The Duration of Anthracycline Infusion Should be at Least One Hour in Children With Cancer: A Clinical Practice Guideline

This is a clinical practice guideline for children with solid or hematological malignancies. The guideline provides recommendations for the use of anthracycline chemotherapy in these patients, while specifically focusing on the timing of therapy (i.e. prolonged infusion
duration versus shorter infusion duration). The primary outcomes of interest being compared between regimens are tumour response, quality of life, progression-free survival, overall survival, cardiotoxicity (i.e. clinical and subclinical heart failure, etc.) and adverse effects other than cardiac manifestations.