Consensus Recommendations for the Diagnosis and Management of Hemophagocytic Lymphohistiocytosis Associated With Malignancies

This is a clinical practice guideline on the hyperinflammatory syndrome hemophagocytic lymphohistiocytosis (HLH). As the developers state, HLH can occur in the context of malignancies and malignancy-triggered HLH should be regarded separately from HLH during chemotherapeutic treatment, which is frequently associated with an infectious trigger. Because the overlap between the features of HLH and the features of neoplasms makes it difficult to identify HLH when it occurs in malignant conditions, the guideline developers focus their recommendations on the recognition and diagnostic workup, as well as the treatment of malignancy-associated HLH.