Initial Diagnostic Workup of Acute Leukemia: Guideline from the College of American Pathologists and the American Society of Hematology

This is a clinical practice guideline for adults and children with acute leukemia (AL). The guideline examines laboratory testing for the initial workup of these patients, proper diagnosis, determination of prognostic factors, and possible future monitoring of ALs including acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), and acute leukemias of ambiguous lineage. Specific topics addressed include the clinical and laboratory information that should be available during the initial evaluation, the appropriate specimens and sample types used, the types of tests that should be performed for all patients as well as for subsets of patients, the location of laboratory testing, and how test results and diagnosis should be correlated and reported.