Colorectal Cancer Screening Clinical Practice Guideline

This is a clinical practice guideline for adults with average or high risk for colorectal cancer. The guideline discusses risk factors for colorectal cancer, effectiveness of screening tests, and screening strategies based on age and risk. The following screening techniques are compared: high-sensitivity guaiac fecal occult blood test (gFOBT), immunochemical fecal occult blood test (iFOBT/FIT), flexible sigmoidoscopy, colonoscopy, standard guaiac FOBT (gFOBT), air contrast barium enema, CT colonography, and fecal DNA testing. Outcomes of interest include colon cancer incidence, morbidity, and mortality, as well as outcomes of screening intervention including test effectiveness and adverse effects.