This is a clinical practice guideline for patients undergoing esophagectomy for benign or malignant disease, including esophageal cancer. The guideline provides recommendations on various components of surgical management, broadly categorized as procedure-specific (e.g. preoperative nutrition, prehabilitation programs, etc.), operative (e.g. minimally invasive versus open access, timing of surgery following neoadjuvant therapy, etc.), and technical (e.g. preoperative counseling, smoking cessation, etc.). The primary outcomes of interest are perioperative morbidity and mortality.