Management of Locally Advanced and Metastatic Prostate Cancer

This is a clinical practice guideline for males with locally advanced or metastatic prostate cancer. The guideline provides recommendations on management including psychosocial care, treatment for locally advanced disease, biochemical relapse, overt metastatic disease and/or loco-regional progressive disease, and castration-resistant prostate cancer. Palliative care, complementary and alternative therapies, socio-economic aspects of advanced prostate cancer, and emerging therapies are also discussed. Outcomes of interest include treatment efficacy, toxicity, morbidity, adverse effects from surgery, survival (overall, disease-free, prostate-cancer-specific) and disease progression.