The Role of Biopsy in the Management of Patients with Presumed Diffuse Low Grade Glioma: A Systematic Review and Evidence-Based Clinical Practice Guideline

This clinical practice guideline is for adult patients with imaging suggestive of low-grade glioma. The guideline discusses the optimal role of biopsy in the initial management of presumptive low-grade glioma, and provides recommendations on the best technique for biopsy. Primary outcomes of interest include diagnostic accuracy, morbidity and mortality. Advanced imaging for tumor targeting is also discussed.