Systemic Therapy for Recurrent, Metastatic, or Persistent Cervical Cancer

This clinical practice guideline provides recommendations on use of systemic therapy for women with metastatic, recurrent, or persistent cervical cancer including women with squamous cell carcinoma, adenosquamous carcinoma, or adenocarcinoma of the cervix. The guideline discusses use of cisplatin-paclitaxel, cisplatin-vinorelbine, cisplatin gemcitabine, and cisplatin-topotecan, and reviews the substitution of carboplatin for cisplatin in any of these combinations. Additionally, the indications for use of bevacizumab in combination with cisplatin-paclitaxel or carboplatin-paclitaxel are discussed. Primary outcomes of interest are overall survival and quality of life, with other outcomes of consideration including response rate, progression-free survival rate, and adverse effects