Recommendations for the Management of Central Nervous System (CNS) Metastases in Women with Secondary Breast Cancer

This clinical practice guideline provides recommendations on the management of metastases in the central nervous system (CNS) in women with secondary breast cancer. Surgery, radiotherapy, systemic therapies, and multimodal treatment are reviewed. Diagnosis and management of spinal chord compression is also discussed. Outcomes of interest include survival, local control, progression free survival, recurrence of brain metastases, response rate, neurocognitive and psychological impairments, adverse events, and quality of life.