Management of Recurrent High-Grade Gliomas

This is a clinical practice guideline for adults over the age of 18 years with recurrent high-grade gliomas, including grade III anaplastic astrocytomas, anaplastic oligodendrogliomas, anaplastic oligoastrocytomas and grade IV glioblastomas. The guideline discusses diagnostic assessment for recurrence, and treatment options including systemic therapy, surgery, and re-irradiation. Factors of consideration when determining treatment course are also discussed.