Recommendations for the Use of WBC Growth Factors: American Society of Clinical Oncology Clinical Practice Guideline Update

This clinical practice guideline provides recommendations on the use of colony-stimulating factors (CSFs) in adults or children with a solid tumour or lymphoma who are being treated with chemotherapy. The guideline reviews indications for use of CSFs as primary or secondary prophylaxis, as well as initiation, duration, dosing, and administration. Other topics covered include the use of CSFs to increase chemotherapy dose density, and the role of CSFs as: adjuncts to progenitor-cell transplantation; in the setting of acute leukemia or myelodysplastic syndromes; and in the treatment of radiation injury. Outcomes of interest include neutropenia- and infection-related outcomes, survival (progression-free and overall survival), and outcomes related to stem-cell mobilization or transplantation.