This is a clinical practice guideline for women with newly diagnosed stage I, II, and III breast cancer who have no symptoms of distant metastasis. The guideline examines the use of imaging tests to detect distant metastases in these patients. Anatomic imaging modalities (e.g. chest x-ray, liver ultrasound, chest-abdomen-pelvis CT scan) and metabolic imaging modalities (e.g. PET/CT, PET/MR, bone scintigraphy) are specifically discussed.