SEOM Clinical Guidelines for Anaplastic Gliomas (2017)

This is a clinical practice guideline for the diagnosis, treatment and follow-up of adult patients with anaplastic gliomas. The guideline provides a diagnostic algorithm for anaplastic gliomas that considers isocitrate dehydrogenase 1/2 (IDH1/IDH2) missense mutations and 1p/19q co-deletions. Topics of discussion include radiology, histology and molecular biology, prognostic factors, surgery, radiotherapy, options for first-line systemic treatment, support treatment (e.g., corticoids and anticonvulsants), and follow-up.