HER2-Targeted Treatment for Older Patients With Breast Cancer: An Expert Position Paper from the International Society of Geriatric Oncology

This is a clinical practice guideline for older patients (i.e., over 70 years of age) with HER2-positive breast cancer. The primary objective of the guideline is to reduce the risk of cardiac events resulting from treatment-related cardiotoxicity, while still effectively reducing cancer-related morbidity and mortality. The guideline examines various anti-HER2 agents, and discusses their use in both adjuvant and neoadjuvant regimens.