervous system diffuse large B-cell lymphoma (PCNS DLBCL). The guideline provides recommendations regarding chemotherapy and radiation therapy and the optimal regimens, radiation dose and schedule. Outcomes of interest include overall survival, measure of disease control (response rates and progression-free survival), and frequency of adverse events.

SEOM Clinical Guidelines for Anaplastic Gliomas (2017)

Year: 2017
AGREE II score: Unavailable
Developer organization: Spanish Society of Medical Oncology
This is a clinical practice guideline for the diagnosis, treatment and follow-up of adult patients with anaplastic gliomas. The guideline provides a diagnostic algorithm for anaplastic gliomas that considers isocitrate dehydrogenase 1/2 (IDH1/IDH2) missense mutations and 1p/19q co-deletions. Topics of discussion include radiology, histology and molecular biology, prognostic factors, surgery, radiotherapy, options for first-line systemic treatment, support treatment (e.g., corticoids and anticonvulsants), and follow-up.

EANO Guidelines for the Diagnosis and Treatment of Ependymal Tumours

Year: 2017
AGREE II score: Unavailable
Developer organization: European Association of Neuro-Oncology (EANO)
This is a clinical practice guideline for children and adults with ependymal tumours. The guideline provides recommendations for the diagnosis, staging, treatment and follow-up of these patients. Radiological, histological, and molecular components of diagnostic assessment are discussed, and treatment approaches involving surgery and radiation therapy are examined.

EANO–ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-up of Patients with Leptomeningeal Metastasis from Solid Tumours

Year: 2017
AGREE II score: Available
Developer organization: European Society for Medical Oncology
This is a clinical practice guideline for patients with leptomeningeal metastases from solid tumours. The guideline discusses the diagnosis, treatment, and follow-up of these patients, and a treatment algorithm is presented based on life expectancy. Treatment options examined include systemic pharmacotherapy, intra-cerebrospinal fluid pharmacotherapy, focal radiotherapy (RT), and whole brain radiotherapy (WBRT).

Guidelines for the Treatment of Central Nervous System Metastases Using Radiosurgery

Year: 2017
AGREE II score: Unavailable
Developer organization: Brazilian Society of Radiotherapy
This a clinical practice guideline on the use of radiosurgery for the treatment of patients with central nervous system (CNS) metastatic tumours. Treatment efficacy, safety, toxicity are specifically discussed. The guideline also considers the benefits and disadvantages of performing two treatment modalities involving radiosurgery, as well as the role adjuvant radiosurgery.

Brain Oligometastases

Year: 2017
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients with four or fewer brain metastases. The guideline examines the important prognostic factors for assessing and managing these patients, the role of surgery and radiotherapy in the management of oligometastatic disease, and the appropriate follow-up and surveillance strategy. Treatments considered include whole brain radiation therapy (WBRT) and stereotactic radiosurgery (SRS), both alone and in conjunction.

SEOM Clinical Guideline of Diagnosis and Management of Low Grade Glioma (2017)

Year: 2017
AGREE II score: Unavailable
Developer organization: Spanish Society of Medical Oncology
This is a clinical practice guideline for adults with low-grade gliomas (LGG), including oligodendrogliomas and astrocytomas. The guideline provides recommendations for the diagnosis, management and follow-up of these patients. Radiological evaluation, surgical options, and the use and timing of complementary treatment (i.e. adjuvant chemotherapy and radiation therapy) after surgery are specifically discussed.

European Society of Endocrinology Clinical Practice Guideline for Long-Term Follow-Up of Patients Operated on for a Phaeochromocytoma or a Paraganglioma

Year: 2016
AGREE II score: Available
Developer organization: European Society of Endocrinology
This is a clinical practice guideline for patients who have been operated on for a pheochromocytoma or a paraganglioma. The guideline discusses the long-term follow-up of these patients, and includes recommendations on diagnosing malignancy, perioperative work-up, duration of follow-up, monitoring methods, as well as specific considerations for pregnant women and patients who are frail and/or elderly.

Recommendations for Filgrastim Use in Adults by Disease Site

Year: 2016
AGREE II score: Unavailable
Developer organization: Cancer Care Manitoba
This is a clinical practice guideline to guide appropriate prescribing of filgrastim in adults. The guidelines looks at a variety of disease sites and is intended as a guide to facilitate a shared approach to the appropriate use of filgrastim. In order provide clarity surrounding the indications in which filgrastim should be used, the recommendations are presented by disease site.

Tobacco Screening and Treatment for Adult Cancer Patients

Year: 2016
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adults (aged 18 and older) at any phase of the cancer care continuum regardless of cancer type, stage (including metastatic) or treatment plan, with some components of the guideline also applicable to the patient's family and/or caregivers. Recommendations are provided on implementation of the brief tobacco intervention using the evidence-based AAR Brief Tobacco Intervention Model which includes screening, education and assessment, treatment plan, and referral, monitoring, and follow-up. The 2015 guideline was revised in June 2016 to abbreviate the cessation intervention model to best support adoption across all CCA clinics and settings. Clinical considerations and contraindications of treatment options for cancer patients are discussed including nicotine replace therapy (NRT), bupropion, varenicline, and e-cigarettes, and the impact of tobacco use on cancer treatment is reviewed with a specific focus on erlotinib and irinotecan.

CGCG Clinical Practice Guidelines for the Management of Adult Diffuse Gliomas

Year: 2016
AGREE II score: Unavailable
Developer organization: Chinese Glioma Cooperative Group
This is a clinical practice guideline for adults with diffuse gliomas. Diagnosis, as well as treatment methods including chemotherapy, radiation therapy, and surgical procedures are discussed. The guideline provides general recommendations, as well as specific recommendations for low grade gliomas (WHO grade II), anaplastic gliomas (WHO grade III), and glioblastoma (WHO grade IV).

Low-Grade Gliomas

Year: 2016
AGREE II score: Available
Developer organization: Alberta Health Services
This is a clinical practice guideline for adults with low-grade gliomas (LGGs). The guideline examines the diagnosis, prognosis, and treatment of these patients. Treatment modalities discussed include surgery, radiation therapy, and chemotherapy.

EANO Guidelines for the Diagnosis and Treatment of Meningiomas

Year: 2016
AGREE II score: Unavailable
Developer organization: European Association of Neuro-Oncology
This is a clinical practice guideline for patients with meningiomas. Recommendations are provided regarding diagnosis, including radiological methods used, collection and storage of tissue, and histological verification. Different treatment and follow-up recommendations are also discussed, based on which World Health Organization (WHO) grade the meningioma is classified as (i.e. WHO grades I-III).

Radiation Therapy for Glioblastoma: American Society of Clinical Oncology Clinical Practice Guideline Endorsement of the American Society for Radiation Oncology Guideline

Year: 2016
AGREE II score: Available
Developer organization: American Society of Clinical Oncology
This clinical practice guideline is an endorsement of the American Society for Radiation Oncology's 2016 guideline on radiation therapy (RT) for glioblastoma not originating from the brainstem. This guideline provides recommendations on whether and how RT should be applied, and examines dose-fractionation, target volume design, and the effects of concurrent and adjuvant systemic therapies. Outcomes included overall and progression-free survival, recurrence rates, toxicity, and quality of life (QOL).

Radiation Therapy for Glioblastoma: An ASTRO Evidence-Based Clinical Practice Guideline

Year: 2016
AGREE II score: Available
Developer organization: American Society for Radiation Oncology
This is a clinical practice guideline for patients with glioblastoma. The guideline examines radiation therapy as treatment for these patients, and the ways in which systemic therapies modify its effects. The guideline also reviews ideal dose-fractionation, target volume design, and reirradiation for recurrent glioblastoma. Tumour-specific and patient-specific factors are considered in the recommendations.

The Role of Emerging Therapy in the Management of Patients with Diffuse Low Grade Glioma

Year: 2015
AGREE II score: Available
Developer organization: Low Grade Glioma Guidelines Task Force
A clinical practice guideline for adult patients with newly diagnosed WHO grade 2 astrocytoma, oligo-astroctyoma, or oligodendroglioma. The guideline examines the role of immunotherapy and tumour vaccines. nutrition, and alternative therapies for treatment. Outcomes of interest include adverse outcomes and self-reported use, however evidence is limited.

The Role of Neuropathology in the Management of Patients with Diffuse Low Grade Glioma: A Systematic Review and Evidence-Based Clinical Practice Guideline

Year: 2015
AGREE II score: Available
Developer organization: American Association of Neurological Surgeons/ Congress of Neurological Surgeons
This is a clinical practice guideline for the diagnosis and management of patients with diffuse low grade glioma. More specifically, the guideline addresses a number of questions related to the diagnosis and management of patients with diffuse low grade glioma including: what are the optimal neuropathological techniques to diagnose low-grade glioma in the adult; and, in adult patients with histologically-proven WHO grade II diffuse glioma, is MGMT promoter methylation testing warranted? If so, is there a preferred method? In addition to providing recommendations in response to questions like those stated above, the guideline also identifies key issues for future investigation such as the identification of distinct molecular characteristics.

The Role of Initial Chemotherapy for the Treatment of Adults with Diffuse Low Grade Glioma

Year: 2015
AGREE II score: Available
Developer organization: Low Grade Glioma Guidelines Task Force
A clinical practice guideline for adult patients with newly diagnosed low grade gliomas. The guideline examines the role of chemotherapy as adjuvant therapy of choice in treatment, tumour markets to predict benefit, optimal treatment timing and chemotherapy agents, and additional adjuvant therapies. Outcomes of interest include overall survival and progression free survival.

The Role of Radiotherapy in the Management of Patients with Diffuse Low Grade Glioma: A Systematic Review and Evidence-Based Clinical Practice Guideline

Year: 2015
AGREE II score: Available
Developer organization: American Association of Neurological Surgeons/ Congress of Neurological Surgeons
This is a clinical practice guideline for adults with newly diagnosed diffuse low grade glioma (LGG). Recommendations are drawn from the following three questions: what is the optimal role of external beam radiotherapy in the management of adult patients with newly diagnosed low-grade glioma (LGG) in terms of improving outcome (i.e. survival, complications, seizure control or other reported outcomes of interest); which radiation strategies (dose, timing, fractionation, stereotactic radiation, brachytherapy, chemotherapy) improve outcomes compared to standard external beam radiation therapy in the initial management of low grade gliomas in adults; and Do specific factors (e.g. age, volume, extent of resection, genetic subtype) identify subgroups with better outcomes following radiation therapy than the general population of adults with newly diagnosed low-grade gliomas. In addition to providing recommendations in response to these questions, the guideline also provides a discussion about key issues for future investigation. These issues include the development of novel molecular or genetic markers in low-grade gliomas, and utilizing imaging alternatives to standard MRI to assess tumor response.

The Role of Surgery in the Management of Patients with Diffuse Low Grade Glioma: A Systematic Review and Evidence-Based Clinical Practice Guideline

Year: 2015
AGREE II score: Available
Developer organization: American Association of Neurological Surgeons/ Congress of Neurological Surgeons
This is a clinical practice guideline for patients with diffuse low grade glioma (LGG). More specifically, these guideline recommendations apply to adults with imaging suggestive of a WHO grade 2 glioma (oligodendroglioma, astrocytoma, or oligo-astrocytoma). The central issue addressed in this guideline pertains to whether patients with imaging suggestive of LGG should undergo observation versus treatment involving a surgical procedure.

The Role of Biopsy in the Management of Patients with Presumed Diffuse Low Grade Glioma: A Systematic Review and Evidence-Based Clinical Practice Guideline

Year: 2015
AGREE II score: Available
Developer organization: American Association of Neurological Surgeons/ Congress of Neurological Surgeons
This clinical practice guideline is for adult patients with imaging suggestive of low-grade glioma. The guideline discusses the optimal role of biopsy in the initial management of presumptive low-grade glioma, and provides recommendations on the best technique for biopsy. Primary outcomes of interest include diagnostic accuracy, morbidity and mortality. Advanced imaging for tumor targeting is also discussed.

Tobacco Screening And Treatment For Adult Cancer Patients

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adults (aged 18 and older) at any phase of the cancer care continuum regardless of cancer type, stage (including metastatic) or treatment plan, with some components of the guideline also applicable to the patient's family and/or caregivers. The guideline provides recommendations on implementation of the brief tobacco intervention, using the evidence-based 5 A’s model (ASK, ADVISE, ASSESS, ASSIST, ARRANGE) which includes screening, education and assessment, treatment plan, and referral, monitoring, and follow-up. Clinical considerations and contraindications of treatment options for cancer patients are discussed including nicotine replace therapy (NRT), bupropion, varenicline, and e-cigarettes. The impact of tobacco use on cancer treatment is also reviewed with a specific focus on erlotinib and irinotecan.

Oncogenetic Testing and Follow-up for Women With Familial Breast/Ovarian Cancer, Li-Fraumeni Syndrome and Cowden Syndrome

Year: 2015
AGREE II score: Available
Developer organization: Belgian Health Care Knowledge Centre
This is a clinical practice guideline for adult women (18 years and older) either without breast cancer or with a recent diagnosis of breast cancer, who have a family history of breast, ovarian or a related cancer; the guideline also provides recommendations for men affected by male breast cancer. The guideline discusses oncogenetic testing aspects of breast cancer and ovarian, specifically hereditary breast cancer, the Li-Fraumeni syndrome, and the Cowden syndrome. Topics include criteria and indications for genetic testing, tests for which genes have clinical utility, and appropriate follow-up depending on results and family history.

Suspected Cancer: Recognition and Referral

Year: 2015
AGREE II score: Available
Developer organization: National Institute for Health and Care Excellence
This is a clinical practice guideline for patients of all age groups suspected of having cancers including lung and pleural, upper gastro-intestinal, lower gastrointestinal, breast, gynecological, urological, skin, head and neck, brain and central nervous system, haematological, sarcomas, and childhood cancers. Recommendations are provided on recognition and referral or investigations of cancer in primary care. Outcomes of interest include quality of life, sensitivity and specificity of diagnostic tests and signs/symptoms, positive and negative predictive values of diagnostic tests and signs/symptoms, and cost effectiveness.

The Role of Imaging in the Management of Adults with Diffuse Low Grade Glioma: A Systematic Review and Evidence-Based Clinical Practice Guideline

Year: 2015
AGREE II score: Available
Developer organization: American Association of Neurological Surgeons/ Congress of Neurological Surgeons
This is a clinical practice guideline for adults with a newly diagnosed lesion with a suspected or histopathologically proven low grade glioma (LGG). The objectives of the guideline are to provide recommendations on the role of imaging for management of LGG including optimal imaging techniques for both diagnsosis and follow-up, as well as imaging sequence and parameters. Techniques discussed include anatomic MR imaging, perfusion weighted MR imaging, diffusion weighted MR imaging, MR spectroscopy, PET and SPECT imaging. Primary outcome of interest is diagnostic specificity, as well as sensitivity and predicitve data.